A repeated proline-rich sequence in Sm B/B′ and N is a dominant epitope recognized by human and murine autoantibodies

Journal of Autoimmunity

Volumn 3, Issue 6, 1990, Pages 715-725

  Williams, David G ^a   Sharpe, Neil G ^b   Wallace, Graham ^c   Latchman, David S ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CELL NUCLEUS ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; CLINICAL ARTICLE; HUMAN; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; EPITOPES; HUMAN; MICE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T;

EID: 0025676094     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/S0896-8411(05)80038-1     Document Type: Article

References (14)

1. Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine
2. The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing
3. Murine lupus monoclonal antibodies define five epitopes on two different Sm polypeptides
4. Isolation of cDNA clones encoding the human Sm B/B′ autoimmune antigen and specifically reacting with human anti-Sm autoimmune sera
5. Cloned human snRNP proteins B and B′ differ only in their carboxy-terminal part
6. A comparison of snRNP-associated Sm-autoantigens: human N, rat nN and human B/B′
7. Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis
8. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
9. The 9-fluorenylmethoxycarbonyl amino-protecting group
10. Preparative isolation of p67, A, B, B′ and D from nRNP/Sm and Sm antigens by reverse phase chromatography: Use in a polypeptide-specific ELISA for independent quantitation of anti-RNP and anti-Sm antibodies
11. Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B-cell epitopes
12. Interactions between autoimmunity and molecular and cell biology. Bridges between clinical and basic sciences
13. Autoantibodies to the Sm antigen
14. Individual variation of anti-Sm autoantibodies in the MRL/MP-lpr/lpr mouse: age-related increase in diversity