Diltiazem and atenolol in essential hypertension: Additivity of effects on blood pressure and cardiac conduction with combination therapy

Journal of Hypertension

Volumn 8, Issue 11, 1990, Pages 1015-1019

  Tonkin, Anne L ^a   Wing, Lindon M H ^a   Russell, Andrew E ^a   West, Malcolm J ^a   Bune, Alexandra J C ^a   Morris, Margaret J ^a   Cain, Michael D ^a   Chalmers, John ^a  

^a REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

Atenolol; Blood pressure; Calcium channel blockers; Cardiac conduction; Diltiazem

Indexed keywords

ATENOLOL; DILTIAZEM;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ESSENTIAL HYPERTENSION; FEMALE; HEART CONDUCTION; HUMAN; HUMAN EXPERIMENT; MALE; ORAL DRUG ADMINISTRATION;

ATENOLOL; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; COMPARATIVE STUDY; DILTIAZEM; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HEART CONDUCTION SYSTEM; HEART RATE; HUMAN; HYPERTENSION; SUPPORT, NON-U.S. GOV'T;

EID: 0025663455     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/00004872-199011000-00007     Document Type: Article

References (29)

1. Halperin AK, Cubeddu LX: The role of calcium channel blockers in the treatment of hypertension. Am Heart J 1986, 111:363-382.
2. Yamakado T, Oonishi N, Kondo S, Noziri A, Nakano T, Takezawa H: Effects of diltiazem on cardiovascular responses during exercise in systemic hypertension and comparison with propranolol. Am J Cardiol 1983, 52:1023-1027.
3. Pool PE, Massie BM, Venkataraman K, et al.: Diltiazem as monotherapy for systemic hypertension: a multicenter, randomized, placebo-controlled trial. Am J Cardiol 1986, 57:212-217.
4. Nikkila MT, Inkovaara JA, Heikkinen JT, Olsson SOR: Antihypertensive effect of diltiazem in a slow-release formulation for mild to moderate essential hypertension. Am J Cardiol 1989, 63:1227-1230.
5. Myburgh DP, Gordon NF: Comparison of diltiazem and atenolol in young, physically active men with essential hypertension. Am J Cardiol 1987, 60:1092-1095.
6. Weir MR, Josselson J, Giard MJ, et al.: Sustained-release diltiazem compared with atenolol monotherapy for mild to moderate systemic hypertension. Am J Cardiol 1987, 60:361-411.
7. Luurila OJ, Grohn P, Heikkila J, et al.: Exercise capacity and hemodynamics in persons aged 20 to 50 years with systemic hypertension treated with diltiazem and atenolol. Am J Cardiol 1987, 60:832-835.
8. Massie B, MacCarthy EP, Ramanathan KB, et al.: Diltiazem and propranolol in mild to moderate essential hypertension as monotherapy or with hydrochlorothiazide. Ann Intern Med 1987, 107:150-157.
9. Oesterle SN, Alderman EL, Beier-Scott L, Baim DS, Rothman MT, Schroeder JS: Diltiazem and propranolol in combination: hemodynamic effects following acute intravenous administration. Am Heart J 1986, 111:489-497.
10. Trimarco B, DeLuca N, Ricciardelli B, et al.: Diltiazem in the treatment of mild or moderate essential hypertension. Comparison with metoprolol in a crossover double-blind trial. J Clin Pharmacol 1984, 24:218-227.
11. Inouye IK, Massie BM, Benowitz N, Simpson P, Loge D: Anti-hypertensive therapy with diltiazem and comparison with hydrochlorothiazide. Am J Cardiol 1984, 53:1588-1592.
12. Leehey DJ, Hartman E: Comparison of diltiazem and hydrochlorothiazide for treatment of patients 60 years of age or older with systemic hypertension. Am J Cardiol 1988, 62:1218-1223.
13. Frishman WH, Zawada ET, Smith LK, et al.: Comparison of hydrochlorothiazide and sustained-release diltiazem for mild-to-moderate systemic hypertension. Am J Cardiol 1987, 59:615-623.
14. Brunner HR, Bidiville J, Waeber G, Porchet M, Nussberger J, Waeber B: Angiotensin-converting enzyme inhibitor versus calcium antagonist in the treatment of hypertension. Nephron 1987, 47 (suppl 1):87-89.
15. Woleson P, Abernethy D, Dipette DJ, Zusman R: Diltiazem and captopril alone or in combination for treatment of mild to moderate systemic hypertension. Am J Cardiol 1988, 62:103G-108G.
16. Schulte K-L, Meyer-Sahellek WA, Haertenberger A, et al.: Antihypertensive and metabolic effects of diltiazem and nifedipine. Hypertension 1986, 8:859-865.
17. Klein W, Brandt D, Vrecko K, Harringer M: Role of calcium antagonists in the treatment of essential hypertension. Circ Res 1983, 52 (suppl 1):174-181.
18. Frishman WH, Charlap S, Goldberger J, et al.: Comparison of diltiazem and nifedipine for both angina pectoris and systemic hypertension, Am J Cardiol 1985, 56: 41H-46H.
19. Wing LMH, Chalmers JP, West MJ, et al.: Enalapril and atenolol in essential hypertension: attenuation of hypotensive effects in combination. Clin Exp Hypertens 1988, 10:119-133.
20. Tsai R-C, Yamaji T, Ishibashi M, et al.: Effect of β-adrener-gic blockade on plasma levels of atrial natriuretic peptide during exercise in humans. J Cardiovasc Pharmacol 1988, 11:614-618.
21. Donckier JE, De Coster PM, Buysschaert M, et al.:. Effect of β-adrenergic blockade on plasma atrial natriuretic factor and cardiac volumes during exercise in normal men. Am J Cardiol 1989, 63:1000-1002.
22. Nakaoka H, Kitihara Y, Amano M, et al.: Effect of β-adren-ergic receptor blockade on atrial natriuretic peptide in essential hypertension. Hypertension 1988, 10:221-225.
23. Armitage P, Berry G: Statistical Methods in Medicai Research 2nd edn. Oxford: Blackwell Scientific Publications, 1987.
24. Morris MJ, Cain M, Russell A, Elliott J, Chalmers J: Direct radioimmunoassay of human plasma atrial natriuretic peptide in various normal and pathophysiological states: increase in renal and cardiac failure and during exercise. Clin Exp Hypertens 1987, A9:703-718.
25. Bulpitt CJ, Dollery CT: Side effects of hypotensive agents evaluated by a self administered questionnaire. Br Med J 1973, 3:485-487.
26. Bulpitt CJ, Dollery CT, Carne S: Change in symptoms of hypertensive patients after referral to hospital clinic. Br Heart J 1976, 28:121-128.
27. Hung J, Lamb IH, Connolly SJ, Jutzy KR, Goris ML, Schroeder JS: The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study. Circulation 1983, 68:560-567.
28. Hassell AB, Creamer JE: Profound bradycardia after the addition of diltiazem to a β-blocker. Br Med J 1989, 298:675.
29. Temkin LP: High-dose monotherapy and combination therapy with calcium channel blocker for angina. A comprehensive review of the literature. Am J Med 1989, 86 (suppl 1A):23-27.