Relationship between Secreted Urokinase Plasminogen Activator Activity and Metastatic Potential in Murine B16 Cells Transfected with Human Urokinase Sense and Antisense Genes

Cancer Research

Volumn 50, Issue 23, 1990, Pages 7623-7633

  Yu, Heron ^a,b   Schultz, Richard M ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UROKINASE;

ANIMAL CELL; ARTICLE; GENETIC TRANSFECTION; HYBRIDIZATION; MELANOMA B16; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CELL MOVEMENT; CELLS, CULTURED; CHROMATOGRAPHY, AFFINITY; DNA, ANTISENSE; FIBRINOLYTIC AGENTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; IN VITRO; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; PLASMIDS; PLASMINOGEN ACTIVATORS; RNA; SIMIAN VIRUS 40; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; URINARY PLASMINOGEN ACTIVATOR;

EID: 0025606452     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Daño, K., Andreasen, P. A., Grondahl-Hansen, J., Kristensen, P., Nielsen, L. S., and Sknver, L. Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res., 44: 139–266, 1985.
2. Goldfarb, R. H., and Liotta, L. A. Proteolytic enzymes in cancer invasion and metastasis, min. Thromb. Hemostasis, 12: 294–307, 1986.
3. Liotta, L. A., Goldfarb, R. H., Brundage, R., Siegal, G. P., Terranova, V., and Garbisa, S. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res., 41: 4629–4636, 1981.
4. Kramer, R. H., Vogel, K. G., and Nicolson, G. L. Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells. J. Biol. Chem., 257: 2678–2686, 1982.
5. Mochan, E., and Keler, T. Plasmin degradation of cartilage proteoglycan. Biochim. Biophys. Acta, 800: 312–315, 1984.
6. Werb, Z., Mainardi, C. L., Vater, C. A., and Harris, E. D. Endogenous activation of latent collagenase of rheumatoid synovial cells: evidence for the role of plasminogen activator. N. Engl. J. Med., 296: 1017–1023, 1977.
7. Paranjpe, M., Engel, L., Young, N., and Liotta, L. A. Activation of human breast carcinoma collagenase through plasminogen activator. Life Sci., 26: 1223–1231, 1980.
8. Gross, J. L., Moscatelli, D., Jaffe, E. A., and Rifkin, D. B. Plasminogen activator and collagenase production by cultured capillary endothelial cells. J. Cell Biol., 95: 974–981, 1982.
9. Schultz, R. M., Silberman, S., Persky, B., Bajkowski, A. S., and Carmichael, D. F. Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res., 48: 5539–5545, 1988.
10. Sullivan, L. M., and Quigley, J. P. An anticatalytic monoclonal antibody to avian plasminogen activator its effect on the behavior of RSV-transformed chick fibroblasts. Cell, 45: 905–915, 1986.
11. Pereyra-Alfonso, S., Haedo, A., and Bal deKier, J. E. Correlation between urokinase type plasminogen activator production and the metastasizing ability of two murine mammary adenocarcinomas. Int. J. Cancer, 42: 59–63, 1988.
12. Duffy, M. J., O'Grady, P., Devaney, D., O'Siorain, L., Fennelly, J. J., and Lijnen, H. J. Urokinase plasminogen activator, a marker for aggressive breast carcinomas; preliminary report. Cancer (Phila.), 62: 531–533, 1988.
13. Harvey, S. R., Lawrence, D. D., Madeja, J. M., Abbey, S. J., and Markus, G. Secretion of plasminogen activators by human colorectal and gastric tumor expiants. Clin. Exp. Metastasis, 6: 431–450, 1988.
14. Sappino, A. P., Busso, N., Belin, D., and Vassalli, J. D. Increase of urokinasetype plasminogen activator gene expression in human lung and breast carcinomas. Cancer Res., 47: 4043–4046, 1987.
15. Degen, J. L., Estensen, R. D., Nagamine, Y., and Reich, E. Induction and desensitization of plasminogen activator gene expression by tumor promoters. J. Biol. Chem., 260: 12426–12433, 1985.
