Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon

Neuroscience Letters

Volumn 126, Issue 2, 1991, Pages 134-136

  Renzi, Daniela ^a,c   Mantellini, Paola ^a   Maggi, Carlo Alberto ^a,c   Fucini, Claudio ^b,c   Surrenti, Calogero ^b,c  

^a Gastroenterology Unit   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c Menarini Ricerche SpA   (Italy)

Author keywords

Capsaicin; Human colon; Ruthenium red; VIP

Indexed keywords

CAPSAICIN; RUTHENIUM RED; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL;

AGED; CAPSAICIN; COLON; HUMAN; IMMUNOLOGIC TECHNIQUES; MIDDLE AGE; RUTHENIUM RED; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0025764983     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(91)90537-4     Document Type: Article

References (17)

1. The effects of ruthenium red on the response of guinea-pig ileum to capsaicin
2. Peptide immunocytochemistry in afferent neurons from lower gut in rats
3. Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro
4. Effect of capsaicin pretreatment on regulatory peptides in the rat gastrointestinal tract
5. Tissue localization and relative distribution of regulatory peptides in separated layers from the human bowel
6. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, CGRP and other neuropeptides
7. The sensory-efferent function of capsaicin-sensitive neurons
8. Protective action of ruthenium red toward capsaicin desensitization of sensory fibers
9. Specific motor effects of capsaicin on human jejunum
10. The ‘efferent’ function of capsaicin-sensitive nerves, ruthenium red discriminates between different mechanisms of activation
11. Release of VIP but not CGRP-like immunoreactivity by capsaicin from the human isolated small intestine
12. Capsaicin-sensitive nerves in the gastrointestinal tract
13. Direct evidence for the involvement of vasoactive intestinal polypeptide in the motor response of the human isolated ileum to capsaicin
14. Motor response of the human isolated colon to capsaicin and its relationship to release of vasoactive intestinal polypeptide
15. Role of VIP in the function of the gut
16. Use of immunoblockade to study the involvement of peptidergic afferent nerves in the intestinal vasodilatory response to capsaicin in the dog
17. Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function