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Volumn 50, Issue 23, 1990, Pages 7483-7489

Metabolism of Mitomycin C by DT-Diaphorase: Role in Mitomycin C-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

Author keywords

[No Author keywords available]

Indexed keywords

DICOUMAROL; DIHYDROLIPOAMIDE DEHYDROGENASE; MITOMYCIN C;

EID: 0025688249     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (230)

References (51)
  • 2
    • 84913403965 scopus 로고
    • Mitomycin C: chemical and biological studies on alkylation
    • Schwartz, H. S., Sodergren, J. E., and Philips, F. S. Mitomycin C: chemical and biological studies on alkylation. Science (Washington DC), 42: 1181–1183, 1963.
    • (1963) Science (Washington DC) , vol.42 , pp. 1181-1183
    • Schwartz, H.S.1    Sodergren, J.E.2    Philips, F.S.3
  • 3
    • 84883312556 scopus 로고
    • Mitomycins and porf�romycin: chemical mechanism of activation and crosslinking of DNA
    • Iyer, V. N., and Szybalski, W. Mitomycins and porf�romycin: chemical mechanism of activation and crosslinking of DNA. Science (Washington DC), 45: 55–58, 1964.
    • (1964) Science (Washington DC) , vol.45 , pp. 55-58
    • Iyer, V.N.1    Szybalski, W.2
  • 4
    • 0001896852 scopus 로고
    • Potential bioreductive alkylating agents
    • Washington D. C.: American Chemical Society
    • Lin, A. J., Cosby, L. A., and Sartorelli, A. C. Potential bioreductive alkylating agents, n: A. C. Sartorelli (ed.). Cancer Chemotherapy, pp. 71–86. Washington D. C.: American Chemical Society, 1976.
    • (1976) Cancer Chemotherapy , pp. 71-86
    • Lin, A.J.1    Cosby, L.A.2    Sartorelli, A.C.3
  • 5
    • 0023547926 scopus 로고
    • Metabolism and reactions of quinoid anticancer agents
    • Powis, G. Metabolism and reactions of quinoid anticancer agents. Pharmacol. Ther., 35: 57–162, 1987.
    • (1987) Pharmacol. Ther. , vol.35 , pp. 57-162
    • Powis, G.1
  • 6
    • 0022511678 scopus 로고
    • DNA alkylation by enzyme activated mitomycin C
    • Pan, S. S., Iracki, T., and Bachur, N. R. DNA alkylation by enzyme activated mitomycin C. Mol. Pharmacol., 29: 622–628, 1986.
    • (1986) Mol. Pharmacol. , vol.29 , pp. 622-628
    • Pan, S.S.1    Iracki, T.2    Bachur, N.R.3
  • 7
    • 0023136662 scopus 로고
    • Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semi-quinone as the active electrophile
    • Egbertson M., and Danishefsky S. J. Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semi-quinone as the active electrophile. J. Am. Chem. Soc., 09: 2204–2205, 1987.
    • (1987) J. Am. Chem. Soc. , pp. 2204-2205
    • Egbertson, M.1    Danishefsky, S.J.2
  • 9
    • 0019724691 scopus 로고
    • Naturally occurring qui�ones as potential bioreductive alkylating agents
    • Moore, H. W., and Czemiak, R. Naturally occurring qui�ones as potential bioreductive alkylating agents. Med. Res. Rev., 1: 249–280, 1981.
    • (1981) Med. Res. Rev. , vol.1 , pp. 249-280
    • Moore, H.W.1    Czemiak, R.2
  • 10
    • 0018565997 scopus 로고
    • Binding mode of chemically activated semiquinone free radicals from quinone anticancer agents to DNA
    • Sinha, B. K., and Chignell, C. F. Binding mode of chemically activated semiquinone free radicals from quinone anticancer agents to DNA. Chem. Biol. Interact., 28: 301–308, 1979.
    • (1979) Chem. Biol. Interact. , vol.28 , pp. 301-308
    • Sinha, B.K.1    Chignell, C.F.2
  • 11
    • 0020385188 scopus 로고
    • Generation of hydroxyl radical by anticancer quinone drugs carbazilquinone, mitomycin C., aclacinomycin A and Adriamycin in the presence of NADPH cytochrome P450 reductase
    • Komiyama, T., Kikuchi, T., and Sugiura, Y. Generation of hydroxyl radical by anticancer quinone drugs carbazilquinone, mitomycin C., aclacinomycin A and Adriamycin in the presence of NADPH cytochrome P450 reductase. Biochem. Pharmacol., 37: 3651–3656, 1982.
    • (1982) Biochem. Pharmacol. , vol.37 , pp. 3651-3656
