Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

Free Radical Biology and Medicine

Volumn 9, Issue 4, 1990, Pages 315-325

  Stadtman, Earl R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Aging Metal ion catalysis; Oxygen free radicals; Protein carbonyl groups; Protein modification; protein oxidation and diseases; Protein turnover; Site specific radical formation

Indexed keywords

ENDOGENOUS COMPOUND; FREE RADICAL; IRON;

AGING; ALCOHOLISM; ANIMAL TISSUE; ARTICLE; BACTERIUM; CATARACT; CATTLE; CHICKEN; ERYTHROCYTE; HORSE; LENS; LIVER; LUNG EMPHYSEMA; MUSCLE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN MODIFICATION; RABBIT; RAT; RETICULOCYTE; RHEUMATOID ARTHRITIS; STRESS; YEAST;

AGING; ANIMAL; COPPER; FERROUS COMPOUNDS; FREE RADICALS; HUMAN; OXIDATION-REDUCTION; OXYGEN; PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS); BOS TAURUS; EQUUS CABALLUS; GALLUS GALLUS; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0025674536     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(90)90006-5     Document Type: Article

References (113)

1. Effect of ionizing radiation on proteins, RCO groups, peptide bond cleavage, inactivation -SH oxidation
2. Radiation-induced oxidation of protein in aqueous solution
3. Oxygen effect in radiolysis of proteins Part 2. Bovine serum albumin
4. Modification of hepatic proteins in rats exposed to high oxygen concentration
5. Measurement and characterization of postischemic free radical generation in the isolated perfused heart
6. Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate
7. Measurement of superoxide-derived free radicals in the perfused heart
8. Ischemia/reperfusion induced free radical formation as asessed by spin-trapping and oxidative damage
9. Tissue destruction by neutrophils
10. Immune complexes, oxygen radicals, and lung injury
11. Regulation of glutamine synthetase degradation
12. Turnover of bacterial glutamine synthetase: Oxidative inactivation precedes proteolysis
13. Regulation of glutamine synthetase aspartokinase, and total protein turnover in Klebsiella aerogenes
14. Oxidation of proteins by mixed-function oxidation systems: Implication in protein turnover, ageing and neutrophil function
15. Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing
16. Inactivation of Escherichia coli gluatmine synthetase by xanthine oxidase, nicotinate hydroxylate, horseradish peroxidase, or glucose oxidase: effects of ferredoxin, putaredoxin, and menadione
17. Effect of oxygen radicals and hyperoxia on rat heart ornithine decarboxylase activty
18. Inactivation of glutamine synthetase by a purified rabbit liver microsomal cytochrome P-450 system
19. Vit C·Fe(III)-induced loss of the covalently bound phosphate and enzyme activity of phosphoglucomutase
20. The analogous mechanisms of enzymatic inactivation induced by ascorbate and superoxide in the presence of copper
21. − and lack of inactivation of ornithine transcarbamylase
22. Studies on ascorbic acid. I. Factors influencing teh ascorbate-mediated inhibition of catalase
23. Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system
24. Age-related alterations of enzymes may involve mixed-function oxidation reactions
25. Benzyl viologen-mediated in vivo and in vitro inactivation of glutamine synthetase in Azotobacter chrococcum
26. Oxidative modification of proteins in the presence of ferrous ion and air. Effect of ionic constituents of the reaction medium on the nature of the oxidation products
27. Studies of the limited degradation of mucus glycoproteins. The mechanism of the peroxide reaction
28. Studies on the limited degradation of mucus glycoproteins: the effect of dilute hydrogen peroxide
29. Different selectivities of oxidants during oxidation of methionine residues in the α-1-proteinase inhibitor
30. Lipid peroxidation inactivates rat liver miscrosomal glycerol-3-phosphate acyl transferase
31. Nonenzymatic cleavage of proteins by reactive oxygen species generated by dithiothreitol and iron
32. Alterations of the microsomal glucose-6-P dehydrogenase system evoked by ferrous iron and haloalkane free radical-mediated lipid peroxidation
33. Hemin-mediated oxidative degradation of proteins
34. 2
35. Enzymatic oxidation of α-chymotrypsin
36. Oxidative inactivation of an extramitochondrial acetyl-CoA hydrolase by autooxidation of L-ascorbic acid
37. Site-specific modification of albumin by free radicals. Reaction with copper (II) and ascorbate
38. Hydroperoxide-mediated fragmentation of proteins
39. Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions
40. Alkaline phosphate inactivation by mixed function oxidation systems
41. Mixed function oxidation and enzymes kinetic and structural properties of oxidatively modified alkaline phosphates
42. Increased oxygen radical-dependent inactivation of metabolic enzymes of liver microsomes after chronic ethanol consumption
43. Studies on ascorbic acid. II. Physical changes in catalase following incubation with ascorbate or ascorbate and copper(II)
44. Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen
45. Role of site-specific, metal-catalyzed oxidation in lens-aging and cataract: a hypothesis
46. 2+ oxidation of α-crystallin produces a 43,000 Da aggregate composed of A and B chains cross-linked by nonreducible covalent bonds
47. Oxidative inactivation of yeast fructose-1,6-bisphosphatase
48. Age-related changes in oxidized proteins
49. Oxidation of Neurospora crassa glutamine synthetase
50. Oxidation of Neurospora crassa NADP-specific glutamate dehydrogenase by activated oxygen species
