Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 88, Issue 17, 1991, Pages 7595-7599

  Agrawal, Sudhir ^a   Temsamani, Jamal ^b   Tang, Jin Yan ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HYBRIDON INC   (United States)

Author keywords

Antisense inhibition of gene expression; Antiviral therapy; Human immunodeficiency virus; Oligodeoxynucleotide uptake

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS;

ANTISENSE OLIGONUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR STABILITY; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL;

ANIMAL; BASE SEQUENCE; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; SULFUR RADIOISOTOPES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIONUCLEOTIDES; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0025743216     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.88.17.7595     Document Type: Article

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