The regulation by iron of the synthesis of adhesins and cytoadherence levels in the protozoan Trichomonas vaginalis

Journal of Experimental Medicine

Volumn 174, Issue 2, 1991, Pages 311-318

  Lehker, Michael W ^a   Arroyo, Rossana ^a   Alderete, John F ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; IRON; LACTOFERRIN;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TRICHOMONAS VAGINALIS;

AMANITINS; ANIMAL; CELL ADHESION; CYCLOHEXIMIDE; DACTINOMYCIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HELA CELLS; HUMAN; IMMUNOBLOTTING; IRON; MICROBIOLOGICAL TECHNIQUES; PROTOZOAN PROTEINS; RABBITS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSLATION, GENETIC; TRICHOMONAS VAGINALIS;

EID: 0025766755     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.174.2.311     Document Type: Article

References (31)

1. Abraham, S.N., and E.H. Beachey. 1985. Host defenses against adhesion of bacteria to mucosal surfaces. In Advances in Host Defense Mechanisms, Volume 4, Mucosal Immunity. J.I. Gallin and A.S. Fauci, editor. Raven Press, New York. 63-88.
2. Alderete, J.F., P. Demeš, A. Gombošova, M. Valent, M. Fabošova, A. janoška, J. Štefanović, and R. Arroyo. 1988. Specific parasitism of purified vaginal epithelial cells by Trichomonas vaginalis. Infect. Immun. 56:2558.
3. Alderete, J.F., and G.E. Garza. 1988. Identification and properties of Trichomonas vaginalis proteins involved in cytadherence. Infect. Immun. 56:28.
4. Arroyo, R., andJ.F. Alderete. 1989. Trichomonas vaginalis proteinase activity is necessary for parasite cytadherence. Infect. Immun. 57:2991.
5. Lehker, M.W., and J.F. Alderete. 1990. Properties of Trichomonas vaginalis grown under chemostat growth conditions. Genitourin. Med. 66:193.
6. Gorrell, T.E. 1985. Effect of culture medium iron content on the biochemical composition and metabolism of Trichomonas vaginalis. J. Bacteriol. 161:1228.
7. Lehker, M.W., and J.F. Alderete. 1991. Iron regulates several Trichomonas vaginalis virulence properties and expression of protein immunogens. J. Mol. Microbiol. In press.
8. Alderete, J.F. 1983. Antigen analysis of several pathogenic strains of Trichomonas vaginalis. Infect. Immun. 39:1041.
9. Neale, K.A., and J.F. Alderete. 1990. Analysis of the proteinases of representative Trichomonas vaginalis isolates. Infect. Immun. 58:157.
10. Peterson, K.M., and J.F. Alderete. 1982. Host plasma proteins on the surface of pathogenic Trichomonas vaginalis. Infect. Immun. 37:755.
11. Alderete, J.F. 1983. Identification of immunogenic and antibody-binding membrane proteins of pathogenic Trichomonas vaginalis. Infect. Immun. 40:284.
12. Lockwood, B.C., M.J. North, and G.H. Coombs. 1987. The release of hydrolases from Trichomonas vaginalis and Tritricho-monas foetus. Mol. Biochem. Parasitol. 30:135.
13. Neale, K.A., and J.F. Alderete. 1989. Relatedness of structure of a major immunogen in Trichomonas vaginalis isolates. Infect. Immun. 57:1849.
14. Alderete, J.F., and G.E. Garza. 1985. Specific nature of Trichomonas vaginalis parasitism of host cell surfaces. Infect. Immun. 50:701.
15. 4. Nature (Land.). 227:680.
16. Peterson, K.M., and J.F. Alderete. 1984. Iron uptake and increased intracellular enzyme activity follow lactoferrin binding by Trichomonas vaginalis receptors. J. Exp Med. 160:398.
17. Mazurier, J., and G. Spik. 1980. Comparative study of the iron-binding properties of human transferrins. I. Complete and sequential iron saturation and desaturation of lactoferrin. Bio-chim. Biophys. Acta. 629:399.
18. Tobwin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins. Proc Natl. Acad. Sci. USA. 76:4350.
19. Alderete, J.F., L. Suprun-Brown, L. Kasmala, J. Smith, and M. Spence. 1985. Heterogeneity of Trichomonas vaginalis and discrimination among isolates and subpopulations with sera of patients and experimentally infected mice. Infect. Immun. 49:463.
20. Lee, C.A., and S. Falkow. 1990. The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc Natl. Acad. Sci. USA. 87:4304.
21. Kennedy, M.J., A.L. Rogers, and R.J. Yancey. 1989. Environmental alteration and phenotypic regulation of Candida albicans adhesion to plastic. Infect. Immun. 57:3876.
22. Williams, P.H., and G. Hinson. 1987. Temperature-dependent transcriptional regulation of expression of fimbriae in an Escherichia coli strain isolated from a child with severe enteritis. Infect. Immun. 55:1734.
23. Eisenstein, B.I., and D.C. Dodd. 1982. Pseudocatabolite repression of type 1 fimbriae of Escherichia coli. J. Bacteriol. 151:1560.
24. Avots-Avotins, A.E., R.C. Fader, and CP. Davis. 1981. Environmental alteration and two distinct mechanisms of E. coli adherence to bladder epithelial cells. Invest. Urol. 18:364.
25. Hennecke, H. 1990. Regulation of bacterial gene expression by metal-protein complexes. Mol. Microbiol. 4:1621.
26. Miller, J.F., J.J. Mekalanos, and S. Falkow. 1989. Coordinate regulation and sensory transduction in the control of bacterial virulence. Science (Wash. DC). 243:916.
27. Theil, E.C. 1990. Regulation of ferritin and transferrin receptor mRNAs. J. Biol. Chem. 25:4771.
28. Worwood, M. 1989. An overview of iron metabolism at a molecular level. J. Intern. Med. 226:381.
29. Cohen, M.S., B.E. Britigan, M. French, and K. Bean. 1987. Preliminary observations on lactoferrin secretion in human vaginal mucus: Variation during the menstrual cycle, evidence of hormonal regulation and implications for infection with Neisseria gonorrhoea. Am. J. Obstet. Gynecol. 157:1122.
30. Lehker, M.W., T.H. Chang, D.C. Dailey, and J.F. Alderete. 1990. Specific erythrocyte binding is an additional nutrient acquisition system for Trichomonas vaginalis. J. Exp Med. 171:2165.
31. Lopez, Colombo de Allende, I.1950. Cytology of the human vagina. I. L.C. de Allende and O. Orias, editors. Hoeber, New York. 42-67.