Synthesis of nitric oxide from L-arginine: a recently discovered pathway induced by cytokines with antitumour and antimicrobial activity

Research in Immunology

Volumn 142, Issue 7, 1991, Pages 565-569

  Hibbs Jr , J B ^a  

^a Division of Infectious Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CYTOKINE; NITRIC OXIDE;

CONFERENCE PAPER; HUMAN; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL;

ANTIBIOTICS; ARGININE; CYTOKINES; ENZYME INDUCTION; MACROPHAGES; NITRIC OXIDE;

EID: 0025719538     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2494(91)90103-P     Document Type: Article

References (45)

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4. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
5. Localization of nitric oxide synthase indicating a neural role for nitric oxide
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7. Release of reactive nitrogen intermediates and reactive oxygen intermediates From mouse peritoneal macrophages
8. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible
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11. Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration
12. Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells
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14. Metabolic fate of L-arginine in relation to microbiostatic capability of macrophages
15. Activated macrophages destroy intracellular leishmania major amatigotes by an L-arginine-dependent killing mechanism
16. Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation
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28. Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells
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42. Characterization of the effect of endotoxin on macrohage tumor cell killing
43. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts