The concept of selectivity in 5-HT receptor research

European Journal of Pharmacology: Molecular Pharmacology

Volumn 188, Issue 6, 1990, Pages 301-312

  Van Wijngaarden, I ^a   Tulp, M Th M ^a   Soudijn, W ^b  

^a Solvay Pharmaceuticals Inc   (Netherlands)

^b Clinical Pharmacology   (Netherlands)

Author keywords

(Receptor binding profiles); (Selectivity); 5 HT receptor agonists; 5 HT receptor antagonists; 5 HT receptor subtypes

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; 3 (5 METHYL 1H IMIDAZOL 4 YL) 1 (1 METHYL 1H INDOL 3 YL) 1 PROPANONE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; BEMESETRON; BUSPIRONE; FLESINOXAN; GRANISETRON; IPSAPIRONE; KETANSERIN; MESULERGINE; ONDANSETRON; PHENYLBIGUANIDE; QUIPAZINE; RADIOISOTOPE; RECEPTOR SUBTYPE; RENZAPRIDE; RITANSERIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1C RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; SUMATRIPTAN; SUMATRIPTAN SUCCINATE; TROPISETRON; ZACOPRIDE;

ARTICLE; BRAIN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; HUMAN; RADIOLIGAND ASSAY; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, SEROTONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0025351443     PISSN: 09224106     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-4106(90)90190-9     Document Type: Article

References (47)

1. 1A receptors in the brain
2. 2 receptors
3. 3 receptor antagonist properties of ICS 205,930, GR 38032F and zacopride
4. 2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat
5. Central serotonin receptors: effector systems, physiological roles and regulation
6. 3 receptor agonist and antagonists for alteration of aversive behaviour in the mouse
7. Ketanserin binds to the monoamine transporter of chromaffine granules and of synaptic vesicles
8. 2 receptors
9. 4) positively coupled to adenylate cyclase
10. 3 receptor
11. 3 receptors and cytotoxic drug-induced vomiting
12. IA agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)
13. 3H]-tryptamine binding sites of rat cerebral cortex: pharmacological profile and plasticity
14. 3H]paroxetine binding to rat cortical membranes
15. Molecular biology of 5-HT receptors
16. 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes
17. IA receptors
18. 1 recognition sites
19. 1C receptors
20. 3 recognition sites by radioligand binding in NG108-15 neuroblastoma-glioma cells
21. 1-adrenoceptor in human and pig brain membranes
22. 3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervival ganglion
23. 3 receptors in rat brain using radioligand binding
24. 3H]GR 65630, to rat area postrema, vagus nerve and the brains of several species
25. IE) in human brain: interaction with a GTP-binding protein
26. Mannich bases of 2,3-dihydro-4(1H)-carbazolones as potential psychotropic agents
27. 1A receptors
28. 1C receptor is a prominent serotonin receptor subtype in the central nervous system
29. Effects of MDL 73005EF in animal models predictive of anxiolytic activity
30. 1A serotonin binding sites
31. The binding of serotonergic ligands to the porcine choroid plexus characterization of a new type of serotonin recognition site
32. 1D binding sites
33. 3 antagonists
34. 3 binding sites
35. Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis
36. 5-Hydroxytryptamine receptor ‘families’
37. 1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus
38. 1B receptor ligands exist?
39. Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
40. 1A receptor-related anxiolytics
41. 3 receptors suggest new treatments for psychosis and drug addiction
42. 3H]-cholecystokinin-8 as radioligand
43. 3 recognition sites in neuroblastoma cell lines and mammalian CNS
44. 1A receptors
45. 1A receptor in rat and guinea pig hippocampal membranes