First-pass metabolism of cyclosporin by the gut

The Lancet

Volumn 338, Issue 8781, 1991, Pages 1488-1490

  Kolars, J C ^a   Watkins, P B ^a   Merion, R M ^a   Awni, W M ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A;

ADULT; ARTICLE; CASE REPORT; DRUG METABOLISM; GASTROINTESTINAL TRACT; HUMAN; LIVER TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL;

BIOLOGICAL AVAILABILITY; CYCLOSPORINE; HUMAN; INTESTINAL ABSORPTION; INTESTINE, SMALL; LIVER TRANSPLANTATION; PORTAL VEIN;

EID: 0025719746     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(91)92302-I     Document Type: Article

References (10)

1. Cyclosporine
2. Clinical pharmacokinetics of cyclosporin
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4. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
5. Optimized high-performance liquid chromatographic method for the analysis of cyclosporine and three of its metabolites in blood and unne
6. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificity of cDNA expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine
7. Role of cytochromes P450 in drug metabolism and hepatotoxicity
8. Cyclosporin-erythromycin interaction in renal transplant patients
9. Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450IIIA