Prediction of human mRNA donor and acceptor sites from the DNA sequence

Journal of Molecular Biology

Volumn 220, Issue 1, 1991, Pages 49-65

  Brunak, Søren ^a   Engelbrecht, Jacob ^a   Knudsen, Steen ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

computer prediction; exon selection; human genes; intron splicing; neural network

Indexed keywords

MESSENGER RNA PRECURSOR; OLIGONUCLEOTIDE;

ALGORITHM; ARTICLE; ARTIFICIAL INTELLIGENCE; BASE PAIRING; BINDING SITE; DNA SEQUENCE; DONOR SITE; EXON; PREDICTION; PRIORITY JOURNAL; RNA SPLICING;

BASE SEQUENCE; COMPARATIVE STUDY; DATABASES, FACTUAL; DNA; EXONS; HUMAN; INTRONS; MOLECULAR SEQUENCE DATA; PROBABILITY; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0025744474     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(91)90380-O     Document Type: Article

References (52)

1. Protein structure and homology by neural networks
2. A novel approach to prediction of the 3-dimensional structures of protein backbones by neural networks
3. Cleaning up gene databases
4. Neural network detects errors in the assignment of pre-mRNA splice sites
5. The 3′ splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein
6. Recognition of protein coding regions in DNA sequences
7. Inhibition of splicing but not cleavage at the 5′ splice site by truncating human B-globin pre-mRNA
8. The length of the downstream exon and the substitution of specific sequences affect pre-mRNA splicing in vitro
9. The protein identification resource (PIR)
10. Pre-mRNA splicing
11. Distribution and consensus of branch point signals in eucaryotic genes: a computerized statistical analysis
12. A survey on intron and exon lengths
13. Protein secondary structure prediction with a neural network
14. The 5′ splice site: phylogenetic evolution and variable geometry of the association with U1 RNA
15. Intron splicing: a conserved internal signal in introns of animal pre-mRNAs
16. Isolation and characterization of cDNA for chicken muscle adenylate kinase
17. Improvements in protein secondary prediction by an enhanced neural network
18. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro
19. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites
20. Syntactic pattern analysis of 5′ splice site sequences of mRNA precursors in higher eucaryote genes
21. Evidence against a scanning model for RNA splicing
22. Application of neural networks and other machine learning algorithms to DNA sequence analysis
23. Comparison of the predicted and observed secondary structure of T4 phage lysozyme
24. Human adenylate kinase deficiency associated with hemolytic anemia
25. New analytical tool for analysis of splice site sequence determinants
26. A catalogue of splice junction sequences
27. The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro
28. Prediction of splice junctions in mRNA sequences
29. Splice site selection and ribonucleoprotein complex assembly during in vitro Pre-mRNA splicing
30. Signals for the selection of a splice site in pre-mRNA
31. Training neural networks to analyse biological sequences
32. Predicting the secondary structure of globular proteins using neural network models
33. A role for exon sequences and splice-site proximity in splice site selection
34. Exon definition may facilitate splice site selection in RNAs with multiple exons
35. Parallel networks that learn to pronounce English text
36. A mathematical theory of communication
37. A mathematical theory of communication
38. RNA splice junctions of different classes of eucaryotes: sequence statistics and functional implications in gene expression
39. Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns
40. Computer methods to locate signals in nucleic acids sequences
41. Measurements of the effects that coding for a protein has on a DNA sequence and their use for finding genes
42. A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein
43. Specific transcription and RNA splicing defects in five cloned Beta-thalassemia genes
44. A minimal intron length but no specific internal sequence is required for splicing the large rabbit B-globin intron
45. A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation