-
1
-
-
0022493495
-
SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman, E. M., Brown, J. M., Lemmon, M. J., Hirst, V. K., and Lee, W. W. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys., 12:1239–1242,1986.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
2
-
-
0023689603
-
Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity
-
Baker, M. A., Zeman, E. M., Hirst, V. K., and Brown, J. M. Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Res., 48:5947–5952, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 5947-5952
-
-
Baker, M.A.1
Zeman, E.M.2
Hirst, V.K.3
Brown, J.M.4
-
3
-
-
0024414046
-
The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay
-
Stratford, I. J., and Stephens, M. A. The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay. Int. J. Radiat. Oncol. Biol. Phys., 16:973–976,1989.
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.16
, pp. 973-976
-
-
Stratford, I.J.1
Stephens, M.A.2
-
4
-
-
0023750547
-
Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233
-
Zeman, E. M., Hirst, V. K., Lemmon, M. J., and Brown, J. M. Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233. Radiother. Oncol., 12:209–218,1988.
-
(1988)
Radiother. Oncol.
, vol.12
, pp. 209-218
-
-
Zeman, E.M.1
Hirst, V.K.2
Lemmon, M.J.3
Brown, J.M.4
-
5
-
-
84958879152
-
Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation
-
Brown, J. M., and Lemmon, M. J. Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation. Int. J. Radiat. Oncol. Biol. Phys., in press, 1990.
-
(1990)
Int. J. Radiat. Oncol. Biol. Phys.
-
-
Brown, J.M.1
Lemmon, M.J.2
-
6
-
-
0000454775
-
Exploitation of bioreductive agents with vasoactive drugs
-
E. M. Fielden, J. F. Fowler, J. H. Hendry, and D. Scott (eds.) London: Taylor and Francis
-
Brown, J. M. Exploitation of bioreductive agents with vasoactive drugs. In: E. M. Fielden, J. F. Fowler, J. H. Hendry, and D. Scott (eds.), Radiation Research, Proceedings of the 8th International Congress of Radiation Research, Vol. 2, pp. 719–724. London: Taylor and Francis, 1987.
-
(1987)
Radiation Research, Proceedings of the 8th International Congress of Radiation Research
, vol.2
, pp. 719-724
-
-
Brown, J.M.1
-
7
-
-
0024421136
-
Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma
-
Sun, J. R., and Brown, J. M. Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. Cancer Res., 49:5664–5670,1989.
-
(1989)
Cancer Res.
, vol.49
, pp. 5664-5670
-
-
Sun, J.R.1
Brown, J.M.2
-
8
-
-
0023929181
-
Molecular mechanisms for the hypoxia-dependent activation of 3-amino-l,2,4-benzotriazine-l,4-dioxide (SR 4233)
-
Laderoute, K., Wardman, P., and Rauth, A. M. Molecular mechanisms for the hypoxia-dependent activation of 3-amino-l,2,4-benzotriazine-l,4-dioxide (SR 4233). Biochem. Pharmacol., 37:1487–1495, 1988.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 1487-1495
-
-
Laderoute, K.1
Wardman, P.2
Rauth, A.M.3
-
9
-
-
0024363523
-
Pre-and post-irradiation radiosensitization by SR 4233
-
Zeman, E. M., and Brown, J. M. Pre-and post-irradiation radiosensitization by SR 4233. Int. J. Radiat. Oncol. Biol. Phys., 16:967–971,1989.
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.16
, pp. 967-971
-
-
Zeman, E.M.1
Brown, J.M.2
-
10
-
-
0018760476
-
Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
-
Brown, J. M. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br. J. Radiol., 52:650–656, 1979.
-
(1979)
Br. J. Radiol.
, vol.52
, pp. 650-656
-
-
Brown, J.M.1
-
11
-
-
0022469972
-
Acute hypoxia in tumors: implications for modifiers of radiation effects
-
Chaplin, D. J., Durand, R. E., and Olive, P. L. Acute hypoxia in tumors: implications for modifiers of radiation effects. Int. J. Radiat. Oncol. Biol. Phys., 12:1279–1282,1986.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1279-1282
-
-
Chaplin, D.J.1
Durand, R.E.2
Olive, P.L.3
-
12
-
-
0025020275
-
Aerobic radiosensitization by SR 4233 in vitro and in vivo
-
Zeman, E. M., Lemmon, M. J., and Brown, J. M. Aerobic radiosensitization by SR 4233 in vitro and in vivo. Int. J. Rad. Oncol. Biol. Phys., 18:125–132, 1990.
-
(1990)
Int. J. Rad. Oncol. Biol. Phys.
, vol.18
, pp. 125-132
-
-
Zeman, E.M.1
Lemmon, M.J.2
Brown, J.M.3
-
13
-
-
84966147249
-
SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes
-
Brown, J. M., and Lemmon, M. J. SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes. Radiother. Oncol., in press, 1990.
-
(1990)
Radiother. Oncol.
-
-
Brown, J.M.1
Lemmon, M.J.2
-
14
-
-
0020505070
-
Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of l-(2-chloroethyl)-3-cyclohexyl-l -nitrosourea
-
Hirst, D. G., Brown, J. M., and Hazlehurst, J. L. Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of l-(2-chloroethyl)-3-cyclohexyl-l -nitrosourea. Cancer Res., 43:1961–1965,1983.
-
(1983)
Cancer Res.
, vol.43
, pp. 1961-1965
-
-
Hirst, D.G.1
Brown, J.M.2
Hazlehurst, J.L.3
-
15
-
-
0015391488
-
Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative
-
Rockwell, S. C., Kallman, R. F., and Fajardo, L. F. Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. J. Natl. Cancer Inst., 49:735–749, 1972.
-
(1972)
J. Natl. Cancer Inst.
, vol.49
, pp. 735-749
-
-
Rockwell, S.C.1
Kallman, R.F.2
Fajardo, L.F.3
-
16
-
-
0018842376
-
A new mouse tumor model system (RIF-1) for comparison of end-point studies
-
Twentyman, P. R., Brown, J. M., Gray, J. W., Franko, A. J., Scoles, M. A., and Kallman, R. F. A new mouse tumor model system (RIF-1) for comparison of end-point studies. J. Natl. Cancer Inst., 64: 595–604,1980.
-
(1980)
J. Natl. Cancer Inst.
, vol.64
, pp. 595-604
-
-
Twentyman, P.R.1
Brown, J.M.2
Gray, J.W.3
Franko, A.J.4
Scoles, M.A.5
Kallman, R.F.6
-
17
-
-
0023688667
-
Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas, (ii) Cell sorting
-
Siemann, D. W., and Keng, P. C. Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas, (ii) Cell sorting. Br. J. Cancer, 58: 296–300, 1988.
-
(1988)
Br. J. Cancer
, vol.58
, pp. 296-300
-
-
Siemann, D.W.1
Keng, P.C.2
-
18
-
-
0021276479
-
Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data
-
Moulder, J. E., and Rockwell, S. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int. J. Radiat. Oncol. Biol. Phys., 10:695–712, 1984.
-
(1984)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.10
, pp. 695-712
-
-
Moulder, J.E.1
Rockwell, S.2
-
19
-
-
0018895629
-
Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages
-
Brown, J. M., Twentyman, P. R., and Zamvil, S. S. Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages. J. Natl. Cancer Inst., 64:605–611, 1980.
-
(1980)
J. Natl. Cancer Inst.
, vol.64
, pp. 605-611
-
-
Brown, J.M.1
Twentyman, P.R.2
Zamvil, S.S.3
-
20
-
-
0024324987
-
Hypoxic cell radiosensitizers: where next?
-
Brown, J. M. Hypoxic cell radiosensitizers: where next? Int. J. Radiat. Oncol. Biol. Phys., 16:987–993, 1989.
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.16
, pp. 987-993
-
-
Brown, J.M.1
-
21
-
-
0022471797
-
Sensitizers and radiation dose fractionation: results and interpretations
-
Hill, R. P. Sensitizers and radiation dose fractionation: results and interpretations. Int. J. Radiat. Oncol. Biol. Phys., 12:1049–1054,1986.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1049-1054
-
-
Hill, R.P.1
-
22
-
-
0021184329
-
Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report
-
Brown, J. M., and Yu, N. Y. Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report. Int. J. Radiat. Oncol. Biol. Phys., 10:1207–1212, 1984.
-
(1984)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.10
, pp. 1207-1212
-
-
Brown, J.M.1
Yu, N.Y.2
-
23
-
-
0026417645
-
The therapeutic advantage of hypoxic cells in tumors: A theoretical study
-
Brown, J. M., and Koong, A. The therapeutic advantage of hypoxic cells in tumors: A theoretical study. J. Natl. Cancer Inst., in press, 1990.
-
(1990)
J. Natl. Cancer Inst.
-
-
Brown, J.M.1
Koong, A.2
|