Synthesis of a New Class of 2,3-Dihydro-2-oxo-lH-benzimidazole-1-carboxylic Acid Derivatives as Highly Potent 5-HT3Receptor Antagonists

Journal of Medicinal Chemistry

Volumn 33, Issue 8, 1990, Pages 2101-2108

  Turconi, Marco ^a   Nicola, Massimo ^a   Quintero, Myrna Gil ^a   Maiocchi, Luciano ^a   Giraldo, Ettore ^a   Donetti, Arturo ^a   Micheletti, Rosella ^a,b  

^a Istituto De Angeli ^*  (United Kingdom)

^b Istituto di Ricerche Sigma Tau ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 2 OXO 1H BENZIMIDAZOLE 1 CARBOXYLIC ACID DERIVATIVE; BEMESETRON; ITASETRON; SEROTONIN 3 RECEPTOR; TROPISETRON; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MODEL; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROPHOTOMETRY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; BENZIMIDAZOLES; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; BRIDGED COMPOUNDS; CEREBRAL CORTEX; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; HYDROGEN BONDING; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; REFLEX; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0025369707     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00170a009     Document Type: Article

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