Effect of ascorbic acid and its synthetic lipophilic derivative ascorbyl palmitate on phorbol ester-induced skin-tumor promotion in mice

American Journal of Clinical Nutrition

Volumn 54, Issue SUPPL. 6, 1991, Pages

  Smart, Robert C ^a   Crawford, Catherine L ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Anticarcinogens; Diet; Multistage carcinogensis; Vitamin C

Indexed keywords

ASCORBIC ACID; ASCORBYL PALMITATE; PHORBOL ESTER;

ANIMAL EXPERIMENT; CARCINOGENESIS; CONFERENCE PAPER; DIET; FEMALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SKIN CANCER; TOPICAL DRUG ADMINISTRATION;

ANIMAL; ASCORBIC ACID; DIET; DNA; EPIDERMIS; FEMALE; MICE; MICE, INBRED STRAINS; ORNITHINE DECARBOXYLASE; OSMOLAR CONCENTRATION; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 0025718709     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/54.6.1266s     Document Type: Article

References (27)

1. Peto RM, Roe FJC, Lee PN, Levy L, Clack J. Cancer and ageing in mice and man. Br J Cancer 1975;32:411-26.
2. Fearon ER, Volgelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;16:759-67.
3. Boutwell RK. Some biological aspects of skin carcinogenesis. Prog Exp Tumor Res 1964;4:207-50.
4. Boutwell RK. The structure and metabolism of the promoters of carcinogenesis. CRC Crit Rev Toxicol 1974;2:419-43.
5. Hecker E, Fusenig NE, Kuntz W, Marks F, Thielmann HW, eds. Cocarcinogensis and the biological effect of tumor promoters. Vol 7. New York: Raven Press, 1982.
6. Borzsonyi M, Day NE, Lapis K, Yamaski H, eds. Models, mechanisms and etiology of tumor promotion. Publication 56. Lyon, France: International Agency for Research on Cancer, 1984.
7. Egner PA, Kensler TW. Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin. Carcinogenesis (Lond) 1985;6:1167-72.
8. Slaga TJ, Klein-Szanto AJP, Triplett LL, Yotti LP, Trosko JE. Skin tumor-promotion activity of benzoyl peroxide, a widely used free radical-generating compound. Science 1981;213:1023-5.
9. Copeland ES, ed. Free radicals in promotion - a chemical pathology study section workshop. Cancer Res 1983;43:5631-7.
10. Slaga TJ, Solanki V, Logani M. Studies on the mechanism of action of antitumor promoting agents: suggestive evidence for the involvement of free radicals in promotion. In: Nygaard OF, Smic MG, eds. Radioprotectors and anticarcinogens. New York: Academic Press, 1983:471-85.
11. Kozumbo WJ, Seed JL, Kensler TW. Inhibition by 2(3)-tertbutyl-4-hydroxyanisole and other antioxidants of epidermal ornrthine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 1983;43:2555-9.
12. Shamberger RJ. Increase of peroxidation in carcinogenesis. J Natl Cancer Inst 1972;48:1491-7.
13. Perchellet J-P, Owen MD, Posey TD, Orten DK, Schneider BA. Inhibitory effects of glutathione level-raising agents and D-α-tocopherol on ornithme decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13 acetate. Carcinogenesis (Lond) 1985;6:567-73.
14. Kato R, Nakadate T, Yamamoto S, Sugimura T. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithme decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenesis (Lond) 1983;4:1301-5.
15. Huang M-T, Smart RC, Wong C-Q, Conney AH. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 1988;48:5941-6.
16. Slaga TJ, Fischer SM. Strain differences and solvent effects in mouse skin carcinogenesis experiments using carcinogens, tumor initiators and promoters. Prog Exp Tumor Res 1983;26:85-109.
17. Som S, Raha C, Chatterjee IB. Ascorbic acid: a scavenger of superoxide radical. Acta Vitaminol Enzymol 1983;5:243-50.
18. Chan JT, Black HS. The mitigating effect of dietary antioxidants on chemically-induced carcinogenesis. Experientia 1978;34:110-1.
19. Dunham WB, Zuckerkandl E, Reynolds R, et al. Effects of intake of L-ascorbic acid on the incidence of dermal neoplasm induced in mice by ultraviolet light. Proc Natl Acad Sci USA 1982;79:7532-6.
20. Gol-Winkler R, De Clerck Y, Gielen JE. Ascorbic acid effect on methylcholanthrene-induced transformation of C3H10T1/2 clone 8 cells. Toxicology 1980;17:237-9.
21. Benedict WF, Wheately WL, Jones PA. Inhibition of chemically induced morphological transformation and reversion of the transformed phenotype by ascorbic acid in C3H/10T1/2 cells. Cancer Res 1980;40:2796-801.
22. Smart RC, Huang M-T, Han Z-T, Kaplan MC, Focella A, Conney AH. Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of ornithine decarboxylase, DNA synthesis and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate. Cancer Res 1987;47:6633-8.
23. Slaga TJ, Das SB, Rice JM, Thompson S. Fractionation of mouse epidermal chromatin components. J Invest Dermatol 1974;63: 343-9.
24. Smart RC, Huang M-T, Conney AH. sn-I,2-Diacylglycerols mimic the effects of 12-O-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. Carcinogenesis (Lond) 1986;7:1865-70.
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein determination with folin phenol reagent. J Biol Chem 1951;193:291-4.
26. Zannoni V, Lynch M, Goldstein S, Sato PA. A rapid micromethod for the determination of ascorbic acid in plasma and tissues. Biochem Med 1974;11:41-8.
27. Witt JJ, Roskoski R Jr. Rapid protein kinase assay using phosphocellulose-paper absorption. Anal Biochem 1975;66:253-8.