Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

Neuron

Volumn 5, Issue 6, 1990, Pages 767-771

  MacKinnon, Roderick ^a   Heginbotham, Lise ^a   Abramson, Tatiana ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARYBDOTOXIN; COMPLEMENTARY DNA; POTASSIUM CHANNEL;

ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE EXPRESSION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; CHARYBDOTOXIN; CLONING, MOLECULAR; ELECTROPHYSIOLOGY; FEMALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POTASSIUM CHANNELS; PROTEIN CONFORMATION; SCORPION VENOMS; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; XENOPUS;

EID: 0025644364     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(90)90335-D     Document Type: Article

References (26)

1. + channels: effects of channel gating, voltage, and ionic strength
2. Inactivation of the sodium channel: 1. Sodium current experiments
3. Structure and function of voltage-sensitive ion channels
4. A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning
5. Purification and characterization of a unique, potent, peptidylprobe for the high-conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus
6. + channels
7. Models of voltage- and transmitter-activated membrane channels based on their amino acid sequences
8. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity
9. Rapid and efficient site-specific mutagenesis without phenotypic selection
10. + channels
11. + channel
12. + channel by trimethyloxonium
13. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor
14. + channels
15. + channels sharecommon structural features
16. The role of surface electrostatics in the operation of a high-conductance Ca-activated K channel
17. Molecular structure of charybdotoxin, a pore-directed inhibitor of potassium ion channels
18. Electrostatic potentials at membranesolution interfaces
19. + channel by charybdotoxin and tetraethylammonium
20. + channels from mammalian skeletal muscle
21. An emerging pharmacology of peptide toxins targeted against potassium channels
22. A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II
23. DNA sequencing with chain-terminating inhibitors
24. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain
25. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila