Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat

European Journal of Pharmacology

Volumn 191, Issue 3, 1990, Pages 485-488

  Boughton Smith, Nigel K ^a   Hutcheson, Iain R ^a   Deakin, Angela M ^a   Whittle, Brendan J R ^a   Moncada, S ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

Endotoxin; NG Monomethyl L arginine (L NMMA); Nitric oxide; Nitro vasodilators; NO; Vascular injury

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; N ACETYL S NITROSOPENICILLAMINE; N(G) METHYLARGININE; NITRIC OXIDE; VASODILATOR AGENT;

ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL; CONTROLLED STUDY; INTESTINE INJURY; INTRAVENOUS DRUG ADMINISTRATION; JEJUNUM; MALE; NONHUMAN; PLASMA EXTRAVASATION; PRIORITY JOURNAL; PROTECTION; RAT;

ANIMAL; ARGININE; BLOOD PRESSURE; ENDOTOXINS; ESCHERICHIA COLI; INTESTINAL DISEASES; JEJUNUM; LIPOPOLYSACCHARIDES; MALE; OMEGA-N-METHYLARGININE; PENICILLAMINE; RATS; RATS, INBRED STRAINS; S-NITROSO-N-ACETYLPENICILLAMINE; SERUM ALBUMIN, RADIO-IODINATED; VASODILATOR AGENTS;

EID: 0025614347     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(90)94185-Z     Document Type: Article

References (10)

1. Beneficial effects of two forms of NO administration in feline splanchnic artery occlusion
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3. Endotoxin-induced intestinal damage in the rat is enhanced by L-NMMA an inhibitor of nitric oxide formation
4. Mechanisms of vascular smooth muscle relaxation by organic nitrates, nitrates, nitroprusside and nitric oxide. Evidence for the involvement of s-nitrosothiols as active ingredients
5. Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion
6. Inhibition of FMLP-induced aggregation of rabbit neutrophils by nitric oxide
7. Biosynthesis of nitric oxide from L-arginine. A pathway far regulation of cell function and communication
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10. Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation