Ethanol Consumption Inhibits Fetal DNA Methylation in Mice: Implications for the Fetal Alcohol Syndrome

Alcoholism: Clinical and Experimental Research

Volumn 15, Issue 3, 1991, Pages 395-398

  Garro, Anthony J ^a,c   McBeth, Dani L ^b,c   Lima, Viera ^b   Lieber, Charles S ^c,d  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

5 Methylcytosine; DNA Methylation; Fetal Alcohol Syndrome

Indexed keywords

DNA METHYLTRANSFERASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ENZYME INHIBITION; FEMALE; FETAL ALCOHOL SYNDROME; FETUS; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL;

ANIMAL; CELL DIFFERENTIATION; CYTOSINE; DNA DAMAGE; DNA MUTATIONAL ANALYSIS; FEMALE; FETAL ALCOHOL SYNDROME; GENE EXPRESSION REGULATION; MICE; PREGNANCY; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0025738978     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1991.tb00536.x     Document Type: Article

References (45)

1. Les enfants de parents alcoholiques. Anomalies observees: A propos de 127 cas
2. Recognition of the FAS in early infancy
3. A clinical perspective of the fetal alcohol syndrome
4. Intelligence, behavior and dysmorphogenesis in the fetal alcohol syndrome: A report of 20 clinical cases
5. Incidence of fetal alcohol syndrome and economic impact of FAS‐related anomalies
6. Ethanol‐induced malformations in mice
7. The fetal alcohol syndrome in mice: An animal model
8. Fetal alcohol syndrome: Embryogenesis in a mouse model
9. Determination of the proximate teratogen in the mouse fetal alcohol syndrome. 1. Teratogenicity of ethanol and acetaldehyde
10. Ethanol embryotoxicity: Direct effects on mammalian embryos
11. The effects of ethanol on rat embryos developing in vitro
12. 14C‐ethanol
13. Disposition of ethanol in human maternal blood and amniotic fluid
14. Determination of the proximal teratogen in the fetal alcohol syndrome. 2. Pharmacokinetics of the placental transfer of ethanol and acetaldehyde
15. Acetaldehyde and alcohol levels in pregnant rats and their fetuses
16. Fetal alcohol syndrome: Inhibition of placental zinc transport as a potential mechanism for fetal growth retardation in the rat
17. Ethanol and fetal nutrition: Effect of chronic ethanol exposure on rat placental growth and membrane‐associated folic acid receptor binding activity
18. Ethanol‐induced intrauterine growth retardation: Correlation with placental glucose transport
19. Effect of acetaldehyde on the neurorepithelium of early mouse embryos
20. Teratogenic effects of acetaldehyde in the rat
21. Some teratogenic properties of ethanol and acetaldehyde in C57BL/65: Implications for the study of the fetal alcohol syndrome
22. Acetaldehyde production and transfer by the perfused human placental cotyledon
23. Fetal abnormality and maternal ethanol metabolism
24. DNA methylation and gene function
25. Hypomethylation of DNA during differentiation of Friend erythroleukemic cells
26. CpG‐rich islands and the function of DNA methylation
27. The inheritance of epigenetic defects
28. DNA methylation and gene activity
29. Comparison of transformation efficiency of human active and inactive X‐chromosome DNA
30. Methylation of hypoxanthine phosphoryl transferase locus on the human X chromosome: Implication for X chromosome inactivation
31. Methylation of the Hprt gene on the inactive X chromosome occurs after chromosome inactivation
32. Specificity of HpaII and HaeIII DNA methylases
33. Rapid appearance of hypomethylated DNA in livers of rats fed cancer‐promoting, methyl‐deficient diets
34. A simple and rapid method for the isolation of enzymatically active HeLa cell nuclei
35. Protein measurement with the folin phenol reagent
36. The effect of S‐adenosylhomocysteine on DNA methylation in isolated rat liver nuclei
37. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5‐azacytidine and 5‐aza‐2′‐deoxycytidine
38. Hypomethylation of DNA during differentiation of Friend erythroleukemia cells
39. S‐adenosyl‐L‐methionine attenuates alcohol‐induced liver injury in the baboon
40. Problems and pitfalls in acetaldehyde determinations
41. Elimination of artifactual acetaldehyde in the measurement of human blood acetaldehyde by the use of polyethylene glycol and sodium azide: Normal blood acetaldehyde levels in the dog and human after ethanol
42. Inhibition of DNA methylase activity by acrolein
43. Binding of acetaldehyde to rat liver microsomes: Enhancement after chronic alcohol consumption
44. 6 methylguanine transferase