Effects of human growth hormone in men over 60 years old

New England Journal of Medicine

Volumn 323, Issue 1, 1990, Pages 1-6

  Rudman, Daniel ^a,b   Feller, Axel G ^c,d   Nagraj, Hoskote S ^c,d   Gergans, Gregory A ^c,d   Lalitha, Pardee Y ^c,d   Cohn, Lester ^c   Rudman, Inge W ^a   Schlenker, Robert A ^e   Mattson, Dale E ^f  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e ARGONNE NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ADIPOSE TISSUE; ADULT; AGE; AGED; ARTICLE; BLOOD LEVEL; BODY MASS; DRUG EFFECT; HUMAN; LEAN BODY WEIGHT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SKINFOLD; SUBCUTANEOUS DRUG ADMINISTRATION;

ADIPOSE TISSUE; AGED; AGED, 80 AND OVER; AGING; BODY COMPOSITION; BONE DENSITY; GROWTH HORMONE; HORMONES, SYNTHETIC; HUMAN; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGE; SKIN; SKIN AGING; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025368959     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199007053230101     Document Type: Article

References (35)

1. Rudman D. Growth hormone, body composition, and aging. J Am Geriatr Soc 1985; 33: 800–7.
2. Meites J. Neuroendocrine biomarkers of aging in the rat. Exp Gerontol 1988; 23: 349–58.
3. Finkelstein JW, Boyar RM, Roffwarg HP, Kream J, Hellman L. Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab 1972; 35: 665–70.
4. Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest 1981; 67: 1361–9.
5. Gemmons DR. Van Wyk JJ. Factors controlling blood concentration of somatomedin C. Clin Endocrinol Metab 1984; 13: 113–43.
6. Florini JR, Prinz PN, Vitiello MV, Hintz RL. Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone. J Gerontol 1985; 40: 2–7.
7. van Buul-Offers S, Van den Brande JL. The growth of different organs of normal and dwarfed Snell mice, before and during growth hormone therapy. Acta Endocrinol 1981; 96: 46–58.
8. Parra A, Argote RM, Garcia G, Cervantes C, Alatone S. Perez-Pasten E. Body composition in hypopituitary dwarfs before and during human growth hormone therapy. Metabolism 1979; 28: 851–7.
9. van der Werff ten Bosch JJ, Bot A. Effects of human pituitary growth hormone on body composition. Neth J Med 1987; 30: 220–7.
10. Crist DM, Peake GT, Mackinnon LT, Sibbitt WL Jr, Krancer JC. Exogenous growth hormone treatment alters body composition and increases natural killer cell activity in women with impaired endogenous growth hormone secretion. Metabolism 1987; 36: 1115–7.
11. J⊘rgensen JOL, Pedersen SA, Thuesen L, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989; 1: 1221–5.
12. Crist DM. Peake GT. Egan PA, Waters DL. Body composition response to exogenous GH during training in highly conditioned adults. J Appl Physiol 1988; 65: 579–84.
13. Salomon F, Cuneo RC, Hesp R, Sönksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989; 321: 1797–803.
14. Jones AJS, O'Connor JV. Chemical characterization of methionyl human growth hormone. In: Hormone drugs: proceedings of the FDA-USP Workshop on Drug and Reference Standards for Insulins, Somatropins, and Thyroid-axis Hormones, Bethesda, Maryland, May 19–21, 1982. Rockville, Md.: United States Pharmacopeial Convention, 1982:335–51.
15. Flynn MA, Nolph GB, Baker AS, Martin WM, Krause G. Total body potassium in acing humans: a longitudinal study, Am J Clin Nutr 1989; 50: 713–7.
16. Lawrence CM, Shuster S. Comparison of ultrasound and caliper measurements of normal and inflamed skin thickness, Br J Dermalol 1985; 112: 195–200.
17. Nagraj HS, Gergans GA, Mattson DE, Rudman IW, Rudman D. Osteopenia in the men of a Veterans Administration nursing home. Am J Clin Nutr 1990; 51: 100–6.
18. Goldberg AF, Mattson DE, Rudman D. The relationship of growth hormone to alveolar ridge atrophy in an older male nursing home population. Spec Care Dentist 1988; 8: 184–6.
19. Furlanetto RW, Underwood LE, Van Wyk JJ, D'Ercole AJ. Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 1977; 60: 648–57.
20. Unterman TG, Vazquez RM, Slas AJ, Martyn PA, Phillips LS. Nutrition and somatomedin. XIII. Usefulness of somatomedin-C in nutritional assessment. Am J Med 1985; 78: 228–34.
21. Hall K, Sara VR. Somatomedin levels in childhood, adolescence and adult life. J Clin Endocrinol Metab 1984; 13: 91–112.
22. Ho KY, Evans WS, Blizzard RM, et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987; 64: 51–8.
23. Thompson RG, Rodriguez A, Kowarski A, Blizzard RM. Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effect of prednisone. J Clin Invest 1972; 51: 3193–9.
24. Bierich JR. Multicentre clinical trial of authentic recombinant somatropin in growth hormone deficiency. Ada Paediatr Scand Suppl 1987; 337: 135–40.
25. Gunnarsson R, Wilton P. Clinical experience with genotropin worldwide: an update March 1987. Ada Paediatr Scand Suppl 1987; 337: 147–52.
26. Hintz RL. Plasma forms of somatomedin and the binding protein phenomenon. Clin Endocrinol Metab 1984; 13: 31–42.
27. Ikkos D, Ljunggren H, Luft R. The relation between extracellular and intracellular water in acromegaly. Ada Endocrinol 1956; 21: 211–25.
28. Penney DG, Dunbar JC Jr, Baylerian MS. Cardiomegaly and haemodynamics in rats with a transplantable growth hormone-secreting tumour. Cardiovasc Res 1985; 19: 270–7.
29. Rizza RA, Mandarino LJ, Gerich JE. Effects of growth hormone on insulin action in man: mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization, Diabetes 1982; 31: 663–9.
30. Binnerts A, Wilson JH, Lamberts SW. The effects of human growth hormone administration in elderly adults with recent weight loss. J Clin Endocrinol Metab 1988; 67: 1312–6.
31. Rosenbaum M, Gertner JM, Leibel RL. Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH-deficient children. J Clin Endocrinol Metab 1989; 69: 1274–81.
32. Marcus R, Butterfield G, Holloway L, et al. Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 1990; 70: 519–27.
33. Kelly PJ, Eisman JA, Stuart MC, Pocock NA, Sambrook PN, Gwinn TH. Somatomcdin-C, physical fitness, and bone density. J Clin Endocrinol Metab 1990; 70: 718–23.
34. Novak LP. Aging, total body potassium, fat-free mass, and cell mass in males and females between ages 18 and 85 years. J Gerontol 1972; 27: 438–43.
35. Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 1975; 93: 639–43.