The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

Neurobiology of Aging

Volumn 12, Issue 4, 1991, Pages 295-312

  Price, J L ^a   Davis, P B ^a   Morris, J C ^a   White, D L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Alz 50; Alzheimer's disease; Amyloid; Anterior olfactory nucleus; Hippocampal field CA1; Neurofibrillary tangles; Paired helical filaments; Parahippocampal gyrus; Senile plaques

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; NEUROFIBRILLARY TANGLE; OLFACTORY NUCLEUS; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID; BIOLOGICAL MARKERS; BRAIN MAPPING; FEMALE; HIPPOCAMPUS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGE; NEUROFIBRILLARY TANGLES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025770134     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(91)90006-6     Document Type: Article

References (59)

1. Hippocampal formation
2. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with aging and dementia
3. A new definition of Alzheimer's disease: a hippocampal dementia
4. Clinical dementia rating (CDR)
5. Mild senile dementia of Alzheimer type: Research diagnostic criteria, recruitment, and description of a study population
6. Mild senile dementia of the Alzheimer type 3 Longitudinal and cross-sectional assessment
7. Evidence for etiologic heterogeneity in Alzheimer's disease
8. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
9. On areas of transition between entorhinal allocortex and temporal isocortex in the human brain—normal morphology and lamina-specific pathology in Alzheimer's disease
10. Distribution of cerebral degeneration in Alzheimer's disease
11. Limbic lobe involvement in presenile dementia
12. The limbic system in Alzheimer's disease
13. Reliability of the Washington University Clinical Dementia Rating
14. Clinicopathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
15. A4 amyloid protein deposition and the diagnosis of Alzheimer's disease
16. Retrospective postmortem dementia assessment: Validation of a new clinical interview to assist neuropathologic study
17. Olfactory dysfunction in Alzheimer's disease
18. The olfactory bulbs in Alzheimer's disease
19. Amygdaloid changes in aging and dementia
20. Alzheimer's fibrillary changes
21. Poliomyelitis in the chimpanzee
22. A new clinical scale for the staging of dementia
23. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
24. Perforant pathway changes and the memory impairment of Alzheimer's disease
25. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins
26. The entorhinal cortex of the monkey: II. Cortical afferents
27. A Clinical, pathological and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
28. Senile dementia: A focal disease in the temporal lobe
29. Neuroanatomical and neuropathological changes in normal aging and in dementia
30. Olfactory detection and identification performance are dissociated in early Alzheimer's disease
31. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
32. The topography of plaques and tangles in Down's syndrome patients of different ages
33. Mode of entry of a neurotropic arbovirus into the central nervous system
34. Validation of clinical diagnostic criteria for Alzheimer's disease
35. Very mild Alzheimer's disease: Informant-based clinical, psychometric, and pathological distinction from normal aging
36. Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain
37. Olfactory thresholds are associated with degree of dementia in Alzheimer's disease
38. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease
39. Olfactory system
40. The limbic region. II: The amygdaloid complex
41. The nucleus basalis shows little cell loss or other pathological change in mild Alzheimer's disease
42. Basal forebrain cholinergic neurons and neuritic plaques in primate brain
43. Olfactory deficits as a neurological sign in dementia of the Alzheimer type
44. Alzhemer's disease may begin in the nose and may be caused by aluminosilicates
45. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease
46. A conservative viewpoint on linkage in Alzheimer's disease
47. Very mild senile dementia of the Alzheimer type. I. Clinical assessment
48. Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: Possible role in cell loss
49. Isolation of low-molecular weight proteins from amyloid plaque fibers in Alzheimer's disease
50. Familial Alzheimer's disease: Progress and problems
51. The limbic region. I: The septohippocampal system
52. Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles
53. Observations on the brains of nondemented old people
54. Observations on the brains of demented old people
55. Alzheimer changes in nondemented patients younger than sixty-five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type
56. The variable topography of Alzheimer type changes in senile dementia and normal old age
57. Ocurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
58. Alzheimer-related neuronal protein A68: specificity and distribution