메뉴 건너뛰기




Volumn 266, Issue 1, 1991, Pages 93-98

Analysis and Interpretation of Treatment Effects in Subgroups of Patients in Randomized Clinical Trials

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; HUMAN; PRIORITY JOURNAL; RANDOMIZATION;

EID: 0025737883     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1991.03470010097038     Document Type: Article
Times cited : (791)

References (37)
  • 2
    • 0020358354 scopus 로고
    • Patient subsets and variation in therapeutic efficacy
    • Simon R. Patient subsets and variation in therapeutic efficacy. Br J Clin Pharmacol. 1982;14:473-482.
    • (1982) Br J Clin Pharmacol , vol.14 , pp. 473-482
    • Simon, R.1
  • 3
    • 0023938931 scopus 로고
    • Subgroup analysis
    • Bulpitt CJ. Subgroup analysis. Lancet. 1988;2:31-34.
    • (1988) Lancet , vol.2 , pp. 31-34
    • Bulpitt, C.J.1
  • 4
    • 0022007270 scopus 로고
    • Methodologic guidelines for reports of clinical trials
    • Simon R, Wittes R. Methodologic guidelines for reports of clinical trials. Cancer Treat Rep. 1985;69:1-3.
    • (1985) Cancer Treat Rep , vol.69 , pp. 1-3
    • Simon, R.1    Wittes, R.2
  • 5
    • 0018962999 scopus 로고
    • Influence of adherence to treatment and response of cholesterol on mortality in the Coronary Drug Project
    • The Coronary Drug Project Research Group. Influence of adherence to treatment and response of cholesterol on mortality in the Coronary Drug Project. N Engl J Med. 1980;303:1038-1041.
    • (1980) N Engl J Med , vol.303 , pp. 1038-1041
  • 6
    • 0025073486 scopus 로고
    • Selection of patients for randomized controlled trials: implications of wide or narrow eligibility criteria
    • Yusuf S, Held P, Teo KK, Toretsky ER. Selection of patients for randomized controlled trials: implications of wide or narrow eligibility criteria. Stat Med. 1990;9:73-86.
    • (1990) Stat Med , vol.9 , pp. 73-86
    • Yusuf, S.1    Held, P.2    Teo, K.K.3    Toretsky, E.R.4
  • 7
    • 0023694811 scopus 로고
    • Overview of results of randomized clinical trials in heart disease, I: treatments following myocardial infarction
    • Yusuf S, Wittes J, Friedman L. Overview of results of randomized clinical trials in heart disease, I: treatments following myocardial infarction. JAMA. 1988;260:2088-2093.
    • (1988) JAMA , vol.260 , pp. 2088-2093
    • Yusuf, S.1    Wittes, J.2    Friedman, L.3
  • 8
    • 0023747123 scopus 로고
    • Overview of results of randomized clinical trials in heart disease, II: unstable angina, heart failure, primary prevention with aspirin, and risk factor modification
    • Yusuf S, Wittes J, Friedman L. Overview of results of randomized clinical trials in heart disease, II: unstable angina, heart failure, primary prevention with aspirin, and risk factor modification. JAMA. 1988;260:2259-2263.
    • (1988) JAMA , vol.260 , pp. 2259-2263
    • Yusuf, S.1    Wittes, J.2    Friedman, L.3
  • 9
    • 0022640774 scopus 로고
    • Gruppo Italiano per lo Studio della Streptochinasi nell’Infarcto Miocardico (GISSI): Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction
    • Gruppo Italiano per lo Studio della Streptochinasi nell’Infarcto Miocardico (GISSI): Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet. 1986;1:397-401.
    • (1986) Lancet , vol.1 , pp. 397-401
  • 10
    • 0023805341 scopus 로고
    • Randomized trial of IV streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction
    • ISIS-2 Collaborative Group. Randomized trial of IV streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction. Lancet. 1988;2:349-360.
    • (1988) Lancet , vol.2 , pp. 349-360
  • 11
    • 0023783508 scopus 로고
    • Trials of tissue plasminogen activator for mortality reduction in acute myocardial infarction: Anglo-Scandinavian Study of Early Thrombolysis (ASSET)
    • Wilcox RG, von der Lippe G, Olsson CG, et al. Trials of tissue plasminogen activator for mortality reduction in acute myocardial infarction: Anglo-Scandinavian Study of Early Thrombolysis (ASSET). Lancet. 1988;2:525-530.
    • (1988) Lancet , vol.2 , pp. 525-530
    • Wilcox, R.G.1    von der Lippe, G.2    Olsson, C.G.3
  • 12
    • 0023835206 scopus 로고
    • Effect of intravenous ASPAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial
