Cholinergic cell loss and cognitive impairments following intraventricular or intradentate injection of colchicine

Brain Research

Volumn 517, Issue 1-2, 1990, Pages 157-167

  Emerich, Dwaine F ^a   Walsh, Thomas J ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Cholinergic neuron; Cholinotoxicity; Colchicine; Dentate gyrus; Hippocampus; Microtubule disrupting agent; Radial arm maze; Septohippocampal pathway

Indexed keywords

CHOLINE ACETYLTRANSFERASE; COLCHICINE; RADIOISOTOPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLINE UPTAKE; CHOLINERGIC NERVE CELL; DENTATE GYRUS; HIPPOCAMPUS; HISTOCHEMISTRY; MALE; MEMORY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTUM NUCLEUS;

ANIMAL; CELL COUNT; CEREBRAL VENTRICLES; CHOLINERGIC FIBERS; COGNITION DISORDERS; COLCHICINE; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROTOXINS; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025349056     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(90)91021-8     Document Type: Article

References (56)

1. A unifying hypothesis for the cause of lateral sclerosis, Parkinsonism and Alzheimer's disease
2. Neuronal loss, neurofibrillary tangles, and granulovascular degeneration with ageing and dementia
3. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
4. The cholinergic hypothesis of geriatric memory dysfunction
5. The physiology and pharmacology of hippocampal formation theta rhythms
6. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
7. Recent advances in histochemical techniques for the study of central cholinergic mechanisms
8. AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates
9. Cholinergic innervation of the rat dentate gyrus. An immunocytochemical and electron microscopical study
10. Alzheimer's disease: a disorder of cortical cholinergic innervation
11. The effects of colchicine in mammalian brain from rodents to rhesus monkeys
12. Selective working memory impairments following intradentate injection of colchicine: attenuation of the behavioral but not the neuropathological effects by gangliosides GM1 and AGF2
13. Brain damage and neuroplasticity: mechanisms of recovery or development?
14. Radiochemical microassays for the determination of cholineacetyltransferase and acetylcholinesterase activities
15. Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study
16. The cholinergic innervation of the rat fascia dentata: identification of target structures on granule cells by combining choline acetyltransferase immunocytochemistry and Golgi impregnation
17. Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents
18. Functional correlates of compensatory collateral sprouting by aminergic and cholinergic afferents in the hippocampal formation
19. Nerve growth factor promotes development of the rat septohippocampal cholinergic projection in vitro
20. Plasticity of hippocampal circuitry in Alzheimer's disease
21. Neurotoxic effects of colchicine: differential susceptibility of CNS neuronal populations
22. Long-term potentiation in the dentate gyrus is preferentially induced at theta rhythm periodicity
23. A modified histochemical technique to visualize acetylcholinesterase-containing axons
24. Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transections
25. Nerve growth factor and Alzheimer's disease
26. A ‘direct-coloring’ thiocholine method for cholinesterase
27. Treatment with 6-hydroxydopamine and cholchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in the corresponding target tissues
28. Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation
29. Nerve growth factor treatment after brain injury prevents neuronal death
30. Pattern stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation
31. Microdetermination of choline acetyltransferase in nervous tissue
32. Terminal proliferation in the partially deafferented dentate gyrus: time courses for the appearance and removal of degeneration and the replacement of lost terminals
33. Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1–Ch6)
34. Analysis of the time course of changes in hippocampal acetylcholinesterase and choline acetyltransferase activities after various septal lesions in the rat: return of enzymatic activity after extensive medioventral lesions
35. Memory functions and the hippocampus
36. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
37. Direct neurotoxic effects of colchicine on cholinergic neurons in medial septum and striatum
38. A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei
39. Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations including Alzheimer's disease
40. Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting
41. Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat
42. Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine
43. The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration
44. Neurotoxicity of colchicine and other tubulin-binding agents: a selective vulnerability of certain neurons to the disruption of microtubules
45. The hippocampus as a common target of neurotoxic agents
46. GM1 ganglioside attenuates the behavioral deficits but not the granule cell damage produced by intradentate colchicine
47. Colchicine-induced granule cell loss in rat hippocampus: selective behavioral and histological alterations
48. 3H]choline into acetylcholinergic neurons of the nucleus basalis magnocellularis and medial septum area
49. Alzheimer's disease: correlation of cortical choline acetyltransferase activity with severity of dementia and histological abnormalities
50. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection