Serpin tertiary structure transformation

Journal of Molecular Biology

Volumn 221, Issue 2, 1991, Pages 615-621

  Stein, Penelope ^a   Chothia, Cyrus ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

ovalbumin; serpin; structure; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; OVALBUMIN; SERINE PROTEINASE INHIBITOR;

ARTICLE; CONFORMATIONAL TRANSITION; HUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SERPINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0025742788     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(91)80076-7     Document Type: Article

References (22)

1. The protein data bank: a computer-based archival file for macromolecular structures
2. Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and a large increase in conformational stability on cleavage at their reactive sites
3. 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis
4. Principles that determine the structure of proteins
5. The relation between the divergence of sequence and structure in proteins
6. 1-proteinase inhibitor
7. Absence of large scale conformational change upon limited proteolysis of ovalbumin, the prototypic serpin
8. Properties of thrombin and elastase modified human antithrombin III
9. 1-antitrypsin for the structure and function of serpins
10. Packing of α-helices onto β-pleated sheets and the anatomy of α/β proteins
11. 1-proteinase inhibitor by Crotalus adamanteus proteinase II
12. The interpretation of protein structures: estimation of static accessibility
13. 1-proteinase inhibitor. Crystal structure analysis of 2 crystal modifications, molecular model and preliminary analysis of the implications for function
14. Hormone binding globulins undergo serpin conformational change in inflammation
15. The structural basis for neutrophil inactivation of C1-inhibitor
16. Mechanisms of cooperativity and allosteric regulation in proteins
17. 1-proteinase inhibitor by proteinases from Staphylococcus aureus
18. RIBBON a stereo cartoon drawing program for proteins
19. The interpretation of protein structures: total volume, group volume distributions and packing density
20. Ovalbumin and angiotensinogen lack serpin SR conformational change
21. Crystal structure of ovalbumin as a model for the reactive centre of serpins
22. Crystal structure of plakabulmin, a proteolytically nicked form of ovalbumin. Its relationship to the structure of cleaved α-proteinase inhibitor