    • Komiyama, T.1    Kikuchi, T.2    Sugiura, Y.3
  • 12
    • 0001213485 scopus 로고
    • Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich cancer cells by antitumor qui�ones
    • Doroshow, J. H. Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich cancer cells by antitumor qui�ones. Proc. Natl. Acad. Sci. USA, 3: 4514–4518 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.3 , pp. 4514-4518
    • Doroshow, J.H.1
  • 13
    • 0024453625 scopus 로고
    • DNA damage, cytotoxicity and free radical formation by mitomycin C in human cells
    • Dusre, L., Covey, J. M., Collins, C., and Sinha, B. K. DNA damage, cytotoxicity and free radical formation by mitomycin C in human cells. Chem. Biol. Interact., 77: 63–78, 1989.
    • (1989) Chem. Biol. Interact. , vol.77 , pp. 63-78
    • Dusre, L.1    Covey, J.M.2    Collins, C.3    Sinha, B.K.4
  • 14
    • 0021962149 scopus 로고
    • Reactions of the semiquinone free radicals of antitumour agents with oxygen and iron complexes
    • Butler, J., Hoey, B. M., and Swallow, A. J. Reactions of the semiquinone free radicals of antitumour agents with oxygen and iron complexes. FEBS Utt., 82: 95–98, 1985.
    • (1985) FEBS Utt. , vol.82 , pp. 95-98
    • Butler, J.1    Hoey, B.M.2    Swallow, A.J.3
  • 15
    • 0022508898 scopus 로고
    • Autocatalytic quinone methide formation from mitomycin C
    • Peterson, D. W., and Fisher, J. Autocatalytic quinone methide formation from mitomycin C. Biochemistry, 25: 4077–4084, 1986.
    • (1986) Biochemistry , vol.25 , pp. 4077-4084
    • Peterson, D.W.1    Fisher, J.2
  • 17
    • 0019835111 scopus 로고
    • Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes
    • Tomasz, M., and Lipman, R. Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes. Biochemistry, 20: 5056–5061, 1981.
    • (1981) Biochemistry , vol.20 , pp. 5056-5061
    • Tomasz, M.1    Lipman, R.2
  • 18
    • 18244424675 scopus 로고
    • Metabolic activation of mitomycin C by isolated liver nuclei and microsomes
    • Kennedy, K. A., and Sartorelli, A. C., Metabolic activation of mitomycin C by isolated liver nuclei and microsomes. Fed. Proc., 38: 443, 1979.
    • (1979) Fed. Proc. , vol.38 , pp. 443
    • Kennedy, K.A.1    Sartorelli, A.C.2
  • 19
    • 0019992640 scopus 로고
    • Metabolic activation of mitomycin C by liver microsomes and nuclei
    • Kennedy, K. A., Sligar, S. G., Polomski, L., and Sartorelli, A. C. Metabolic activation of mitomycin C by liver microsomes and nuclei. Biochem. Pharmacol., 37: 2011–2016, 1982.
    • (1982) Biochem. Pharmacol. , vol.37 , pp. 2011-2016
    • Kennedy, K.A.1    Sligar, S.G.2    Polomski, L.3    Sartorelli, A.C.4
  • 20
    • 0021345793 scopus 로고
    • Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH cytochrome P450 reductase and xanthine oxidase
    • Pan, S. S., Andrews, P. A., Glover, C. J., and Bachur, N. R. Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH cytochrome P450 reductase and xanthine oxidase. J. Biol. Chem., 259: 959–966, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 959-966
    • Pan, S.S.1    Andrews, P.A.2    Glover, C.J.3    Bachur, N.R.4
  • 21
    • 0000684751 scopus 로고
    • Alkylation reactions of mitomycin C at acid pH
    • Tomasz, M., and Lipman, R. Alkylation reactions of mitomycin C at acid pH. J. Am. Chem. Soc., 707: 6063–6067, 1979.
    • (1979) J. Am. Chem. Soc. , vol.707 , pp. 6063-6067
    • Tomasz, M.1    Lipman, R.2
  • 22
    • 0022514628 scopus 로고
    • Reassignment of the guanine binding mode of reduced mitomycin C
    • Tomasz, M., Lipman. R., Verdine, G. L., and Nakanishi, K. Reassignment of the guanine binding mode of reduced mitomycin C. Biochemistry, 25: 4337–4344, 1986.
    • (1986) Biochemistry , vol.25 , pp. 4337-4344
    • Tomasz, M.1    Lipman, R.2    Verdine, G.L.3    Nakanishi, K.4
  • 23
    • 0023154027 scopus 로고
    • Covalent binding of mitomycin C to nucleosides under reductive conditions
