Fibroblasts from ataxia telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-Strand breaks after low dose-rate γirradiation as assayed by pulsed field gel electrophoresis

International Journal of Radiation Biology

Volumn 60, Issue 5, 1991, Pages 791-802

  Blocher D ^a   Sigut, D ^b   Hannan, M A ^a  

^a Medical Physics Department   (Saudi Arabia)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; DNA STRAND BREAKAGE; GAMMA RADIATION; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; SKIN FIBROBLAST;

ATAXIA TELANGIECTASIA; CELL SURVIVAL; COBALT RADIOISOTOPES; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROPHORESIS, GEL, PULSED-FIELD; FIBROBLASTS; GAMMA RAYS; HETEROZYGOTE; HUMAN;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0025734394     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553009114552601     Document Type: Article

References (43)

1. Measurement of radiation-induced DNA double-strand breaks by pulsed-field gel electrophoresis
2. An assessment of the radiosensitivity of ataxia telangiectasia heterozygotes
3. 2 chromosomal radiosensitivity in ataxia telangiectasia lymphocytes
4. CHEF electrophoresis, a sensitive technique for the determination of DNA double-strand breaks
5. In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose
6. DNA double-strand break analysis by CHEF electrophoresis
7. 241Am α-particles or bleomycin
8. On the nature of a defect in cells from individuals with ataxia-telangiectasia
9. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts
10. The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells
11. Examination of vectors with two dominant, selectable genes for DNA repair and mutation studies in mammalian cells
12. Nuclear lystate sedimentation measurements of peripheral blood lymphocytes from radiotherapy patients
13. Chromosomal aberrations and mortality of X-irradiated mammalian cells: emphasis on repair
14. Normal repair of DNA single-strand breaks in patients with ataxia telangiectasia
15. Observations of radiation-induced chromosome fragment loss in live mammalian cells in culture and its effect on colony forming ability
16. Chronic γ-radiation sensitivity of skin fibroblasts from patients with non-Hodgkin's lymphoma (NHL)
17. Diagnostics of ataxia telangiectasia by T-lymphocyte cloning assay
18. Rapid diagnostic test for ataxia telangiectasia
19. In vitro X-ray sensitivity in ataxia telangiectasia homozygote and heterozygote skin fibro-blasts under oxic and hypoxic condition
20. Radiation response of cells from human tumor biopsies as assessed by dye exclusion technique: a possible predictive assay
21. The production and repair of double-strand DNA breaks in cells from normal and from patients with ataxia telangiectasia
22. In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer
23. Can cell kinetic parameters predict the response of tumours to radiotherapy?
24. Kinetics of chromatid aberrations in G2 ataxiatelangiectasia cells exposed to X-rays and AraA
25. Detection of ataxia telangiectasia heterozygous cell lines by postirradiation cumulative labeling index: measurements with coded samples
26. Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages
27. Altered DNA synthesis in irradiated and unirradiated ataxiatelangiectasia cells
28. Enhanced radiosensitivity of cultured fibroblasts from ataxia telangiectasia heterozygotes manifested by defective colony-forming ability and reduced DNA repair after hypoxic γ-irradiation
29. Cellular hypersensitivity to chronic γ-radiation in cultured fibroblasts from ataxiatelangiectasia heterozygotes
30. The relationship between colony-forming ability and chromosomal aberrations induced in human T-lymphocytes after γ-irradiation
31. Cytogenetic status of ataxia telangiectasia
32. Screening for ataxia telangiectasia
33. Prediction of the radiation sensitivity of human squamous cell carcinoma cells using DNA filter elution
34. The response of ataxia-telangiectasia homozygous and heterozygous skin fibroblasts to neurocarcinostatin
35. Carrier detection in ataxia-telangiectasia
36. Do in vitro studies of potentially lethal damage repair predict for in situ results?
37. Asymmetric field inversion gel electrophoresis: a new method for detecting DNA double-strand breaks in mammalian cells
38. Breast and other cancers in families with ataxia-telangiectasia
39. Increased radiosensitivity and the basic defect in ataxia telangiectasia
40. Ataxia-telangiectasia: a human mutation with abnormal radiation sensitivity
41. Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations
42. Quantitative measurement of DNA strand breaks and repair in γ-irradiated human leukocytes from normal and ataxia telangiectasia donors
43. Evaluation of surviving fraction at 2 Gy as a potential prognostic factor for the radiotherapy of carcinoma of the cervix