    • AIMS Trial Study Group. Effect of intravenous ASPAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial. Lancet. 1985;1:545-549.
    • (1985) Lancet , vol.1 , pp. 545-549
  • 13
    • 0024997417 scopus 로고
    • Routine medical management of acute myocardial infarction: lessons from overviews of recent randomized controlled trials
    • Yusuf S. Sleight P, Held P, MacMahon S. Routine medical management of acute myocardial infarction: lessons from overviews of recent randomized controlled trials. Circulation. 1990;82:117-134.
    • (1990) Circulation , vol.82 , pp. 117-134
    • Yusuf, S.1    Sleight, P.2    Held, P.3    MacMahon, S.4
  • 15
    • 0025256870 scopus 로고
    • Empirical Bayes estimates of subgroup effects in clinical trials
    • Davis CE, Leffingwell DP. Empirical Bayes estimates of subgroup effects in clinical trials. Controlled Clin Trials. 1990;11:37-42.
    • (1990) Controlled Clin Trials , vol.11 , pp. 37-42
    • Davis, C.E.1    Leffingwell, D.P.2
  • 16
    • 0039294558 scopus 로고
    • Discussion on papers by Wynn, Bloomfield, O’Neill, and Wetherill
    • Nelder JA. Discussion on papers by Wynn, Bloomfield, O’Neill, and Wetherill. J Royal Stat Soc Series B. 1971;33:244-246.
    • (1971) J Royal Stat Soc Series B , vol.33 , pp. 244-246
    • Nelder, J.A.1
  • 17
    • 0024263819 scopus 로고
    • Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension
    • Systolic Hypertension in the Elderly Cooperative Research Group. Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension. J Clin Epidemiol. 1989;41:1197-1208.
    • (1989) J Clin Epidemiol , vol.41 , pp. 1197-1208
  • 18
    • 0025285390 scopus 로고
    • Studies of left ventricular dysfunction (SOLVD)—rationale, design, and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction
    • The SOLVD Investigators. Studies of left ventricular dysfunction (SOLVD)—rationale, design, and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction. Am J Cardiol. 1990;66:315-322.
    • (1990) Am J Cardiol , vol.66 , pp. 315-322
  • 19
    • 0021256897 scopus 로고
    • Effect of propranolol in post infarction patients with mechanical or electrical complications
    • Furberg CD, Hawkins CM, Lichstein E. Effect of propranolol in post infarction patients with mechanical or electrical complications. Circulation. 1984;69:761-765.
    • (1984) Circulation , vol.69 , pp. 761-765
    • Furberg, C.D.1    Hawkins, C.M.2    Lichstein, E.3
  • 21
    • 0021839784 scopus 로고
    • Metoprolol in acute myocardial infarction (MIAMI): a randomized placebo-controlled international trial
    • The MIAMI Trial Research Group. Metoprolol in acute myocardial infarction (MIAMI): a randomized placebo-controlled international trial. Eur Heart J. 1985;6:199-226.
    • (1985) Eur Heart J , vol.6 , pp. 199-226
  • 22
    • 0018642563 scopus 로고
    • Effect of alprenolol on mortality among patients with definite or suspected acute myocardial infarction: preliminary results
    • Andersen MP, Bechsgaard P, Frederiksen J, et al. Effect of alprenolol on mortality among patients with definite or suspected acute myocardial infarction: preliminary results. Lancet. 1979;2:865-868.
    • (1979) Lancet , vol.2 , pp. 865-868
    • Andersen, M.P.1    Bechsgaard, P.2    Frederiksen, J.3
  • 23
    • 0021909115 scopus 로고
    • Betablockade during and after myocardial infarction: an overview of the randomized trials
    • Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Betablockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis. 1985;27:335-371.
    • (1985) Prog Cardiovasc Dis , vol.27 , pp. 335-371
    • Yusuf, S.1    Peto, R.2    Lewis, J.3    Collins, R.4    Sleight, P.5
  • 24
    • 0019520254 scopus 로고
    • Effect on mortality of metoprolol in acute myocardial infarction: a double-blind randomised trial
    • Hjalmarson A, Elmfeldt D, Herlitz J, et al. Effect on mortality of metoprolol in acute myocardial infarction: a double-blind randomised trial. Lancet. 1981;2:823-827.
    • (1981) Lancet , vol.2 , pp. 823-827
    • Hjalmarson, A.1    Elmfeldt, D.2    Herlitz, J.3
  • 25
    • 84888827980 scopus 로고
    • Randomised trial of intravenous atenolol among 16,027 cases of acute myocardial infarction: ISIS-1
    • ISIS-1 Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of acute myocardial infarction: ISIS-1. Lancet. 1986;2:57-66.
    • (1986) Lancet , vol.2 , pp. 57-66
  • 26
    • 0016275043 scopus 로고
    • Reduction of sudden deaths after myocardial infarction by treatment with alprenolol
    • Wilhelmsson C, Vedin JA, Wilhelmsen I, et al. Reduction of sudden deaths after myocardial infarction by treatment with alprenolol. Lancet. 1974;92:1157-1160.
    • (1974) Lancet , vol.92 , pp. 1157-1160
    • Wilhelmsson, C.1    Vedin, J.A.2    Wilhelmsen, I.3
  • 27
    • 0021038370 scopus 로고
    • A randomized trial of propranolol in patients with acute myocardial infarction, II: morbidity results
    • Beta-blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction, II: morbidity results. JAMA. 1983;250:2814-2819.
    • (1983) JAMA , vol.250 , pp. 2814-2819
  • 28
    • 0023900164 scopus 로고
    • The Beta-Blocker Pooling Project (BBPP): subgroup findings from randomized trials in post infarction patients
    • The Beta-Blocker Pooling Research Group. The Beta-Blocker Pooling Project (BBPP): subgroup findings from randomized trials in post infarction patients. Eur Heart J. 1988;9:8-16.
    • (1988) Eur Heart J , vol.9 , pp. 8-16
  • 29
    • 0017735987 scopus 로고
    • Supplementary report: reduction in mortality after myocardial infarction with long-term beta-adrenoreceptor blockade
    • Multicenter International Study. Supplementary report: reduction in mortality after myocardial infarction with long-term beta-adrenoreceptor blockade. BMJ. 1977;2:419-421.
    • (1977) BMJ , vol.2 , pp. 419-421
  • 30
    • 0019919373 scopus 로고
    • A long-term prevention study with oxprenolol in coronary heart disease
    • Taylor SH, Silke B, Ebutt A, et al. A long-term prevention study with oxprenolol in coronary heart disease. N Engl J Med. 1982;307:1293-1301.
    • (1982) N Engl J Med , vol.307 , pp. 1293-1301
    • Taylor, S.H.1    Silke, B.2    Ebutt, A.3
  • 31
    • 84953030627 scopus 로고
    • Stochastically curtailed tests in long-term clinical trials
    • Lan KKG, Simon R, Halperin M. Stochastically curtailed tests in long-term clinical trials. Communications Stat. 1982;35:207-219.
    • (1982) Communications Stat , vol.35 , pp. 207-219
    • Lan, K.K.G.1    Simon, R.2    Halperin, M.3
  • 32
    • 70449529019 scopus 로고
    • Discrete sequential boundaries for clinical trials
    • Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika. 1983;70:659-663.
    • (1983) Biometrika , vol.70 , pp. 659-663
    • Lan, K.K.G.1    DeMets, D.L.2
  • 33
    • 84944965306 scopus 로고
    • Findings leading to further modifications of its protocol with respect to dextrothyroxine
    • The Coronary Drug Project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. JAMA. 1972;219:990-1008.
    • (1972) JAMA , vol.219 , pp. 990-1008
  • 34
    • 0021791076 scopus 로고
    • Estimating baseline values of the variable of intervention in a clinical trial
    • Knoke JD, Hawkins DL. Estimating baseline values of the variable of intervention in a clinical trial. Cont Clin Trials. 1985;6:136-145.
    • (1985) Cont Clin Trials , vol.6 , pp. 136-145
    • Knoke, J.D.1    Hawkins, D.L.2
  • 35
    • 0024502084 scopus 로고
    • Surrogate endpoints in clinical trials: cardiovascular disease
    • Wittes J, Lakatos E, Probstfield J. Surrogate endpoints in clinical trials: cardiovascular disease. Stat Med. 1989;8:415-425.
    • (1989) Stat Med , vol.8 , pp. 415-425
    • Wittes, J.1    Lakatos, E.2    Probstfield, J.3
  • 36
    • 0023218424 scopus 로고
    • Avoidance of large biases and large random errors in the assessment of moderate treatment effects: the need for systematic overviews
    • Collins R, Gray R, Godwin J, Peto R. Avoidance of large biases and large random errors in the assessment of moderate treatment effects: the need for systematic overviews. Stat Med. 1987;6:245-250.
    • (1987) Stat Med , vol.6 , pp. 245-250
    • Collins, R.1    Gray, R.2    Godwin, J.3    Peto, R.4
  • 37
    • 0024269590 scopus 로고
    • Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer
    • Early Breast Cancer Trialists’ Collaborative Group. Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. N Engl J Med. 1988;319:1681-1692.
    • (1988) N Engl J Med , vol.319 , pp. 1681-1692


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.