Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex

Neuroscience Letters

Volumn 128, Issue 2, 1991, Pages 199-202

  Nitsch, Roger ^a   Hoyer, Siegfried ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Animal model; ATP; Brain cortex; Brain energy metabolism; Glucose; Streptozotocin

Indexed keywords

ADENOSINE TRIPHOSPHATE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; ENERGY METABOLISM; GLUCOSE METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMAL; CEREBRAL CORTEX; CITRIC ACID CYCLE; ENERGY METABOLISM; GLUCOSE; GLYCOLYSIS; INJECTIONS, INTRAVENTRICULAR; LACTATES; MALE; PHOSPHOCREATINE; RATS; RATS, INBRED STRAINS; STREPTOZOCIN; SUPPORT, NON-U.S. GOV'T;

EID: 0025737376     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(91)90260-Z     Document Type: Article

References (28)

1. The energy charge of the adenylate pool as a regulatory parameter
2. Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion
3. Unilateral and bilateral nucleus basalis lesions: differences in neurochemical and behavioural recovery
4. Effects of changes in brain metabolism on the levels of citric acid cycle intermediates
5. Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels
6. Abnormalities in glucose and energy metabolism are more severe in the hippocampus than in cerebral cortex in postischemic recovery in aged rats
7. Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?
8. Diabetogenic action of streptozotocin: relationship of dose to metabolic response
9. Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin diabetic rats
10. Mechanism for markedly hyperresponsive insulin-stimulated glucose transport activity in adipose cells from insulin-treated streptozotocin diabetes rats
11. Low-dose streptozotocin-induced diabetes in mice
12. Cerebral energy state in insulin-induced hypoglycemia, related to blood glucose and EEG
13. Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia
14. The effects of acute carbon monoxide intoxication on the cerebral energy metabolism of the rat
15. Brain energy metabolism in streptozotocin-diabetes
16. Effects of changes in peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats
17. Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycemia
18. Regional differences in brain glucose content in graded hypoglycemia
19. Optimal freezing conditions for cerebral metabolites in rats
20. Altered protein phosphorylation in sciatic nerve from rats with streptozotocin-induced diabetes
21. 14C]glucose in vitro in human neocortex
22. Influence of severe hypoglycemia on brain extracellular calcium and potassium activities, energy, and phospholipid metabolism