51. The effect of mixed-function oxidation of enzymes on their susceptibility to degradation by a nonlysosomal cysteine protease
52. Decay of hexokinase during reticulocyte maturation: Is oxidative damage a signal for destruction?
53. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: Inactivation of the enzyme
54. Alteration of aminoacyl-tRNA synthetase with age: Heat labilization of the enzyme by oxidative damage
55. Implication of lysine residues in the loss of enzymatic activity in rat liver 6-phosphogluconate dehydrogenase found in aging
56. 1-antiproteinase by hydroxyl radicals
57. Implication of protein oxidation in protein turnover, aging and oxygen toxicity
58. Sequence of a peptide susceptible to mixed-function oxidation: probable cation binding site in glutamine synthetase
59. Derivatization of γ-glutamyl semialdehyde residues in oxidized proteins by fluoresceinamine
60. Hydrogen peroxide mediates the oxidative inactivation of enzymes following switch from anaerobic to aerobic metabolism in Klebsiella aerogenes
61. Novel subunit-subunit interactions in the structure of glutamine synthetase
62. On the cytotoxicity of vitamin C and metal ions. A site-specific Fenton mechanism
63. Manganese(II)-bicarbonate-mediated catalytic activity for hydrogen peroxide dismutation and amino acid oxidation: detection of free radical intermediates
64. Determination of carbonyl content in oxidatively modified proteins
65. Inactivation of enzymes and oxidative modification of proteins by stimulated neutrophils
66. Mixd-function oxidation of histidine residues
67. Determination of carbonyl groups in oxidatively modified proteins by reduction with tritiated sodium borohydride
68. Use of fluorescein hydrazide and fluorescein thiosemicarbazide reagents for the fluorometric determination of protein carbonyl groups and for the detection of oxidized proteins on polyacrylamide gels
69. Specific oxidation of peptides via their copper complexes
70. Nonenzymatic peptide α-amidation. Implication for a novel enzyme mechanism
71. Detection of oxidized amino acid residues using P-amino benzoic acid adducts
72. A mechanism for accelerated degradation of intracellular proteins after limited damage by free radicals
73. Free radicals, lipids and protein degradation
74. Methods for determination of aldehydic lipid peroxidation products
75. Glucose and aging
76. Glucose autooxidaton and protein modification. The potential role of autooxidative glycosylation in diabetes
77. Hydroxyl radical production and autooxidative glycosylation Glucose autooxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing
78. The possible contribution of glucose autooxidation to protein modification of diabetes
79. Aldehydes and dicarbonyl in nonenzymic glycosylation of proteins. A rebuttal to Harding and Beswick
80. Covaneltn modification of proteins by mixed-function oxidation: recognition by intracellular proteases
81. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular proteases
82. Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase: characterization as a high molecular weight cysteine proteinase
83. Purification of a protease from Escherichia coli wih specificity for oxidized glutamine synthetase
84. Protease So from Escherichia coli preferentially degrades oxidatively damaged glutamine synthetase
85. Macroxyproteinase (MOP) A 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells
86. Oxidative modification of the glutamine synthetase of E. coli enhances its susceptibility to proteolysis
87. Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein
88. Degradation of oxidatively denatured proteins in Escherichia coli
89. Mitochondria contain a proteolytic system which can recognize and degrade oxidatively proteins
90. Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells
91. Protein damage and degradation by oxygen radicals. I. General aspects
92. Protein damage and degradation by oxygen radicals. II. Modification of amino acids
93. Fenton chemistry revisited: amino acid oxidation
94. Modulation of the hydrophobicity of glutamine synthetase by mixed-function oxidation
95. Mixed-function oxidation of glutamine synthetase: correlation of chemical and biochemical alterations
96. Proteolysis induced by metal-catalyzed oxidation
97. Metal-catalyzed oxidation of Escherichia coli glutamine synthetase: correlations of structural and functional damage
98. Protein damage and degradation by oxygen radicals. III. modification of secondary and tertiary structure
99. Detection of inactive enzyme molecules in ageing organisms
100. A role of mixed-function oxidation of altered enzyme forms during aging
101. Protein modification in aging
102. Posttranslational modification of enzymes
103. Protein oxidation and proteolysis during aging and oxidative stress
104. The oxidative modification of lens proteins
105. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain
106. Oxidation state of tissue thiol groups and content of protein carbonyl groups in chickens with inherited muscular dystrophy
107. Oxygen radical-induced alterations in polyclonal IgG
108. Increased carbonyl content of proteins in symovial fluid from patients with rheumatoid arthritis
109. A role of endothelial cell lysoxygenase in the oxidative modification of low density lipoprotein
110. Rapid correction of severe hyponatremia results in myelinolysis brain protein oxidation and altered blood chemistries
111. Inactivation of enzymes and oxidative modification of proteins by stimulated neutrophils
112. Effect of reactive oxygen species on myelin membrane proteins