Using Starburst Dendrimers as Linker Molecules To Radiolabel Antibodies

Bioconjugate Chemistry

Volumn 1, Issue 5, 1990, Pages 305-308

  Roberts, Jeanette C ^a   Adams, Yvonne E ^a   Tomalia, Donald ^b   Mercer Smith, Janet A ^c   Lavallee, David K ^d  

^a UNIVERSITY OF UTAH   (United States)

^b MICHIGAN MOLECULAR INSTITUTE   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CHELATING AGENT; COPPER; ETHYLENEDIAMINE DERIVATIVE; IMMUNOTOXIN; METHACRYLIC ACID METHYL ESTER; N 4 NITROBENZYL 5 (4 CARBOXYPHENYL) 10,15,20 TRIS(4 SULFOPHENYL)PORPHINE; N-4-NITROBENZYL-5-(4-CARBOXYPHENYL)-10,15,20-TRIS(4-SULFOPHENYL)PORPHINE; POLYMER; PORPHYRIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ISOTOPE LABELING; METHODOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ANTIBODIES; CHELATING AGENTS; CHEMISTRY; COPPER RADIOISOTOPES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ETHYLENEDIAMINES; IMMUNOTOXINS; ISOTOPE LABELING; METHYLMETHACRYLATES; MOLECULAR STRUCTURE; POLYMERS; PORPHYRINS;

EID: 0025492456     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc00005a001     Document Type: Letter

References (7)

1. Tomalia, D. A., Naylor, A. M., and Goddard, W. A. (1990) Starburst dendrimers-Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew. Chetn. Int. Ed. Engl. 29, 138–175.
2. Roberts, J. C., Figard, S. D., Mercer-Smith, J. A., Svitra, Z. V., Anderson, W. L., and Lavallee, D. K. (1987) Preparation and characterization of copper-67 porphyrin-antibody conjugates. J. Immunol. Methods 105, 153–164.
3. Mercer-Smith, J. A., Roberts, J. C., Figard, S. D., and Lavallee, D. K. (1988) The Development of Copper-67-Labeled Porphyrin-Antibody Conjugates. Antibody-Mediated Delivery Systems (J. D. Rodwell, Ed.) pp 317–352, Marcel Dekker, Inc., New York.
4. Roberts, J. C., Newmyer, S. L., Mercer-Smith, J. A., Schreyer, S. A., and Lavallee, D. K. (1989) Labeling antibodies with copper radionuclides using N-4-nitrobenzyl-5-(4-carboxyphe-nyl)-10, 15, 20-tris(4-sulfophenyl)porphine. Appl. Radiat. Isot. 40, 775–781.
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7. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–254.