Aneuploidy in drosophila. III: Aneuploidogens inhibit in vitro assembly of taxol‐purified drosophila microtubules

Environmental and Molecular Mutagenesis

Volumn 16, Issue 4, 1990, Pages 217-224

  Sehgal, A ^a   Osgood, C ^a   Zimmering, S ^b   Aaron, C S ^a  

^a OLD DOMINION UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Drosophila melanogaster; microtubule assembly; sex chromosome aneuploidy

Indexed keywords

ACETONITRILE; CALCIUM CHLORIDE; COLCHICINE; DIMETHYL SULFOXIDE; PACLITAXEL; PROPIONITRILE;

ANEUPLOIDY; ANIMAL TISSUE; ARTICLE; BRAIN; DROSOPHILA; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETATES; ACETONITRILES; ACRYLONITRILE; ALKALOIDS; ANEUPLOIDY; ANIMAL; CADMIUM; CADMIUM CHLORIDE; COLCHICINE; DIMETHYL SULFOXIDE; DROSOPHILA MELANOGASTER; GRISEOFULVIN; MICE; MICROSCOPY, ELECTRON; MICROTUBULES; NITRILES; PACLITAXEL; SPECTRUM ANALYSIS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0025606063     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.2850160402     Document Type: Article

References (37)

1. Mutagenicity of methyl 2‐benzimidazolecarbamate, diethylstilbesterol, and estradiol: Structural chromosomal aberrations, sister‐chromatid exchanges, C‐mitoses, polyploidies and micronuclei
2. Mechanisms of aneuploidy induction
3. Purification of tubulin and associated proteins from porcine brain and characterization of microtubule assembly in vitro
4. A rapid and sensitive method for quantitation of microgram quantities of proteins utilizes the principle of dye binding
5. Temperature‐dependent reversible assembly of taxol‐treated microtubules
6. Interspecies comparison of carcinogenic potency
7. Griseofulvin
8. Genetic and related effects of Vinca rosea alkaloids
9. The biochemistry of mutagenesis
10. Trisomy after colchicine therapy
11. Molecular mechanisms of mutations
12. Turbidometric studies of in vitro assembly and disassembly of porcine neurotubules
13. Aprotic solvents inducing chromosomal malsegregation in yeast interfere with the assembly of porcine brain tubulin in vitro
14. Diethylstilbestrol induces metaphase arrest and inhibits microtubule assembly
15. Taxol: Mechanism of action and resistance
16. Chromosome mutations: Frequency at birth in humans
17. Population surveillance: A cytogenetic approach
18. Identification of distinctive classes of vinblastin binding sites on microtubules
19. Taxol‐induced polymerization of purified tubulin. Mechanism of action
20. Cleavage of structural proteins during assembly of the head of bacteriophage T4
21. Polyaerylamide gel electrophoresis across a molecular gel sieve gradient
22. Taxol binds to polymerized tubulin in vitro
23. Genetics of microtubule systems
24. Genetk‐effects of organic mercury compounds, II. Chromosome segregation in Drosophila melanogaster
25. A comparative study of the interaction of chlorpromazine, trifluoroperazine and promethazine on mouse brain tubulin
26. Diethylstilbesterol: The binding and effects of diethylstilbestrol upon polymerization and depolymerization of purified microtubule protein in vitro
27. A taxol dependent procedure for the isolation of microtubules and microtubule associated proteins
28. Purification of microtubules and microtubule‐associated proteins from sea urchin eggs and cultured mammalian cells using taxol, and use of exogenous taxol‐stabilized brain microtubules for purifying microtubule‐associated proteins
29. Studies of the interaction of chemicals with microtubule assembly in vitro can be used as an assay for detection of cytotoxic chemicals and possible inducers of aneuoploidy
30. Acetone, methyl ethyl ketone, ethyl acetate, acetonitrile and other polar aprotic solvents are strong inducers of aneuploidy in Saccharomyces cerevisiae