16. Stoppelli, M. P., Verde, P., Grimaldi, G., Locatelli, E. K., and Blasi, F. Increase in urokinase plasminogen activator mRNA synthesis in human carcinoma cells is a primary effect of the potent tumor promoter, phorbol myristate acetate. J. Cell Biol., 102: 1235–1241, 1986.
17. Giraldi, T., Sava, G., Perissin, L., and Zorzet, S. Proteinases and proteinase inhibition by cytotoxic and antimetastatic drugs in transplantable solid metastasizing tumors in mice. Anticancer Res., 5: 355–359, 1985.
18. Camiolo, S. M., Markus, G., and Piver, M. S. Plasminogen activator content of gynecological tumors and their m�tastas�s. Gynecol. Oncol., 26: 364–373, 1987.
19. Recklies, A. D., Tiltman, K. J., Stoker, T., and Poole, A. R. Secretion of proteinases from malignant and nonmalignant human breast tissue. Cancer Res., 40: 550–556, 1980.
20. Zucker, S. Critical appraisal of the role of proteolytic enzymes in cancer invasion: emphasis on tumor surface proteinases. Cancer Invest., 6: 219–231, 1988.
21. Nielsen, L. S., Kellerman, G. M., Behrendt, N., Picone, R., Dano, K., and Blasi, F. A 55,000–60,000 M., receptor protein for urokinase type plasminogen activator: identification in human tumor cell lines and partial purification. J. Biol. Chem., 263: 2358–2363, 1988.
22. Stoppelli, M. P., Corti, A., Soffientini, A., Cassani, G., Blasi, F., and Assoian, R. K. Differentiation-enhanced binding of the amino terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. Proc. Natl. Acad. Sci. USA, 82: 4939–4943, 1985.
23. Boyd, D., Florent, G., Kim, P., and Brattain, M. Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines. Cancer Res., 4: 3112–3116, 1988.
24. Needham, G. K., Sherbet, G. V., Famdon, J. R., and Harris, A. L. Binding of urokinase to specific receptor sites on human breast cancer membranes. Br. J. Cancer, 55: 13–16, 1987.
25. Axelrod, J. H., Reich, R., and Miskin, R. Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ro5-transformed NIH 3T3 cells. Mol. Cell. Biol., 9: 2133–2141, 1989.
26. Fidler, I. J. Biological behavior of malignant melanoma cells correlated with their survival in vivo. Cancer Res., 35: 218–224, 1975.
27. Hanahan, D. Studies on transformation of Escherichia coii with plasmids. J. Mol. Biol., 166: 557–580, 1983.
28. Maniatis, T., Fritsch, E. F., and Sambrook, J. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 88–94, 1982.
29. Graham, F. L., and van der Eb, A. J. Transformation of rat cells by DNA of human adenoviruses. Virology, 54: 536–539, 1973.
30. McCracken, A., and Brown, J. L. A filter immunoassay for detection of protein secreting cell colonies. Biotechniques, 2: 82–87, 1984.
31. Kozlowski, J. M., Fidler, I. J., Campbell, D., Xu, Z. L., Kaighn, M. E., and Hart, I. R. Metastatic behavior of human tumor cell lines grown in the nude mouse. Cancer Res., 44: 3522–3529, 1984.
32. Stoppelli, M. P., Tacchetti, C., Culwllis, M. V., Corti, A., Hearing, V. J., Cassani, G., Appella, E., and Blasi, F. Autocrine saturation of prourokinase receptors on human A431 cells. Cell, 45: 675–684, 1986.
33. Strickland, S., and Beers, W. H. Studies on the role of plasminogen activator in ovulation. In vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins. J. Biol. Chem., 251: 5694–5702, 1976.
34. Whur, P., Magudia, M., Boston, J., Lockwood, J., and Williams, D. C. Plasminogen activator in cultured Lewis lung carcinoma cells measured by chromogenic substrate assay. Br. J. Cancer, 42: 305–313, 1980.
35. Davis, L. G., Dibner, M. D., and Battey, J. F. Basic Methods in Molecular Biology. New York: Elsevier Science Publishing Co., 44–46, 1986.
36. Fidler, I. J. General considerations for studies of experimental cancer metastasis. Methods Cancer Res., 75; 399–439, 1978.
