Indazolinones, a New Series of Redox-Active 5-Lipoxygenase Inhibitors with Built-In Selectivity and Oral Activity

Journal of Medicinal Chemistry

Volumn 34, Issue 3, 1991, Pages 1028-1036

  Bruneau, P ^a   Delvare, C ^a   Edwards, M P ^b   McMillan, R M ^b  

^a Chemin de Vrilly ^*  (France)

^b AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDRO 2 (3 PYRIDYLMETHYL) 3H INDAZOL 3 ONE; 2 (3 PYRIDYLMETHYL)INDAZOLINONE; 3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; BAICALEIN; DOCEBENONE; INDAZOLE DERIVATIVE; LEUKOTRIENE B4; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; METHYLDOPA; N (3 PHENOXY 3 PHENYLALLYL)ACETOHYDROXAMIC ACID; N [3 (3 PHENOXYPHENYL)ALLYL]ACETOHYDROXAMIC ACID; NORDIHYDROGUAIARETIC ACID; PHENIDONE; PROSTAGLANDIN E2; QUERCETIN; UNCLASSIFIED DRUG; ZILEUTON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BLOOD ANALYSIS; DOG; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; METHEMOGLOBINEMIA; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMAL; ARACHIDONATE 5-LIPOXYGENASE; CHEMISTRY; DINOPROSTONE; DOGS; HUMAN; INDAZOLES; LEUKOTRIENE B4; MALE; METHEMOGLOBINEMIA; METHYLATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; RATS, INBRED STRAINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOXANE B2;

EID: 0025756940     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00107a023     Document Type: Article

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