메뉴 건너뛰기
Tetrahedron Letters
Volumn 31, Issue 49, 1990, Pages 7197-7200
Covalent alkylation of dna with duocarmycin A. Identification of abasic site structure
Author keywords

[No Author keywords available]
Indexed keywords

DUOCARMYCIN A;
EID: 0025600433     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)97278-2     Document Type: Article
Times cited : (107)
References (17)
  • 12
    • 84918640815 scopus 로고    scopus 로고
    • 6, TSP) δ 1.41 (s, 3 H), 3.58 (s, 3 H), 3.79 (s, 3 H), 3.81 (s, 3 H), 3.92 (s, 3 H), 4.22 (m, 1 H), 4.41 (t, 1 H, J = 10.5 Hz), 4.49 (dd, 1 H, J = 13.5, 6.9 Hz), 4.64 (dd, 1 H, J = 13.5, 5.4 Hz), 4.67 (dd, 1 H, J = 10.5, 2.4 Hz), 6.83, d, 1 [[Truncated]]
  • 13
    • 0025062410 scopus 로고
    • 6 and used for DNA synthesis without further purification. Synthesis of oligomers was performed on an Applied Biosystem 381A DNA synthesizer using the phosphoramidite method with 1 mmol column. For preparation of abasic site-containing oligomers by a different method, see
    • (1990) Tetrahedron Lett. , vol.31 , pp. 175
    • Iocono1    Gildea2    Mclaughlin3
  • 15
    • 84918609869 scopus 로고    scopus 로고
    • 3), 2.23 – 2.31 (m, 1 H, 2′), 2.40 (ddd, 1 H, J = 2.7, 6.6, 14.5 Hz, 2′), 3.54 – 3.72 (m, 4 H, 5′, 1′'), 3.74 – 3.81 (m, 1 H, 5′'), 3.86 – 3.92 (m, 1 H, 5′'), 4.04 – 4.08 (m, 1 H, 4′), 4.52 – 4.68 (m, 3 H, 3′, 3′', 4′'), 6.17 (t, 1 H, J = 6.8 Hz, 1′), 7.51 (s, 1 H, 6).
  • 16
    • 84918628099 scopus 로고    scopus 로고
    • Duocarmycin A was slowly decomposed to ring-opened products in aqueous neutral solution.
  • 17
    • 84918624283 scopus 로고    scopus 로고
    • Treatment of the mixture with hot alkali (0.1 N NaOH, 90 °C, 5 min) resulted in a clean formation of d(CGTATp).

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.