-
2
-
-
0023184166
-
H families in adult C57BL/6 and BALB/c mice
-
H families in adult C57BL/6 and BALB/c mice. J. Exp. Med. 166:163.
-
(1987)
J. Exp. Med.
, vol.166
, pp. 163
-
-
Schulze, D.H.1
Kelsoe, G.2
-
4
-
-
0024546851
-
Mapping of antibody specificities to V., gene families
-
Kelsoe, G., R. Miceli, J. Cerny, and D.H. Schulze. 1989. Mapping of antibody specificities to V., gene families. Immunogenetics. 29:288.
-
(1989)
Immunogenetics
, vol.29
, pp. 288
-
-
Kelsoe, G.1
Miceli, R.2
Cerny, J.3
Schulze, D.H.4
-
7
-
-
0024429383
-
Comparison of Vκ gene family expression in adult and fetal B cells
-
Teale, J.M., and Morris, E.G. 1989. Comparison of Vκ gene family expression in adult and fetal B cells. J. Immunol. 143:2768.
-
(1989)
J. Immunol.
, vol.143
, pp. 2768
-
-
Teale, J.M.1
Morris, E.G.2
-
8
-
-
0024724288
-
Early rearrangements of genes encoding murine immunoglobulin κ chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus
-
Lawler, A.M., J.F. Kearney, M. Kuehl, and P. Gearhart. 1989. Early rearrangements of genes encoding murine immunoglobulin κ chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus. Proc. Natl. Acad. Sci. USA. 86:6744.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 6744
-
-
Lawler, A.M.1
Kearney, J.F.2
Kuehl, M.3
Gearhart, P.4
-
10
-
-
84910539350
-
Somatic generation of antibody diversity
-
Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature (Lond.). 286:676.
-
(1983)
Nature (Lond.)
, vol.286
, pp. 676
-
-
Tonegawa, S.1
-
11
-
-
0021216208
-
Insertion of N regions into heavy chain genes is correlated with expression of terminal deoxytransferase in B cells
-
Desiderio, S.V., G.D. Yancopoulos, M. Paskind, E. Thomas, M.A. Boss, N. Landau, F.W. Alt, and D. Baltimore. 1984. Insertion of N regions into heavy chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature (Lond.). 311:752.
-
(1984)
Nature (Lond.)
, vol.311
, pp. 752
-
-
Desiderio, S.V.1
Yancopoulos, G.D.2
Paskind, M.3
Thomas, E.4
Boss, M.A.5
Landau, N.6
Alt, F.W.7
Baltimore, D.8
-
12
-
-
0025184095
-
Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences
-
Feeney, A.M. 1990. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172:1377.
-
(1990)
J. Exp. Med.
, vol.172
, pp. 1377
-
-
Feeney, A.M.1
-
13
-
-
0025374272
-
Stochastic pairing of heavy-chain and κ light-chain variable gene families occurs in polyclonally activated B cells
-
Kaushik, A., D.H. Schulze, F.A. Bonilla, C.A. Bona, and G. Kelsoe. Stochastic pairing of heavy-chain and κ light-chain variable gene families occurs in polyclonally activated B cells. Proc. Natl. Acad. Sci. USA. 87:4932.
-
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 4932
-
-
Kaushik, A.1
Schulze, D.H.2
Bonilla, F.A.3
Bona, C.A.4
Kelsoe, G.5
-
14
-
-
12244272341
-
Is the antibody repertoire biased?
-
G. Kelsoe and D.H. Schulze, editors. University of Texas Press, Austin, TX
-
Kelsoe, G., and D. Farina. 1987. Is the antibody repertoire biased? In Evolution and Vertebrate Immunity. G. Kelsoe and D.H. Schulze, editors. University of Texas Press, Austin, TX. 163-174.
-
(1987)
Evolution and Vertebrate Immunity
, pp. 163-174
-
-
Kelsoe, G.1
Farina, D.2
-
15
-
-
84965978264
-
Specificity of the germline-encoded preimmune B cell repertoire
-
O.N. Witte, N.R. Klinman, and M.C. Howard, editors. Alan R. Liss, Inc., New York
-
White-Scharf, M.E., M. Souroujon, J. Andre-Schwartz, R.S. Schwartz, and M.L. Gefter. 1988. Specificity of the germline-encoded preimmune B cell repertoire. In B Cell Development. O.N. Witte, N.R. Klinman, and M.C. Howard, editors. Alan R. Liss, Inc., New York. 105-1187,
-
(1988)
B Cell Development
, pp. 105-1187
-
-
White-Scharf, M.E.1
Souroujon, M.2
Andre-Schwartz, J.3
Schwartz, R.S.4
Gefter, M.L.5
-
16
-
-
0025280308
-
Antigen-binding repertoire and immunoglobulin heavy chain gene usage among B cell hybridomas from normal and autoimmune mice
-
Striebich, C.C., R.M. Miceli, D.H. Schulze, G. Kelsoe, and J. Cerny. 1990. Antigen-binding repertoire and immunoglobulin heavy chain gene usage among B cell hybridomas from normal and autoimmune mice. J. Immunol. 144:1857.
-
(1990)
J. Immunol.
, vol.144
, pp. 1857
-
-
Striebich, C.C.1
Miceli, R.M.2
Schulze, D.H.3
Kelsoe, G.4
Cerny, J.5
-
17
-
-
0016671543
-
Synthesis of antibody and immunoglobulin without detectable antibody function in cells responding to horseradish peroxidase
-
Miller, H.R.P., T. Ternynck, and S. Avrameas. 1975. Synthesis of antibody and immunoglobulin without detectable antibody function in cells responding to horseradish peroxidase. J. Immunol. 114:626.
-
(1975)
J. Immunol.
, vol.114
, pp. 626
-
-
Miller, H.R.P.1
Ternynck, T.2
Avrameas, S.3
-
18
-
-
0017114239
-
Correlation between immunoglobulin- and antibody-synthesizing cells during primary and secondary immune responses of rats immunized with HRP
-
Antoine, J.C., and S. Avrameas. 1976. Correlation between immunoglobulin- and antibody-synthesizing cells during primary and secondary immune responses of rats immunized with HRP. Immunology. 30:537.
-
(1976)
Immunology
, vol.30
, pp. 537
-
-
Antoine, J.C.1
Avrameas, S.2
-
19
-
-
0020573342
-
Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response
-
Nemazee, D., and V. Saito. 1983. Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response. J. Exp. Med. 158:529.
-
(1983)
J. Exp. Med.
, vol.158
, pp. 529
-
-
Nemazee, D.1
Saito, V.2
-
20
-
-
0014572803
-
Antibody with homogenous antigen binding produced by splenic foci in organ culture
-
Klinman, N.R. 1969. Antibody with homogenous antigen binding produced by splenic foci in organ culture. Immunochemistry. 6:757.
-
(1969)
Immunochemistry
, vol.6
, pp. 757
-
-
Klinman, N.R.1
-
21
-
-
0016752326
-
Growth of B lymphocyte colonies in vitro
-
Metcalf, D., G.J.V. Nossal, N.L. Warner, J.F.A.P. Miller, T.E. Mandel, J.E. Layton, and G.A. Gutman. 1975. Growth of B lymphocyte colonies in vitro. J. Exp. Med. 142:1534.
-
(1975)
J. Exp. Med.
, vol.142
, pp. 1534
-
-
Metcalf, D.1
Nossal, G.J.V.2
Warner, N.L.3
Miller, J.F.A.P.4
Mandel, T.E.5
Layton, J.E.6
Gutman, G.A.7
-
22
-
-
0017329140
-
Clonal growth and maturation to immunoglobulin secretion in vitro of growth-inducible B lymphocyte
-
Anderson, J., A. Coutinho, W. Lernhardt, and F. Melchers. 1977. Clonal growth and maturation to immunoglobulin secretion in vitro of growth-inducible B lymphocyte. Cell. 10:27.
-
(1977)
Cell
, vol.10
, pp. 27
-
-
Anderson, J.1
Coutinho, A.2
Lernhardt, W.3
Melchers, F.4
-
23
-
-
0023473626
-
Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: Phenotypic and genotypic analysis of B cell colonies
-
Kelsoe, G. 1987. Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. Methods Enzymol. 150:287.
-
(1987)
Methods Enzymol.
, vol.150
, pp. 287
-
-
Kelsoe, G.1
-
24
-
-
0015797465
-
Strain differences in the fine specificity of mouse anti-hapten antibodies
-
Imanishi-Kari, T., and O. Makela. 1973. Strain differences in the fine specificity of mouse anti-hapten antibodies. Eur. J. Immunol. 3:323.
-
(1973)
Eur. J. Immunol.
, vol.3
, pp. 323
-
-
Imanishi-Kari, T.1
Makela, O.2
-
25
-
-
0017642791
-
Idiotypic analysis of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group
-
Jack, R.S., T. Imanishi-Kari, and K. Rajewsky. 1977. Idiotypic analysis of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group. Eur. J. Immunol. 7:559.
-
(1977)
Eur. J. Immunol.
, vol.7
, pp. 559
-
-
Jack, R.S.1
Imanishi-Kari, T.2
Rajewsky, K.3
-
26
-
-
0017623502
-
Inherited immunoglobulin idiotypes of the mouse
-
Makela, O., and K. Karjalainen. 1977. Inherited immunoglobulin idiotypes of the mouse. Immunol. Rev. 34:119.
-
(1977)
Immunol. Rev.
, vol.34
, pp. 119
-
-
Makela, O.1
Karjalainen, K.2
-
27
-
-
0018578942
-
Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotypes by monoclonal anti-idiotype antibodies
-
Reth, M., T. Imanishi-Kari, and K. Rajewsky. 1979. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotypes by monoclonal anti-idiotype antibodies. Eur. J. Immunol. 9:1004.
-
(1979)
Eur. J. Immunol.
, vol.9
, pp. 1004
-
-
Reth, M.1
Imanishi-Kari, T.2
Rajewsky, K.3
-
29
-
-
0018836189
-
Peanut lectin binding properties of germinal centres of mouse lymphoid tissue
-
Rose, M.L., M.S.C. Birbeck, V.J. Wallis, J.A. Forrester, and A.J.S. Davies. 1980. Peanut lectin binding properties of germinal centres of mouse lymphoid tissue. Nature (Lond.). 284:364.
-
(1980)
Nature (Lond.)
, vol.284
, pp. 364
-
-
Rose, M.L.1
Birbeck, M.S.C.2
Wallis, V.J.3
Forrester, J.A.4
Davies, A.J.S.5
-
30
-
-
0021855144
-
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
-
Clarke, S.H., K. Huppi, D. Ruezinsky, L. Staudt, W. Gerhard, and M. Weigert. 1985. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J. Exp. Med. 161:687.
-
(1985)
J. Exp. Med.
, vol.161
, pp. 687
-
-
Clarke, S.H.1
Huppi, K.2
Ruezinsky, D.3
Staudt, L.4
Gerhard, W.5
Weigert, M.6
-
31
-
-
0023161403
-
Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development
-
Allen, D., A. Cumano, R. Dildrop, C. Kocks, K. Rajewsky, N. Rajewsky, J. Roes, F. Sablitzky, and M. Siekevitz. 1987. Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development. Immunol. Rev. 96:5.
-
(1987)
Immunol. Rev.
, vol.96
, pp. 5
-
-
Allen, D.1
Cumano, A.2
Dildrop, R.3
Kocks, C.4
Rajewsky, K.5
Rajewsky, N.6
Roes, J.7
Sablitzky, F.8
Siekevitz, M.9
-
32
-
-
0023161406
-
Mutation drift and repertoire shift in the maturation of the immune response
-
Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23.
-
(1987)
Immunol. Rev.
, vol.96
, pp. 23
-
-
Berek, C.1
Milstein, C.2
-
33
-
-
0023161405
-
Evolution of antibody variable region structure during the immune response
-
Manser, T., L.J. Wysocki, M.N. Margolies, and M.L. Gefter. 1987. Evolution of antibody variable region structure during the immune response. Immunol. Rev. 96:141.
-
(1987)
Immunol. Rev.
, vol.96
, pp. 141
-
-
Manser, T.1
Wysocki, L.J.2
Margolies, M.N.3
Gefter, M.L.4
-
34
-
-
0023161407
-
Somatic mutation in anti-phosphorylcholine antibodies
-
Malipiero, U.V., N.S. Levy, and P.J. Gearhart. 1987. Somatic mutation in anti-phosphorylcholine antibodies. Immunol. Rev. 96:59.
-
(1987)
Immunol. Rev.
, vol.96
, pp. 59
-
-
Malipiero, U.V.1
Levy, N.S.2
Gearhart, P.J.3
-
35
-
-
0020635064
-
The immune response against anti-idiotope antibodies. II. The induction of antibodies bearing the target idiotope (Ab3/3) depends on the frequency of the corresponding B cells
-
Tesch, H., T. Takemori, and K. Rajewsky. The immune response against anti-idiotope antibodies. II. The induction of antibodies bearing the target idiotope (Ab3/3) depends on the frequency of the corresponding B cells. Eur. J. Immunol. 13:726.
-
Eur. J. Immunol.
, vol.13
, pp. 726
-
-
Tesch, H.1
Takemori, T.2
Rajewsky, K.3
-
36
-
-
0018179467
-
Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response
-
Reth, M., G.J. Hamerling, and K. Rajewsky. 1978. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur. J. Immunol. 8:393.
-
(1978)
Eur. J. Immunol.
