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Tetrahedron Letters
Volumn 31, Issue 52, 1990, Pages 7587-7590
Expeditious synthesis of a key C9-C21 subunit of the aplyslatoxine and oscillatoxins
Author keywords

[No Author keywords available]
Indexed keywords

APLYSIATOXIN; OSCILLATOXIN D; TOXIN; UNCLASSIFIED DRUG;
EID: 0025670150     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)97305-2     Document Type: Article
Times cited : (30)
References (25)
  • 7
    • 84918126968 scopus 로고    scopus 로고
    • Personal communication from professor Richard E. Moore, University of Hawaii. The activity noted was based on an assay using the L1210 cell line.
  • 13
    • 84918126967 scopus 로고    scopus 로고
    • 19 bromines in place (e.g. as part of the aldehyde11) until the end the synthesis. Thus the nonbrominated intermediate11 is truly general.
  • 15
    • 84918126966 scopus 로고    scopus 로고
    • All new compounds exhibited spectroscopic and analytical properties commensurate with their identities and purities. This data will be reported in a forthcoming full account of this research, but until then is available from the authors upon request.
  • 17
    • 0000133961 scopus 로고
    • The diethylboron enolate14 was formed by treating the N-propionyloxazolidinone with diethylboron triflate generated from triethylborane and triflic acid in situ. See
    • (1990) J. Am. Chem. Soc. , vol.112 , pp. 2767
    • Oppolzer1    Blagg2    Rodriguez3    Walther4
  • 19
    • 84918126965 scopus 로고    scopus 로고
    • As an alternative to purifying the major aldol product15, we have found that the crude aldol product could be converted to the diol17 and then purified by crystallization to yield the diastereomerically pure material.
  • 20
    • 84918126964 scopus 로고    scopus 로고
    • 13 to the iodomethyl group resulted in the removal of the MPM group during the reaction of the 13-mesylate with Nal.
  • 25
    • 84918126963 scopus 로고    scopus 로고
    • This research was made possible by funding from the Robert A. Welch Foundation and by donations graciously provided by Lubbock Oncology Associates (David R. Close, M.D.) and Lubbock Oncology Clinic (Benny P. Phillips, M.D., All A. El-Domeiri, M.D.). The NMR spectrometer employed was purchased using funds provided by the NSF (#CHE-851404). The assistance of Dr. Masakazu Hirasawa with the measurement of CD spectra is gratefully acknowledged.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.