Cyclosporin a inhibits endothelium-dependent, prostanoid-induced relaxation in human subcutaneous resistance vessels

Journal of Hypertension

Volumn 8, Issue 2, 1990, Pages 159-163

  Richards, Nicholas T ^a   Poston, Lucilla ^a,b   Hilton, Philip J ^a  

^a Renal Laboratory ^*  (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Cyclosporin; Endothelium dependent relaxation; Indomethacin; Methylene blue; Vasodilatory prostanoids

Indexed keywords

ACETYLCHOLINE; CYCLOSPORIN A; ENDOTHELIUM DERIVED RELAXING FACTOR; INDOMETACIN; NORADRENALIN; PROSTANOID;

ARTICLE; DRUG EFFECT; HUMAN; HUMAN CELL; MEDIATOR; RESISTANCE BLOOD VESSEL; VASODILATATION;

ACETYLCHOLINE; ADULT; CYCLOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMAN; INDOMETHACIN; METHYLENE BLUE; MIDDLE AGE; NITRIC OXIDE; SUPPORT, NON-U.S. GOV'T; VASCULAR RESISTANCE; VASODILATION;

EID: 0025368672     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/00004872-199002000-00010     Document Type: Article

References (15)

1. Bantle JP, Nath KA, Sutherland DER, Najarian JS, Ferris TF: Effects of cyclosporine on the renin-angiotensin-aldo-sterone system and potassium excretion in renal transplant recipients. Arch Intern Med 1985, 145:505-508.
2. Bantle JP, Boudreau FJ, Ferris TF: Suppression of plasma renin by cyclosporine. Am J Med 1987, 83:58-64.
3. Schachter M: Cyclosporine A and hypertension. J Hypertens 1988, 6:511-516.
4. Golub MS, Berger ME: Direct augmentation by cyclosporine A of the vascular contractile response to nerve stimulation. Hypertension 1987, 9:96-100.
5. Lamb FS, Webb RC: Cyclosporin augments reactivity of isolated blood vessels. Life Sci 1987, 40:2571-2578.
6. XUE H, BUKOSKI RD, McCARRON DA, Bennett WM: Induction of contraction in isolated rat aorta by cyclosporine. Transplantation 1987, 43:715-718.
7. Brown Z, Nield GH: Cyclosporin inhibits prostacyclin production by cultured human endothelial cells. Transplant Proc 1987, 19:1178.
8. Gordon JA, Hadjiagapiou C, Spector AA: Cyclosporine inhibits prostacyclin formation in cultured human endothelial cells. Kidney Int 1987, 31:457.
9. Richards NT, Poston L, Hilton PJ: Cyclosporin inhibits relaxation but does not induce vasoconstriction in human subcutaneous resistance vessels. J Hypertens 1989, 7:1-3.
10. Mulvany MJ, Hansen PK, Aalkjaer C: Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrower lumen, a thicker media, and an increased number of smooth muscle cell layers, Circ Res 1978, 43:854-864.
11. Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, 299:373-376.
12. LUSCHER TF, COOKE JP, HOUSTON DS, NEVES R, VANHOUTTE PM: Endothelium-dependent relaxations in human arteries. Mayo Clin Proc 1987, 62:601-606.
13. LUSCHER TF, ROMERO JC, VANHOUTTE PM: Biopsy of endothelium-derived vasoactive substances in the aorta of normotensive and spontaneously hypertensive rats. J Hypertens 1986, 4 (suppl 6):S81-S83.
14. Clark DL, Linden J: Modulation of guanylate cyclase by lipo-xygenase inhibitors. Hypertension 1986, 8:947-950.
15. 1 analog misopros-tol on cyclosporine nephrotoxicity. Transplantation 1988, 45:1126-1131.