What determines the specificity of action of Drosophila homeodomain proteins?

Cell

Volumn 63, Issue 5, 1990, Pages 883-894

  Hayashi, Shigeo ^a   Scott, Matthew P ^b  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

DNA BINDING; DROSOPHILA; HOMEOBOX; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION; GENES, HOMEOBOX; PROMOTER REGIONS (GENETICS); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC;

EID: 0025602459     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(90)90492-W     Document Type: Review

References (102)

1. DNA binding properties of the purified Antennapedia homeodomain
2. Recognition of a DNA operator by the repressor of the phage 434: a view at high resolution
3. Hox and HOM: Homologous gene clusters in insects and vertebrates
4. A threonine to alanine exchange at position 40 of Tet repressor alters the recognition of the sixth base pair of tet operator from GC to AT
5. An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters
6. Domain of Ultrabithorax expression in Drosophila visceral mesoderm from autoregulation and exclusion
7. A purified Drosophila homeodomain protein represses transcription in vitro
8. 1H nuclear magnetic resonance spectroscopy
9. The localization and regulation of Antennapedia protein expression in Drosophila embryos
10. Developmental analysis of a hybrid gene composed of parts of the Ubx and abd-A genes of Drosophila
11. Ectopic expression from the Deformed gene triggers a dominant defect in Drosophila adult head development
12. The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis
13. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity
14. The sequence specificity of homeodomain-DNA interaction
15. The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner
16. A gradient of bicoid protein in Drosophila embryos
17. The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
18. Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences
19. Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
20. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
21. The bithorax complex
22. Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli
23. The Drosophila fushi tarazu polypeptide is a DNA-binding transcriptional activator in yeast cells
24. Homeotic and atavic mutations in insects
25. Association of the Drosophila melanogaster engrailed protein with specific soluble nuclear protein complexes
26. Homeo boxes in the study of development
27. The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
28. The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products
29. Are cross-regulatory interactions between homoeotic genes functionally significant?
30. Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene
31. The murine and Drosophila homeobox gene complexes have common features of organization and expression
32. Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila
33. Synergistic activation and repression of transcription by Drosophila homeobox proteins
34. DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9
35. Divergent homeo box proteins recognize similar DNA sequences in Drosophila
36. DNA-binding activities of the Drosophila melanogaster even skipped protein are mediated by its homeo domain and influenced by protein context
37. Induction across germ layers in Drosophila mediated by a genetic cascade
38. Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression
39. The yeast transcription activator PRTF, a homolog of the mammalian serum response factor, is encoded by the MCM1 gene
40. Activation and repression of transcription by homoeodomain-containing proteins that bind a common site
41. Stimulation of transcription by an Ultrabithorax protein in vitro
42. Structure of the lambda complex at 2.5 Å resolution: details of the repressor-operator interactions
43. Cytogenetic analysis of chromosome 3 in Drosophila melanogaster: isolation and characterization of four new alleles of the proboscipedia (pb) locus
44. Cytogenetic analysis of chromosome 3 in Drosophila melanogaster: the homeotic gene complex in polytene chromosomal interval 84A, B
45. The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein
46. Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila
47. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions
48. Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells
49. Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos
50. Autoregulation of a Drosophila homeotic selector gene
51. A homeodomain substitution changes the regulatory specificity of the Deformed protein in Drosophila embryo
52. Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins
53. The interaction of proteins encoded by Drosophila homeotic and segmentation genes with specific DNA sequences
54. The interaction of the recognition helix of lac repressor with lac operator
55. Homoebox proteins as sequence-specific transcription factors
56. Genes and developmental pathways
57. A gene complex controlling segmentation in Drosophila
58. A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
59. The homeotic genes of the Antennapedia complex and the bithorax complex of Drosophila
60. Mouse Hox 22 specifies thoracic segmental identity in Drosophila embryos and larvae
61. Functional dissection of Ultrabithorax proteins in D. melanogaster
62. Parasegments and compartments in the Drosophila embryo
63. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans
64. A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes
65. Human Hox-4.2 and Drosophila Deformed encode similar regulatory specificities in Drosophila embryos and larvae
66. Effects of ectopic expression of caudal during Drosophila development
67. Isolation and sequence-specific DNA binding of the Antennapedia homeodomain
68. Coordinate action of a proximal homeoprotein binding site and a distal sequence confers the Ultrabithorax expression pattern in the visceral mesoderm
69. The DNA binding specificity of the Drosophila fushi tarazu protein: a possible role for DAN bending in homeodomain recognition
70. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
71. Binding site-dependent direct activation and repression of in vitro transcription by Drosophila homeodomain proteins
72. Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding transcription factor IID
73. Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif
74. Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution
75. Protein-DNA recognition
76. A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis
77. A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes
78. The interaction with DNA of wild-type and mutant fushi tarazu homeodomains
79. The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with procaryotic repressors
80. Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development
81. Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
82. The structure and expression of a hybrid homeotic gene
83. Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough
84. Gene activation and DNA binding by Drosophila Ultrabithorax and abdominal A proteins
85. Differential regulation of the two transcripts from the Drosophila gap segmentation gene hunchback
86. The b alleles of U. maydis, whose combinations program pathogenic development, code for polypeptides containing a homeodomain-related motif
87. Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila
88. The structure and function of the homeodomain
89. Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA
90. Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins
91. The Oct-1 homeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16
92. Near-reciprocal phenotypes caused by inactivation or indiscriminate expression of the Drosophila segmentation gene ftz
93. The gradient morphogen bicoid is a concentration-dependent transcriptional activator
94. DNA binding-induced conformational change of the yeast transcriptional activator PRTF
95. Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres
96. Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes
97. Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2
98. rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye
99. A single amino acid can determine the DNA binding specificity of homeodomain proteins
100. Substituting an α-helix switches the sequence-specific DNA interactions of a repressor
101. Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells
102. Vertebrate homeodomain proteins: families of region-specific transcription factors