, vol.8
, pp. 393
-
-
Reth, M.1
Hamerling, G.J.2
Rajewsky, K.3
-
38
-
-
0023920532
-
Detection of antibody, idiotype and anti-idiotype forming cells by in situ immunocytochemical staining
-
Brown, A.R., and E. Claassen. 1988. Detection of antibody, idiotype and anti-idiotype forming cells by in situ immunocytochemical staining. J. Immunol. Methods. 109:235.
-
(1988)
J. Immunol. Methods.
, vol.109
, pp. 235
-
-
Brown, A.R.1
Claassen, E.2
-
39
-
-
0022742672
-
Idiotype selection of an antibody mutant with changed hapten binding specificity resulting from a point mutation in position 50 of the heavy chain
-
Bruggeman, M., H.J. Muller, C. Burger, and K. Rajewsky. 1986. Idiotype selection of an antibody mutant with changed hapten binding specificity resulting from a point mutation in position 50 of the heavy chain. EMBO (Eur. Mol. Biol. Organ.) J. 5:1562.
-
(1986)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.5
, pp. 1562
-
-
Bruggeman, M.1
Muller, H.J.2
Burger, C.3
Rajewsky, K.4
-
40
-
-
0019952999
-
Somatic variants of murine immunoglobulin λ light chains
-
Bothwell, A.L.M., M. Paskind, M. Reth, T. Imanishi-Kari, K. Rajewsky, and D. Baltimore. 1982. Somatic variants of murine immunoglobulin λ light chains. Nature (Lond.). 298:380.
-
(1982)
Nature (Lond.)
, vol.298
, pp. 380
-
-
Bothwell, A.L.M.1
Paskind, M.2
Reth, M.3
Imanishi-Kari, T.4
Rajewsky, K.5
Baltimore, D.6
-
41
-
-
0004136246
-
-
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
-
Maniatis, T., E.F. Fritisch, and J. Sambrook. 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
-
(1982)
Molecular Cloning: A Laboratory Manual
-
-
Maniatis, T.1
Fritisch, E.F.2
Sambrook, J.3
-
42
-
-
0024222897
-
The de novo generation of germinal centres is an oligoclonal process
-
Kroese, F.G.M., A.S. Wubbena, H.G. Seijen, and P. Nieuwenhuis. 1988. The de novo generation of germinal centres is an oligoclonal process. Adv. Exp. Med. Biol. 237:245.
-
(1988)
Adv. Exp. Med. Biol.
, vol.237
, pp. 245
-
-
Kroese, F.G.M.1
Wubbena, A.S.2
Seijen, H.G.3
Nieuwenhuis, P.4
-
43
-
-
0021246815
-
Functional anatomy of germinal centers
-
Nieuwenhuis, P., and D. Opstelten. 1984. Functional anatomy of germinal centers. Am. J. Anat. 170:421.
-
(1984)
Am. J. Anat.
, vol.170
, pp. 421
-
-
Nieuwenhuis, P.1
Opstelten, D.2
-
44
-
-
0022909157
-
Is there a single differentiation pathway for all antibody-forming cells in the spleen?
-
Rooijen, N.V., E. Claassen, and P. Eikelenboom. 1986. Is there a single differentiation pathway for all antibody-forming cells in the spleen? Immunol. Today. 7:193.
-
(1986)
Immunol. Today
, vol.7
, pp. 193
-
-
Rooijen, N.V.1
Claassen, E.2
Eikelenboom, P.3
-
45
-
-
0025250237
-
Direct intrafollicular differentiation of memory cells into plasma cells
-
Rooijen, N.V. 1990. Direct intrafollicular differentiation of memory cells into plasma cells. Immunol. Today. 11:154.
-
(1990)
Immunol. Today
, vol.11
, pp. 154
-
-
Rooijen, N.V.1
-
46
-
-
0024495483
-
Primary in situ immune response in popliteal lymph nodes and spleen of mice after subcutaneous immunization with thymus-dependent or thymus-independent (Type 1 and 2) antigens
-
Delemarre, F.G.A., E. Claassen, and N.V. Rooijen. 1989. Primary in situ immune response in popliteal lymph nodes and spleen of mice after subcutaneous immunization with thymus-dependent or thymus-independent (Type 1 and 2) antigens. Anat. Rec. 223:152.
-
(1989)
Anat. Rec.
, vol.223
, pp. 152
-
-
Delemarre, F.G.A.1
Claassen, E.2
Rooijen, N.V.3
-
47
-
-
0008790010
-
The white pulp of the spleen. The relationship of arterial vessels, reticulum and free cells in the peripheral lymphatic sheath
-
Weiss, L. 1964. The white pulp of the spleen. The relationship of arterial vessels, reticulum and free cells in the peripheral lymphatic sheath. Bull. Johns Hopkins Hasp. 115:99.
-
(1964)
Bull. Johns Hopkins Hasp.
, vol.115
, pp. 99
-
-
Weiss, L.1
-
48
-
-
0021245797
-
The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light microscopic immunocytochemical studies of mouse spleen, lymph node and Peyer's patch
-
Witmer, M.D., and R.M. Steinman. 1984. The anatomy of peripheral lymphoid organs with emphasis on accessory cells: light microscopic immunocytochemical studies of mouse spleen, lymph node and Peyer's patch. Am. J. Anat. 170:465.
-
(1984)
Am. J. Anat.
, vol.170
, pp. 465
-
-
Witmer, M.D.1
Steinman, R.M.2
-
49
-
-
0005404413
-
Cell proliferation in germinal centers of rat spleen
-
Fliedner, TM., M. Kroese, E.P. Cronkite, and J.S. Robertson. 1964. Cell proliferation in germinal centers of rat spleen. Ann. NY Acad. Sci. 113:578.
-
(1964)
Ann. NY Acad. Sci.
, vol.113
, pp. 578
-
-
Fliedner, T.M.1
Kroese, M.2
Cronkite, E.P.3
Robertson, J.S.4
-
50
-
-
0018817713
-
Cell population kinetics of the germinal centers of lymph nodes of BALB/c mice
-
Zaitoun, A.M. 1980. Cell population kinetics of the germinal centers of lymph nodes of BALB/c mice. J. Anat. 130:131.
-
(1980)
J. Anat.
, vol.130
, pp. 131
-
-
Zaitoun, A.M.1
-
51
-
-
0021263922
-
The development of specific antibody-containing cells in the spleen of rabbits during the secondary immune response against free or liposome associated albumin antigen
-
Rooijen, N.V., R.V. Nieuwmegen, N. Kors, and P. Eikelenboom. 1984. The development of specific antibody-containing cells in the spleen of rabbits during the secondary immune response against free or liposome associated albumin antigen. Anat. Rec. 208:579.
-
(1984)
Anat. Rec.
, vol.208
, pp. 579
-
-
Rooijen, N.V.1
Nieuwmegen, R.V.2
Kors, N.3
Eikelenboom, P.4
-
52
-
-
0024338553
-
Early onset of somatic mutation in immunoglobulin V., genes during the primary immune response
-
Levy, N.S., U.V. Malipiero, S.G. Lebecque, and P.J. Gearhart. 1989. Early onset of somatic mutation in immunoglobulin V., genes during the primary immune response. J. Exp. Med. 169:2007.
-
(1989)
J. Exp. Med.
, vol.169
, pp. 2007
-
-
Levy, N.S.1
Malipiero, U.V.2
Lebecque, S.G.3
Gearhart, P.J.4
-
53
-
-
0025201892
-
Development of B cell lineages during a primary anti-hapten immune response
-
Tao, W., and A.L.M. Bothwell. 1990. Development of B cell lineages during a primary anti-hapten immune response. J. Immunol. 145:3216.
-
(1990)
J. Immunol.
, vol.145
, pp. 3216
-
-
Tao, W.1
Bothwell, A.L.M.2
-
54
-
-
0022802257
-
Clonal recruitment and somatic mutation in the generation of immunologic memory to the hapten NP
-
Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunologic memory to the hapten NP. EMBO (Eur. Mol. Biol. Organ.) J. 5:2459.
-
(1986)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.5
, pp. 2459
-
-
Cumano, A.1
Rajewsky, K.2
-
55
-
-
0023604840
-
A limited number of B cells lineages generates the heterogeneity of a secondary immune response
-
Blier, P.R., and A.L.M. Bothwell. 1987. A limited number of B cells lineages generates the heterogeneity of a secondary immune response. J. Immunol. 139:3996.
-
(1987)
J. Immunol.
, vol.139
, pp. 3996
-
-
Blier, P.R.1
Bothwell, A.L.M.2
-
56
-
-
0024044570
-
Antibody engineering for the analysis of affinity maturation on an anti-hapten response
-
Allen, D., T. Simon, F. Sablitzky, K. Rajewsky, and A. Cumano. 1988. Antibody engineering for the analysis of affinity maturation on an anti-hapten response. EMBO (Eur. Mol. Biol. Organ.) J. 7:1995.
-
(1988)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.7
, pp. 1995
-
-
Allen, D.1
Simon, T.2
Sablitzky, F.3
Rajewsky, K.4
Cumano, A.5
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