Detection of hydroxyl radicals in the post-ischemic reperfused heart using salicylate as a trapping agent

Journal of Molecular and Cellular Cardiology

Volumn 23, Issue 3, 1991, Pages 365-370

  Onodera, Tomoya ^a   Ashraf, Muhammad ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Hydroxyl radical; liquid chromatography; Oxygen free radicals; post ischemic reperfusion; Radical trapping agent; Salicylic acid

Indexed keywords

HYDROXYL RADICAL; SALICYLIC ACID;

ANIMAL TISSUE; ARTICLE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROXIDES; HYDROXYBENZOIC ACIDS; HYDROXYL RADICAL; HYDROXYLATION; IN VITRO; ISCHEMIA; MALE; MYOCARDIAL REPERFUSION; OXYGEN; RATS; RATS, INBRED STRAINS; SALICYLIC ACID; SALICYLIC ACIDS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025758874     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2828(91)90072-T     Document Type: Article

References (18)

1. Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO
2. Subcellular localization of iron in hearts exposed to exogenous oxygen-derived free radicals (Abstract)
3. Direct evidence for free radical generation by electron spin resonance spectroscopy
4. Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic isolated perfused heart
5. The coincidence of myocardial reperfusion injury and hydrogen peroxide production in the isolated rat heart
6. Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate
7. The production of hydroxyl radical from hydrogen peroxide
8. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products
9. Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamicin treated rats
10. Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo
11. The catalytic decomposition of hydrogen peroxide by iron salts
12. Molecular oxygen Friend and foe
13. Superoxide-dependent formation of hydroxyl radicals: Detection of hydroxyl radicals by the hydroxylation of aromatic compounds
14. Free radicals and myocardial ischemia and reperfusion injury
15. Effects of the free radicals scavenger DMTU and mannitol on the oxygen paradox in perfused rat hearts
16. Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals
17. Direct measurement of free radical generation following reperfusion of ischemic myocardium
18. Measurement of superoxide-derived free radicals in the reperfused heart