    • Zein, N., and Kohn, H. Covalent binding of mitomycin C to nucleosides under reductive conditions. J. Am. Chem. Soc., 09: 1576–1577, 1987.
    • (1987) J. Am. Chem. Soc. , pp. 1576-1577
    • Zein, N.1    Kohn, H.2
  • 26
    • 0022007423 scopus 로고
    • pH-dependence of mitomycin C-induced cross linking activity in EMT6 tumor cells
    • Kennedy, K. A., McGurl, J. D., Leondaridis, L., and Alabaster, O. pH-dependence of mitomycin C-induced cross linking activity in EMT6 tumor cells. Cancer Res., 45: 3541–3547, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 3541-3547
    • Kennedy, K.A.1    McGurl, J.D.2    Leondaridis, L.3    Alabaster, O.4
  • 27
    • 0001072228 scopus 로고
    • DT-diaphorase
    • Emster, L. DT-diaphorase. Methods Enzymol., 8: 309–317, 1967.
    • (1967) Methods Enzymol. , vol.8 , pp. 309-317
    • Emster, L.1
  • 28
    • 0021934520 scopus 로고
    • Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro
    • Keyes, S. R., Rockwell, S., and Sartorelli, A. C. Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro. Cancer Res., 45: 213–216, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 213-216
    • Keyes, S.R.1    Rockwell, S.2    Sartorelli, A.C.3
  • 29
    • 0023682539 scopus 로고
    • Mitomycin C is not metabolized but is an inhibitor of human kidney NAD(P)H: (quinone acceptor) oxidoreductase
    • Schlager, J. J., and Powis, G. Mitomycin C is not metabolized but is an inhibitor of human kidney NAD(P)H: (quinone acceptor) oxidoreductase. Cancer Chemother. Pharmacol., 22: 126–130, 1988.
    • (1988) Cancer Chemother. Pharmacol. , vol.22 , pp. 126-130
    • Schlager, J.J.1    Powis, G.2
  • 30
    • 0342621398 scopus 로고
    • Relationship between the antioxidant enzyme DT-diaphorase and tumor response to mitomycin C treatment
    • New York: Plenum Press
    • Pritsos, C. A., Pardini, L. L., Elliott, A. J., and Pardini, R. S. Relationship between the antioxidant enzyme DT-diaphorase and tumor response to mitomycin C treatment, n: M. G. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag (eds.). Oxygen Radicals in Biology and Medicine, pp. 713–716. New York: Plenum Press, 1987.
    • (1987) Oxygen Radicals in Biology and Medicine , pp. 713-716
    • Pritsos, C.A.1    Pardini, L.L.2    Elliott, A.J.3    Pardini, R.S.4
  • 31
    • 0024328012 scopus 로고
    • Increased sensitivity of quinone resistant cells to mitomycin C
    • Begleiter, A., Robotham, E., Lacey, G., and Leith, M. K. Increased sensitivity of quinone resistant cells to mitomycin C. Cancer Lett., 45: 173–176, 1989.
    • (1989) Cancer Lett. , vol.45 , pp. 173-176
    • Begleiter, A.1    Robotham, E.2    Lacey, G.3    Leith, M.K.4
  • 32
    • 0024557260 scopus 로고
    • Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions
    • Marshall, R. S., Paterson, M. C., and Rauth, A. M. Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions. Br. J. Cancer, 59: 341–346, 1989.
    • (1989) Br. J. Cancer , vol.59 , pp. 341-346
    • Marshall, R.S.1    Paterson, M.C.2    Rauth, A.M.3
  • 33
    • 0024492336 scopus 로고
    • Isolation of Chinese hamster ovary cells deficient in excision repair and mitomycin C bioactivation
    • Dulhanty, A. M., Li, M., and Whitmore, G. F. Isolation of Chinese hamster ovary cells deficient in excision repair and mitomycin C bioactivation. Cancer Res., 49: 117–122, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 117-122
    • Dulhanty, A.M.1    Li, M.2    Whitmore, G.F.3
  • 34
    • 0024313837 scopus 로고
    • DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs
    • Workman, P., Walton, M. I., Powis, G., and Schlager, J. J. DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs. Br. J. Cancer, 60: 800–802, 1989.
    • (1989) Br. J. Cancer , vol.60 , pp. 800-802
    • Workman, P.1    Walton, M.I.2    Powis, G.3    Schlager, J.J.4
  • 35
  • 36
    • 0024491935 scopus 로고
    • Characterization of DNA damage and cytotoxicity induced in two human colon carcinoma cell lines by cyclodisone