37. Fidler, I. J. Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis Rev., 5: 29–49, 1986.
38. Ossowski, L. Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo. Cell, 52: 321–328, 1988.
39. Huarte, J., Belin, D., Bosco, D., Sappino, A-P., and Vassalli, J-D. Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface. J. Cell Biol., 104: 1281–1289, 1987.
40. Estreicher, A., Wohlwend, A., Belin, D., Schleuning, W. D., and Vassalli, J. D. Characterization of the cellular binding site for the urokinase type plasminogen activator. J. Biol. Chem., 264: 1180–1189, 1989.
41. Holmes, W. E., Pennica, D., Blaber, M., Rey, M. W., Guenzler, W. A., Steffens, G. J., and Heyneker, H. L. Cloning and expression of the gene for prourokinase in Escherichia coii. Biotechnology, 3: 923–929, 1985.
42. Belin, D., Vassalli, J., Combepine, C., Godeau, F., Nagamine, Y., Reich, E., Kocher, H. P., and Duvoisin, R. M. Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase type plasminogen activator. Eur. J. Biochem., 148: 225–232, 1985.
43. Narasimhan, S., Wilson, J. R., Martin, E., and Schächter, H. A structural basis for four distinct elution profiles on concanavalin A-Sepharose aBinity chromatography of glycopeptides. Can. J. Biochem., 57: 83–96, 1979.
44. Ostrowski, L. E., Ahsan, A., Suthar, B. P., Pagast, P., Bain, D. L., Wong, C., Patel, A., and Schultz, R. M. Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis. Cancer Res., 46: 4121–4128, 1986.
45. Hearing, V. J., Law, L. W., Corti, A., Appella, E., and Blasi, F. Modulation of metastatic potential by cell surface urokinase of murine melanoma cells. Cancer Res., 48: 1270–1278, 1988.
46. Kirchheimer, J. C., Christ, G., and Binder, B. R. Growth stimulation of human epidermal cells by urokinase is restricted to the intact active enzyme. Eur. J. Biochem., 181: 103–107, 1989.
47. Kirchheimer, J. C., Wojta, J., Christ, G., and Binder, B. R. Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line. Proc. Natl. Acad. Sci. USA, 86: 5424–5428, 1989.
48. Pollanen, J., Saksela, O., Salonen, E. M., Andreasen, P., Nielsen, L., Dano, K., and Vaheri, A. Distinct localizations of urokinase-type plasminogen activator and its type I inhibitor under cultured human fibroblasts and sarcoma cells. J. Cell Biol., 104: 1085–1096, 1987.
49. Herd, Z. L. Suppression of B16 melanoma lung colonization by syngeneic monoclonal antibodies. Cancer Res., 47: 2696–2703, 1987.
50. Schroeder, F., and Gardiner, J. M. Membrane lipids and enzymes of cultured high and low metastatic B16 melanoma variants. Cancer Res., 44: 3262–3269, 1984.
51. Sadano, H., Taniguchi, S., Kakunaga, T., and Baba, T. cDNA cloning and sequence of a new type of actin in mouse B16 melanoma. J. Biol. Chem., 263: 15868–15871, 1988.
52. Wang, B. S., McLoughlin, G. A., Richie, J. P., and Mannick, J. A. Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines. Cancer Res., 40: 288–292, 1980.
53. Markus, G., Camiolo, S. M., Kohga, S., Madega, J. M., and Mittelman, A. Plasminogen activator secretion of human tumors in short-term organ culture: comparison of primary and metastatic colon tumors. Cancer Res., 43: 5517–5525, 1983.
54. Markus, G. The role of hemostasis and f�brinolysis in the metastatic spread of cancer. Semin. Thromb. Hemostasis, 10: 61–70, 1984.
55. Gunji, Y., and Gorelik, E. Role of fibrin coagulation in protection of murine tumor cells from destruction by cytotoxic cells. Cancer Res., 48: 5216–5221, 1988.
56. Iwakawa, A., Gasic, T. B., Viner, E. D., and Gasic, G. J. Promotion of lung tumor colonization in mice by the synthetic thrombin inhibitor (No. 805) and its reversal by leech salivary gland extracts. Clin. Exp. Metastasis, 4: 205–220, 1986.