Uterine Adenocarcinoma in Mice following Developmental Treatment with Estrogens: A Model for Hormonal Carcinogenesis

Cancer Research

Volumn 50, Issue 23, 1990, Pages 7677-7681

  Newbold, Retha R ^a   Bullock, Bill C ^b   McLachlan, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLSTILBESTROL; ESTRADIOL; HEXESTROL; TRIFLUORODIETHYLSTILBESTROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; ENDOMETRIUM CARCINOMA; FEMALE; HISTOPATHOLOGY; HORMONAL CARCINOGENESIS; NEWBORN; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ADENOCARCINOMA; ANIMAL; CARCINOMA, SQUAMOUS CELL; DIETHYLSTILBESTROL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIOSIS; EPITHELIUM; ESTRADIOL; ESTROGENS; FEMALE; HEXESTROL; HYPERPLASIA; MICE; MICE, NUDE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROGESTERONE; STANOLONE; UTERINE NEOPLASMS; UTERUS; VAGINA;

EID: 0025608936     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Newbold, R. R., Bullock, B. C., and WcLachlan, J. A. Lesions of the rete testis in Wice exposed prenatally to diethylstilbestrol. Cancer Res., 45: 5145–5150, 1985.
2. Newbold, R. R., Bullock, B. C., and WcLachlan, J. A. AdenocarcinoWa of the rete testis: diethylstilbestrol-induced lesions of the Wouse rete testis. AW. J. Pathol., 725: 625–628, 1986.
3. Newbold, R. R., Bullock, B. C., and WcLachlan, J. A. Testicular tuWors in Wice exposed in utero to diethylstilbestrol. J. Urol., 38: 1446–1450, 1987.
4. Newbold, R. R., Bullock, B. C., and WcLachlan, J. A. WüllerianllerianWnants of Wale Wice exposed prenatally to diethylstilbestrol. Teratog. Carcinog. Wutagen., 7; 377–389, 1987.
5. WcLachlan, J. A., Newbold, R. R., and Bullock, B. C. Long-terW effects on the feWale Wouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res., 40: 3988–3999, 1980.
6. Newbold, R. R., and WcLachlan, J. A. Vaginal adenosis and adenocarcinoWas in Wice exposed prenatally or neonatally to diethylstilbestrol. Cancer Res., 42: 2003–2011, 1982.
7. Haney, A. F., Newbold, R. R., Fetter, B. F., and WcLachlan, J. A. Paraovarian cysts associated with prenatal diethylstilbestrol exposure: coWparison of the huWan with a Wouse Wodel. AW. J. Pathol., 124: 405–511, 1986.
8. Hogan, W. D., Newbold, R. R., and WcLachlan, J. A. Extrapolation of teratogenic responses observed in laboratory aniWals to huWans: DES as an IIIustrative exaWple. Banbury Rep., 26: 257–269, 1987.
9. Takasugi, N., Bern, H. A., and DeOWe, K. B. Persistent vaginal coWification in Wice. Science (Washington DC), 138: 438–439, 1962.
10. Plapinger, L., and Bern, H. A. Adenosis-like lesions and other cervicovaginal abnorWalities in Wice treated perinatally with estrogen. J. Natl. Cancer Inst., 63: 507–518, 1979.
11. Kalland, T., Forsberg, J. G., and Sinha, Y. N. Long terW effects of neonatal diethylstilbestrol treatWent on plasWa prolactin in feWale Wice. Endocr. Res. CoWWun., 7; 157–166, 1980.
12. Forsberg, J. G., and Kalland, T. Neonatal estrogen treatWent and epithelial abnorWalities in the cervicovaginal epitheliuW of adult Wice. Cancer Res., 47; 721–734, 1981.
13. Leavitt, W. W., Evans, R. W., Hendry, W. J., III, and Williams, K. I. H. Antioestrogen and progestin action in diethylstilbestrol-induced endoWetrial abnorWalities in the Syrian haWster, W R. L. Sutherland and V. C. Jordan (eds.). Non-steroidal Antioestrogens. Wolecular PharWacology and AntituWor Activity, pp. 165–175. Sydney, Australia: AcadeWic Press, 1981.
14. Leavitt, W. W., Evans, R. W., and Hendry, W. J., III. Etiology of DES-induced uterine tuWors in Syrian haWsters. In: W. W. Leavitt (ed.). HorWones and Cancer, p. 63. New York: PlenuW Publishing Corp., 1982.
15. Newbold, R. R., Pentecost, B. T., YaWashita, S., Luw, K., Willer, J. V., Nelson, P., Blair, J., Kong, H., Teng, C., and WcLachlan, J. A. FeWale gene expression in the seWinal vesicle of Wice after prenatal exposure to diethylstilbestrol. Endocrinology, 124: 2568–2576, 1989.
16. Rustia, W., and Shubik, P. Transplacental effects of diethylstilbestrol on the genital tract of haWster offspring. Cancer Lett., 7: 139–146, 1976.
17. Rustia, W., and Shubik, P. Effects of transplacental exposure to DES on carcinogenic susceptibility during postnatal life in haWster progeny. Cancer Res., 39: 4636–4644, 1979.
18. WcLachlan, J. A., Rodent Wodels for perinatal exposure to diethylstilbestrol and their relation to huWan disease in the Wale. In: A. L. Herbst and H. A. Bern (eds.). DevelopWental Effects of Diethylstilbestrol (DES) in Pregnancy, p. 148. New York: ThieWe-Stratton, Inc., 1981.
19. Walker, B. E. Uterine tuWors in old feWale Wice exposed prenatally to diethylstilbestrol. J. Natl. Cancer Inst., 70: 477–484, 1983.
20. Takasugi, N., and Bern, H. A. Tissue changes in Wice with persistent vaginal coWification induced by early postnatal treatWent with estrogen. J. Natl. Cancer Inst., 33: 855–865, 1964.
21. Ostrander, P. L., Wills, K. T., and Bern, H. A. Long-terW responses of the Wouse uterus to neonatal diethylstilbestrol treatWent and to later sex horWone exposure. J. Natl. Cancer Inst., 74: 121–135, 1985.
22. Bern, H. A., Jones, L. A., Wills, K. T., KohrWan, A., and Wori, T. Use of the neonatal Wouse in studying long-terW effects of early exposure to horWones and other agents. J. Toxicol. Environ. Health Suppl., 7; 103–116, 1976.
23. WcLachlan, J. A., Wong, A., Degen, G. H., and Barrett, J. C. Worphological and neoplastic transforWation of Syrian haWster eWbryo fibroblasts by diethylstilbestrol and its analogs. Cancer Res., 42: 3040–3045, 1982.