Opiate withdrawal and the rat locus coeruleus: Behavioral, electrophysiological, and biochemical correlates

Journal of Neuroscience

Volumn 10, Issue 7, 1990, Pages 2308-2317

  Rasmussen, Kurt ^a,b   Beitner Johnson, Dana B ^a   Krystal, John H ^a   Aghajanian, George K ^a   Nestler, Eric J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN; NALTREXONE; PROTEIN KINASE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DRUG EFFECT; ENZYMOLOGY; LOCUS CERULEUS; MALE; METABOLISM; MORPHINE ADDICTION; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RAT; RAT STRAIN; REFERENCE VALUE; WITHDRAWAL SYNDROME;

ADENYLATE CYCLASE; ANIMAL; BEHAVIOR, ANIMAL; GTP-BINDING PROTEINS; LOCUS COERULEUS; MALE; MORPHINE DEPENDENCE; NALTREXONE; NEURONS; PROTEIN KINASES; RATS; RATS, INBRED STRAINS; REFERENCE VALUES; SUBSTANCE WITHDRAWAL SYNDROME; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025457883     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.10-07-02308.1990     Document Type: Article

References (3)

1. Abercrombie ED, Levine ES, Jacobs BL (1988) Microinjected morphine suppresses the activity of locus coeruleus noradrenergic neurons in freely moving cats. Neurosci Lett 86:334-338.
2. Aceto MD, Dewey WL, Portoghese PS, Takemori AE (1986) Effects of b-flunaltrexamine (b-FNA) on morphine dependence in rats and monkeys. Eur J Pharmacol 123:387-393.
3. Aghajanian GK (1978) Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature 267:186-188.