Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

The Journal of Pathology

Volumn 162, Issue 4, 1990, Pages 285-294

  Hall, P A ^a   Levison, D A ^b   Woods, A L ^b   Yu, C C W ^b   Kellock, D B ^b   Watkins, J A ^b   Barnes, D M ^b   Gillett, C E ^b   Camplejohn, R ^c   Dover, R ^a   Waseem, N H ^a   Lane, D P ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

autocrine; cell proliferation; growth factors; immunohistochemistry; PCNA

Indexed keywords

NUCLEAR PROTEIN;

ARTICLE; CANCER CELL; CELL GROWTH; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

ADULT; ANIMAL; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; BREAST NEOPLASMS; CELL DIVISION; FIXATIVES; FROZEN SECTIONS; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPHOMA, NON-HODGKIN; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; PROLIFERATING CELL NUCLEAR ANTIGEN; RABBITS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0025678485     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1711620403     Document Type: Article

References (39)

1. Assessment of cell proliferation in histological material
2. Immunohistological markers of cell proliferation: Achievements, problems and prospects
3. Autoantibodies to a nuclear antigen in proliferating cells
4. A nuclear antigen associated with cell proliferation and blast transformation. Its distribution in synchronised cells
5. Proliferating cell nuclear antigen (PCNA) and human malignant nucleolar antigens (HMTNA) in nucleoli of human haematological malignancies
6. Cyclin: a nuclear protein whose level correlates directly with the proliferative state of normal as well as transformed cells
7. Cell cycle dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase
8. Identity of the proliferating cell nuclear antigen and cyclin
9. Cloning and sequence of the human nuclear protein cyclin: homology with DNA binding proteins
10. Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen gene
11. Importance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene
12. Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors
13. Induction of the nuclear protein cyclin in quiescent mouse 3T3 cells stimulated by serum and growth factors. Correlation with DNA synthesis
14. Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication
15. Analysis of proliferative grade using anti‐PCNA‐cylcin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis
16. Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues
17. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form
18. Heterogeneity and cell cycle analyses from time‐lapse studies of human keratinocytes in vitro
19. Measurement of the rate of epidermal terminal diffrentation: expression of involucrin by S phase keratinocytes in culture and in psoriatic plaques
20. Quantitation and subcellular localisation of proleferating cell nuclear antigen (PCNA/cyclin) in oocytes and eggs of Xenopus laevis
21. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites
22. Application of proliferating cell nuclear antigen (PCNA) immunostaining in gastric cancer (abstract)
23. Immunohistochemical staining with a monoclonal antibody to proliferating cell nuclear antigen may be a good indicator of prognosis in haemangiopericytomas (abstract)
24. A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells
25. Identification of a nuclear and of a cytoplasmic polypeptide whose relative proportion are sensitive to changes in the rate of proliferation
26. An auxiliary protein for DNA polymerase‐δ from foetal calf thymus
27. Functional identity of proliferating cell nuclear antigen and DNA polymerase‐δ auxiliary protein
28. Cyclin‐PCNA is the auxiliary protein of DNA polymerase‐δ
29. Involvement of proliferating cell nuclear antigen (cyclin) in DNA replication in living cells
30. Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin
31. Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA
32. DNA polymerase‐δ/PCNA: actions and interactions
33. Increased nuclear cyclin/PCNA antigen staining of non‐S phase transformed human amnion cells engaged in nucleotide excision DNA repair
34. Changes in cyclin/PCNA distribution during DNA repair synthesis
35. Gene for proliferating cell nuclear antigen (DNA polymerase‐δ auxiliary protein) is present in both mammalian and higher plant genomes
36. Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication
37. Regulation of proliferating cell nuclear antigen during the cell cycle
38. The prognostic value of PCNA (proliferating cell nuclear antigen) immunostaining in gastrointestinal lymphomas (abstract)
39. Endothelioma cells expressing the polyoma middle T antigen induce hemangiomas by host cell recruitment