Pharmacological profile of RWJ 20085: A new, potent, long‐acting local anesthetic

Drug Development Research

Volumn 21, Issue 4, 1990, Pages 277-289

  Dubinsky, Barry ^a   Shriver, David A ^a   Sanfilippo, Pauline J ^a   Press, Jeffery B ^a   Tobia, Alfonso J ^a   Rosenthale, Marvin E ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

cornea; frog sciatic nerve; guinea pig; intradermal; mouse; perineural infiltration; rabbit; topical

Indexed keywords

2 [4 (3 DIBUTYLAMINOPROPOXY)PHENYL] 8 METHYLIMIDAZO[1,2 A]PYRIDINE; BUPIVACAINE; ETIDOCAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; RWJ 20085; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORNEA; FROG; GUINEA PIG; INTRAARTERIAL DRUG ADMINISTRATION; INTRADERMAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LOCAL ANESTHESIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCIATIC NERVE; TOPICAL DRUG ADMINISTRATION;

EID: 0025643559     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.430210403     Document Type: Article

References (23)

1. Local anesthetic activity and acute toxicity of (±)‐2‐(N‐ethylpropylamino)‐2′,6′‐butyroxylidide, a new long‐acting agent
2. Some pharmacological properties of o‐methyl‐alpha‐propylaminopropionanilide, a new local anesthetic
3. Structure‐activity relationship of lidocaine homologs producing tonic and frequency‐dependent impulse blockade in nerve
4. Delayed contact hypersensitivity in the guinea pig
5. Biological comparison of local anesthetics
6. Clinical trial of xylocaine in local anesthesia
7. Comparative clinical pharmacology of local anesthetic agents
8. Toxicity and systemic effects of local anesthetic agents
9. Dermal toxicity. In Staff of the Division of Pharmacology, Food and Drug Administration U. S. Department of Health Education and Welfare (eds.)
10. Experimental epidural anesthesia in the cat with lignocaine and amethocaine
11. Clinical experiences with mepivacaine (Carbocaine)
12. The use of xylocaine, a new local anesthetic, in surgery, obstetrics and therapeutics
13. Some pharmacological and toxicological properties of a new long‐acting local analgesic. LAC‐43 (MARCAINE), in comparison with mepivacaine and tetracaine
14. Role of protein synthesis in recovery from local anesthetic‐induced conduction blockade
15. A statistical evaluation of the relationships among local anesthetic activity, irritancy and systemic toxicity
16. Bupivacaine. A review of 2,077 cases
17. Synthesis of aryloxyalkylamines. II. Novel imidazo‐fused heterocycles with calcium channel blocking and local anesthetic activity
18. Comparative study of local anesthetics. IV. Anesthesia of rabbit's cornea
19. The duration of action of bupivacaine, prilocaine and lignocaine
20. Studies on the pharmacology of meprylcaine (ORACAINE), a local anesthetic
21. Differential physical‐chemical and neuropharmacologic properties of local anesthetic agents