Kinetic Investigation of the Functional Role of Phenylalanine-31 of Recombinant Human Dihydrofolate Reductase

Biochemistry

Volumn 29, Issue 27, 1990, Pages 6428-6436

  Tsay, Jiu Tsair ^a,b,c   Appleman, James R ^a,b,c   Beard, William A ^a,b,c   Prendergast, Neal J ^a,b,c   Delcamp, Tavner J ^a,b,c   Freisheim, James H ^a,b,c   Blakley, Raymond L ^a,b,c  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; RECOMBINANT PROTEIN;

ARTICLE; ENZYME KINETICS; GENETIC ENGINEERING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BACTERIAL PROTEINS; BINDING SITES; BIOPTERIN; COMPARATIVE STUDY; ESCHERICHIA COLI; HUMAN; HYDROGEN-ION CONCENTRATION; KINETICS; LEUCINE; PHENYLALANINE; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRAHYDROFOLATE DEHYDROGENASE; TETRAHYDROFOLATES;

FELIS CATUS;

EID: 0025365480     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00479a014     Document Type: Article

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