Importance of the nef gene for maintenance of high virus loads and for development of AIDS

Cell

Volumn 65, Issue 4, 1991, Pages 651-662

  Kestier III, Harry W ^a   Ringler, Douglas J ^a   Mori, Kazuyasu ^a   Panicali, Dennis L ^b   Sehgal, Prabhat K ^a   Daniel, Muthiah D ^a   Desrosiers, Ronald C ^a  

^a NEW ENGLAND PRIMATE RESEARCH CENTER   (United States)

^b Applied BioMath   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LYMPH NODE; MONKEY; NEF GENE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

ANIMAL; ANTIBODY FORMATION; BASE SEQUENCE; CELL LINE; CHROMOSOME DELETION; CLONING, MOLECULAR; CODON; GENES, NEF; HUMAN; MACACA MULATTA; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIV; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; VIRUS REPLICATION;

EID: 0025743306     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90097-I     Document Type: Article

References (50)

1. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR
2. A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients
3. Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy
4. Necropsy findings in rhesus monkeys experimentally infected with cultured simian immunodeficiency virus (SIV)/Delta
5. Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys
6. Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses
7. Lymphadenopathy in macaques experimentally infected with the simian immunodeficiency virus (SIV)
8. Differential effects of nef on HIV replication: implications for viral pathogenesis in the host
9. Identification of a protein encoded by the vpu gene of HIV-1
10. Identification of HIV-1 vpr product and function
11. Functions of the auxillary gene products of the human immunodeficiency virus type 1
12. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques
13. Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus
14. Simian immunodeficiency virus from African green monkeys
15. The simian immunodeficiency viruses
16. Herpesvirus tamarinus and its relation to herpes simplex virus
17. The use of simian immunodeficiency viruses for AIDS research
18. Infectious mutants of HTLV-III with changes in the 3′ region and markedly reduced cytopathic effects
19. The sor gene of HIV-1 is required for efficient virus transmission in vitro
20. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product
21. Vpx mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes
22. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor
23. Selective extraction of polyoma DNA from infected mouse cell cultures
24. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons
25. Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product
26. Genetic characterization of human immunodeficiency virus type 1 nef gene products translated in vitro and expressed in mammalian cells
27. In vitro growth characteristics of simian T-lymphotropic virus type III
28. Comparison of simian immunodeficiency virus isolates
29. Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus
30. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1
31. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
32. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III
33. Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication
34. Functional comparison of the rev trans-activators encoded by different primate immunodeficiency virus species
35. Efficient DNA transfection and rapid assay for thymidine kinase activity and viral antigenic determinants
36. Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly cloned SIVmac
37. Human immunodeficiency virus type 1 negative factor is a transcriptional silencer
38. Mutational analysis of the human immunodeficiency virus vpr open reading frame
39. Polymorphism of the 3′ open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III
40. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus
41. Cellular localization of simian immunodeficiency virus in lymphoid tissues. I. Immunohistochemistry and electron microscopy
42. Complementation of the rev gene mutation among human and simian lentiviruses
43. DNA sequencing with chain-terminating inhibitors
44. Efficient infection of monkey cells with DNA of simian virus 40
45. The HIV “A” (sor) gene product is essential for virus infectivity
46. A novel gene of HIV-1, vpu, and its 16-kilodalton product
47. Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity
48. Simian immunodeficiency virus displays complex patterns of RNA splicing
49. Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template
50. Heterogeneity of nef proteins in cells infected with human immunodeficiency virus type 1