Influence of hormones and drugs on glutathione-S-transferase levels in primary culture of adult rat hepatocytes

Cell Biology and Toxicology

Volumn 6, Issue 4, 1990, Pages 365-378

  Gebhardt, Rolf ^a   Fitzke, Helga ^a   Fausel, Martina ^a   Eisenmann Tappe, Iris ^a   Mecke, Dieter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

GST Ya1; GST Yb1; GST Yp; hyaluronidase; methylcholanthrene; nicotinamide; phenobarbital

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 3 METHYLCHOLANTHRENE; DEXAMETHASONE; ESTRADIOL; GLUCAGON; GLUTATHIONE TRANSFERASE; INSULIN; LIOTHYRONINE; PHENOBARBITAL; PROGESTERONE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; LIVER CELL CULTURE; MALE; NONHUMAN; RAT;

ANIMAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; GLUTATHIONE TRANSFERASE; HORMONES; LIVER; METHYLCHOLANTHRENE; PHENOBARBITAL; RATS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

ANIMALIA;

EID: 0025679098     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/BF00120803     Document Type: Article

References (46)

1. Differential regulation of glutathione-S-transferases in cultured hepatocytes
2. Ligandin heterogeneity: evidence that the two non-identical subunits are the monomers of two distinct proteins
3. Evidence that the Ya and Yc subunits of glutathione transferase B (Ligandin) are the products of separate genes
4. Prolonged maintenances of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type
5. Use of primary cultures of human hepatocytes in toxicology studies
6. Activities of several phase I and phase II xenobiotic biotransformation enzymes in cultured hepatocytes from male and female rats
7. Translation in vitro of rat liver messenger RNA coding for ligandin (glutathione-S-transferase B)
8. Transcriptional regulation of rat liver glutathione-S-transferase genes by phenobarbital and 3-methylcholanthrene
9. Rat liver glutathione-S-transferases. DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital
10. Isolierte Gallengangs-Epithelzellen verfügen über einen induzierbaren Na+-abhängigen Glutamattransport mit einer zu Hepatozyten inversen Regulation durch Dexamethason
11. Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis
12. The role of growth hormone, dexamethasone and triiodothyronine in the regulation of glutamine synthetase in primary cultures of rat hepatocytes
13. Biliary secretion of sodium fluorescein in primary cultures of adult rat hepatocytes and its stimulation by nicotinamide
14. Cellular distribution and regulation of glutamine synthetase in liver
15. Use of isolated and cultured hepatocytes in studies on bile formation
16. Selective loss of hormonal induction of glutamate transport in primary cultures of hepatocytes from rats treated with CCl4
17. Use of isolated and cultured hepatocytes for xenobiotic metabolism and cytotoxicity studies
18. Isoenzymes of glutathione transferase in rat kidney cytosol
19. Assays for differentiation of glutathione-Stransferases
20. Drug metabolism activities of isolated rat hepatocytes in monolayer culture
21. The enzymatic preparation of isolated intact parenchymal cells from rat liver
22. Rat glutathione-S-transferase. Cloning of double-stranded cDNA and Induction of its mRNA
23. Condictions affecting primary cultures of functional adult rat hepatocytes I. Dexamethasone enhanced longevity and maintenance of morphology
24. Growth state-dependent phenotypes of adult hepatocytes in primary monolayer culture
25. Protein measurement with the folin phenol reagent
26. Development of in vitro toxicity tests with cultures of freshly isolated rat hepatocytes
27. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties
28. Use of hepatocytes for studies of mutagenesis and carcinogenesis
29. Single GST-P positive liver cells-putative initiated hepatocytes
30. Dose-related effects of phenobarbital on hepatic glutathion-S-transferase activity and ligandin levels in the rat
31. Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: Effect of drugs, chemicals, hormones and cholestasis
32. Regulation of glutathione-S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
33. The placental form of glutathione-S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis
34. Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix
35. Dexamethasone restores hormonal inducibility of ornithine decarboxylase in primary cultures of rat hepatocytes
36. Mono-oxygenase and glucuronyltransferase activities in short term cultures of isolated rat hepatocytes
37. Preparation of isolated rat liver cells
38. Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon meshes
39. Relative merits of immunohistochemical demonstration of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of gamma glutamyltrans peptidase as markers of altered foci during liver carcinogenesis in rats
40. Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression
41. Influence of medium composition and culture conditions on glutathione Stransferase activity in adult rat hepatocytes during culture
42. Glutathione transferase isoenzymes in cultured rat hepatocytes
43. Effect of phenobarbital on the expression of glutathione S-transferase isoenzymes in cultured rat hepatocytes
44. Biochemical and biological indices of the toxicity of xenobiotics in liver cell cultures
45. Long-term cell culture of adult rat liver epithelial cells