Potent Inhibition of Thymidylate Synthase by Two Series of Nonclassical Quinazolines

Journal of Medicinal Chemistry

Volumn 33, Issue 7, 1990, Pages 2045-2051

  McNamara, Dennis J ^a   Berman, Ellen M ^a   Werbel, Leslie M ^a   Fry, David W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; 10 PROPARGYL 5,8 DIDEAZAFOLIC ACID DERIVATIVE; DIHYDROFOLATE REDUCTASE; QUINAZOLINE DERIVATIVE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; LEUKEMIA L 1210; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; COMPARATIVE STUDY; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMAN; INDICATORS AND REAGENTS; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0025365265     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00169a040     Document Type: Article

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