Effect of Simvastatin (MK-733) on Sterol and Bile Acid Excretion in Rabbits

the japanese journal of pharmacology

Volumn 53, Issue 1, 1990, Pages 35-45

  Fumiaki, Ishida ^a   Yuri, Iizuka ^a   Kyoko, Kakubari ^a   Yutaka, Kurahashi ^a   Yoshio, Sawasaki ^a   Toshio, Kamei ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; COLESTYRAMINE; SIMVASTATIN;

ARTICLE; BODY WEIGHT; CHOLESTEROL DIET; FECES LEVEL; FOOD INTAKE; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPID METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STEROL EXCRETION;

ANIMAL; BILE; BILE ACIDS AND SALTS; CHOLESTEROL, DIETARY; CHOLESTYRAMINE; FECES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPIDS; LIVER; LOVASTATIN; MALE; RABBITS; SIMVASTATIN; STEROLS;

EID: 0025349255     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.53.35     Document Type: Article

References (29)

1. Alberts, A.W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghann, R., Currie, S., Stapley, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J. and Springer, J,: Mevinolin: A highly potent competitive inhibitor of hydroxy methyl-glutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. U.S.A. 77, 3957-3961 (1980)
2. Hoffman, W.F., Alberts, A.W., Anderson, P.S., Chen, J.S., Smith, R.L. and Willard, A.K.: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. J. Med. Chem. 29, 849-852 (1986)
3. Kobayashi, M., Ishida, F., Takahashi, T., Taguchi, K., Watanabe, K., Ohmura, I. and Kamei, T.: Preventive effect of MK-733 (Simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits. Japan. J. Pharmacol. 49, 125-133 (1989)
4. Ishida, F., Sato, A., Lizuka, Y., Sawasaki, Y., Aizawa, A. and Kamei, T.: Effect of MK-733, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, on absorption and excretion of [3H]-cholesterol in rabbits. Biochim. Biophys. Acta 963, 35-41 (1988)
5. Dietchy, J.M. and Wilson, J.D.: Regulation of cholesterol metabolism (Three parts). N. Engl. J. Med. 282, 1128-1138, 1179-1183, 1241-1249 (1971)
6. Schwartz, C.C., Berman, M., Vlahcevic, Z.R., Halloran, L.G., Gregory, D.H. and Swell, L.: Multicompartmental analysis of cholesterol metabolism in man. I. Characterization of the hepatic bile acid and biliary cholesterol precursor sites. J. Clin. Invest. 61, 408-423 (1978)
7. Schwartz, C.C., Vlahcevic, Z.R., Halloran, L.G. and Swell, L,: An in vivo evaluation in man of the transfer of esterified cholesterol between lipoproteins and into the liver and bile. Biochim. Biophys. Acta 663, 143-162 (1981)
8. Tennet, D.M., Siegel, H., Zanetti, M.E., Kuron, G.W., Ott, W.H. and Wolf, F.J.: Plasma cholesterol lowering action of bile acid binding polymers in experimental animals. J. Lipid Res. 1, 469-473 (1960)
9. Huff, J.W., Gilfillan, J.L. and Hunt, V.M.: Effects of cholestyramine, a bile acid binding polymer on plasma cholesterol and fecal bile acid excretion in the rats. Proc. Soc. Exp. Biol. Med. 114, 352-355 (1963)
10. Hashim, S.A. and Van Itallie, T.B.: Cholestyramine resin therapy for hypercholesterolemia: Clinical and metabolic studies. JAMA 192, 289-293 (1965)
11. Brown, M.S. and Goldstein, J.L.: Drugs used in the treatment of hyperlipoproteinemias, In The Pharmacological Basis of Therapeutics, Edited by Gilman. A.G. Goodman, L.S. Rail, T.W. and Murad, F., p. 839-841, MacMillan Publishing Company, New York (1985)
12. Folch, J., Lees, M. and Sloane-Stanley, G.H.: A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509 (1957)
13. Imai, Y., Kawata, S., Inada, M., Miyoshi, S., Minami, Y., Matsuzawa, Y., Uchida, K. and Tarui, S.: Effect of cholestyramine on bile acid metabolism in conventional rats. Lipids 22, 513-516 (1987)
14. Huff, M.W. and Carroll, K.K.: Effects of dietary protein on turn over, oxidation and absorption of cholesterol, and steroid excretion in rabbits. J. Lipid Res. 21, 546-558 (1980)
15. Siegel, S.: Nonparametric Statistics: For the Behavioral Sciences. McGraw-Hill Book, New York (1956)
16. Heider, J.G., Pickens, C.E. and Kelly, L.A.: Role of acyl CoA: cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbits. J. Lipid Res. 24, 1127-1134 (1983)
17. Ishida, F., Sato, A., Iizuka, Y., Kitani, K., Sawasaki, Y. and Kamei, T.: Effects of MK-733 (simvastatin), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on intestinal acyl coenzyme A: cholesterol acyltransferase activity in rabbits. Biochim. Biophys. Acta 1004, 117-123 (1989)
18. Khan, B., Wilcox, H.G. and Heimberg, M.: Cholesterol is required for secretion of very-low-density lipoprotein by rat liver. Biochem. J. 258, 807-816 (1989)
19. Hill, M.J. and Draser, B.S.: Bacterial degradation of bile salt. Biochem. J. 104, 55-56 (1967)
20. Edenharder, R. and Schneider, J.: 12β-Dehydrogeneration of bile acids by Clostridium paraputrificum, C. tertium and C. difficile and epimerization at carbon-12 of deoxycholic acid by cocultivation with 12α-dehydrogenating Eubacterium ientum. Appl. Environ. Microbiol. 49, 964-968 (1985)
21. Hellstrom, K.: On the bile and neutral fecal steroid excretion in man and rabbits following cholesterol feeding. Acta Physiol. Scand. 63, 21-35 (1965)
22. Admirand, W.H. and Small, D.M.: The physico-chemical basis of cholesterol gallstone formation in man. J. Clin. Invest. 47, 1043-1052 (1968)
23. Holtzbach, R.T., March, M. and Olszewski, M.: Cholesterol solubility in bile; evidence that supersaturated bile is frequent in healthy man. J. Clin. Invest. 52, 1467-1479 (1973)
24. Carey, M.C. and Small, D.M.: The physical chemistry of cholesterol solubility in bile. J. Clin. Invest. 60, 998-1026 (1978)
25. Endo, A., Kuroda, M. and Tsujita, Y.: ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penic/lhum citr/num. J. Antibiot. 29, 1346-1348 (1976)
26. Serizawa, N., Nakagawa, K., Hamano, K., Tsujita, Y., Terahara, A. and Kuwano, H.: Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B). J. Antibiot. 36, 604-607 (1983)
27. Serizawa, N., Nakagawa, K., Tsujita, Y., Terahara, A. and Kuwano, H.: α-Hydroxy-ML-236B (α-hydroxycompactin), microbial transformation product of ML-236B (compactin). J. Antibiot. 36, 608-610 (1983)
28. Tsujita, Y., Kuroda, M., Shimada, Y., Tanzawa, K., Arai, M., Kaneko, I., Tanaka, M., Masuda, H., Tarumi, C., Watanabe, Y, and Fujii, S.: CS-51 4, a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species. Biochim. Biophys. Acta 877, 50-60 (1986)
29. Duane, W.C., Hunninghake, B.H., Freeman, M.L., Pooler, P.A., Schlasner, L.A. and Gebhard, R.L.: Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile. Hepatology 8, 1147-1150 (1988)