The Effect of Immunosuppressive Agents on the Induction of Nuclear Factors that Bind to Sites on the Interleukin 2 Promoter

Journal of Experimental Medicine

Volumn 172, Issue 6, 1990, Pages 1869-1872

  Granelli Piperno, Angela ^a   Nolan, Patricia ^a   Inaba, Kayo ^a   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; INTERLEUKIN 2; LYMPHOKINE; TACROLIMUS;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIBIOTICS, MACROLIDE; BASE SEQUENCE; CELL NUCLEUS; CELLS, CULTURED; CYCLOSPORINS; DEXAMETHASONE; DNA-BINDING PROTEINS; HELA CELLS; HUMAN; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; PROMOTER REGIONS (GENETICS); SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; TACROLIMUS; TETRADECANOYLPHORBOL ACETATE;

EID: 0025597092     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.172.6.1869     Document Type: Article

References (16)

1. Granelli-Piperno, A., K. Inaba, and R.M. Steinman. 1984. Stimulation of lymphokine release from T lymphoblasts: requirement for mRNA synthesis and inhibition by Cyclosporin A. J. Exp Med.160:1792.
2. Granelli-Pipeno, A., L. Andrus, and R.M. Steinman. 1986. Lymphokine and nonlymphokine mRNA levels in stimulated human T cells: kinetics, mitogen requirements, and effects of cyclosporin A. J. Exp Med.163:922.
3. Kronke, M., W.J. Leonard, J.M. Depper, S.K. Arya, F. Wong-Staal, R.C. Gallo, T.A. Waldman, and W.C. Greene. 1984. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. USA. 81:5214.
4. Elliot, J.F., Y. Lin, S.B. Mizel, R.C. Bleakley, D.G. Harnish, and V. Paetkau. 1984. Induction of interleukin 2 messenger RNA inhibited by Cyclosporin A. Science (Wash. DC).226:1439.
5. Tocci, M.J., D.A. Matkovick, K.À. Collier, P. Kwok, F. Dumont, S. Lin, S. Degudicibus, J.J. Siekierka, J. Chin, and N.I. Hutchinson. 1989. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol.143:718.
6. Arya, S.K., F. Wong-Staal, and R.C. Gallo. 1984. Dexa-methasone-mediated inhibition of human T cell growth factor and 7-interferon messenger RNA. J. Immunol.133:273.
7. Vacca, A., S. Martinotti, I. Screpanti, M. Maroder, M.P. Felli, A.R. Farina, A. Gismondi, S. Santoni, L. Frati, and A. Gu-lino. 1990. Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. J. Biol. Chem.265:8075.
8. Crabtree, G.R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science (Wash. DC).243:355.
9. Shaw, J.P., P.J. Utz, D.B. Durand, J.J. Toole, E.A. Emmel, and G.R. Crabtree. 1988. Identification of a putative regulator of early T cell activation genes. Science (Wash. DC).241:202.
10. Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res.11:1475.
11. Holbrook, N.J., M. Lieber, and G.R. Crabtree. 1984. DNA Sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus. Nucleic Acids Res.12:5005.
12. Chiu, R., M. Imagawa, R.J. Imbra, J.R. Bockoven, and M. Karin. 1987. Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature (Lond.). 329:648.
13. Nabel, G.J., C. Gorka, and D. Baltimore. 1988. T-cell-specific expression of interleukin 2: evidence for a negative regulatory site. Proc. Natl. Acad. Sci. USA.85:2934.
14. Emmel, E.A., C.L. Verweij, D.B. Durand, K.M. Higgins, E. Lacy, and G.R. Crabtree. 1989. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science (Wash. DC).246:1617.
15. June, C.H., J.A. Ledbetter, M.M. Gillespie, T. Lindsten, and C.B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol.7:4472.
16. Granelli-Piperno, A. 1988. In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A.J. Exp Med.168:1649.