    • Gibson, N. W. Characterization of DNA damage and cytotoxicity induced in two human colon carcinoma cell lines by cyclodisone. Cancer Res., 49: 154–157, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 154-157
    • Gibson, N.W.1
  • 39
    • 0019142866 scopus 로고
    • Increase of NAD(P)H: quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity
    • Benson, A. M., Hunkier, M. J., and Talalay, P. Increase of NAD(P)H: quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. USA, 77: 5216–5220, 1980.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 5216-5220
    • Benson, A.M.1    Hunkier, M.J.2    Talalay, P.3
  • 41
    • 0025258497 scopus 로고
    • Metabolism of diaziquone by NAD(P)H: (quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells
    • Siegel, D., Gibson, N. W., Prusch, P., and Ross, D. Metabolism of diaziquone by NAD(P)H: (quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res., 50: 7293–7300, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 7293-7300
    • Siegel, D.1    Gibson, N.W.2    Prusch, P.3    Ross, D.4
  • 43
    • 0019778223 scopus 로고
    • Determination of pyridine nucleotides in cell extracts by high performance liquid chromatography
    • Jones, D. P. Determination of pyridine nucleotides in cell extracts by high performance liquid chromatography. J. Chromatogr., 225: 446–449, 1981.
    • (1981) J. Chromatogr. , vol.225 , pp. 446-449
    • Jones, D.P.1
  • 44
    • 0019532613 scopus 로고
    • DNA strand scission by enzymatically generated oxygen radicals
    • Brown, K., and Fridovitch, I. DNA strand scission by enzymatically generated oxygen radicals. Arch. Biochem. Biophys., 206: 414–419, 1981.
    • (1981) Arch. Biochem. Biophys. , vol.206 , pp. 414-419
    • Brown, K.1    Fridovitch, I.2
  • 46
    • 0024278435 scopus 로고
    • Reductive activation of mitomycin C
    • Hoey, B. M., Butler, J., and Swallow, A. J. Reductive activation of mitomycin C. Biochemistry, 27: 2608–2614, 1988.
    • (1988) Biochemistry , vol.27 , pp. 2608-2614
    • Hoey, B.M.1    Butler, J.2    Swallow, A.J.3
  • 47
    • 0021687360 scopus 로고
    • Role of NADPH: cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C
    • Keyes, S. R., Fracasso, P. M., Heimbrook, D. C., Rockwell, S., Sligar, S. G., and Sartorelli, A. C. Role of NADPH: cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C. Cancer Res., 44: 5638–5643, 1984.
    • (1984) Cancer Res. , vol.44 , pp. 5638-5643
    • Keyes, S.R.1    Fracasso, P.M.2    Heimbrook, D.C.3    Rockwell, S.4    Sligar, S.G.5    Sartorelli, A.C.6
  • 48
    • 0023774903 scopus 로고
    • Modulation of the cytotoxicity of mitomycin C by dicoumarol in vitro
    • Rockwell, S., Keyes, S. R., and Sartorelli, A. C. Modulation of the cytotoxicity of mitomycin C by dicoumarol in vitro. Cancer Res., 48: 5471–5474, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 5471-5474
    • Rockwell, S.1    Keyes, S.R.2    Sartorelli, A.C.3
  • 49
    • 0024475230 scopus 로고
    • Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells
    • Keyes, S. R., Rockwell, S., and Sartorelli, A. C. Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells. Cancer Res., 49: 3310–3313, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 3310-3313
    • Keyes, S.R.1    Rockwell, S.2    Sartorelli, A.C.3
  • 50
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors
    • Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors. A review. Cancer Res., 49: 6449–6465, 1989.
    • (1989) A review. Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 51
    • 0018852436 scopus 로고
    • Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells
    • Kennedy, K. A., Rockwell, S., and Sartorelli, A. C. Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res., 40: 2356–2360, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 2356-2360
    • Kennedy, K.A.1    Rockwell, S.2    Sartorelli, A.C.3


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