Signal transduction by receptors with tyrosine kinase activity

Cell

Volumn 61, Issue 2, 1990, Pages 203-212

  Ullrich, Axel ^a   Schlessinger, Joseph ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; RECEPTOR;

CELL TRANSFORMATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; CELL MEMBRANE; HUMAN; MODELS, BIOLOGICAL; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0025343230     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(90)90801-K     Document Type: Review

References (91)

1. Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae
2. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
3. Alteration of epidermal growth factor receptor activity by mutation of its primary carboxy-terminal site of self phosphorylation
4. Mechanism of EGF-receptor autophosphorylation and high affinity binding
5. Recycling receptors: the round-trip itinerary of migrant membrane proteins
6. Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor
7. Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
8. Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin
9. Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent
10. Signal transmission by the insulin-like growth factors
11. Independent mechanisms account for the regulation by protein kinase-C of the EGF-receptor affinity and tyrosine-protein kinase activity
12. Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells
13. Phospholipase C-γ, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine residues during the mitogenic response to CSF-1
14. A PDGF receptor domain essential for mitogenesis but not for other responses to PDGF
15. Kinase activity controls the sorting of EGF receptor within the multivesicular body
16. Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies
17. EGF binding induces a conformational change in the external domain of its receptor
18. Analysis of mammalian fibroblasts transformation by normal and mutated human EGF receptors
19. Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer
20. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
21. Identification of autophosphorylation sites of HER2/neu
22. Dimerization of the B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation
23. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
24. A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis
25. Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites
26. Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites
27. Evidence that autophosphorylation of solubilized EGF-receptors is mediated by intermolecular cross phosphorylation
28. Evidence for EGF-induced intermolecular autophosphorylation of the EGF-receptor in living cells
29. Separate endocytic pathways of kinase-defective and active EGF-receptor mutant expression in the same cells
30. HER2 causes transformation and tumorigenesis of NIH 3T3 cells
31. Ligand-induced stimulation of EGF-receptor mutants with altered transmembrane regions
32. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
33. Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts
34. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors
35. Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C
36. Signal transduction in hamster fibroblasts overexpressing the human EGF-receptor
37. Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains
38. Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric human/chicken receptor molecules
39. HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor
40. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor
41. Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms
42. Reconstitution of human epidermal growth factor receptor and its deletion mutants in cultured hamster cells
43. An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions
44. Release of phorbol ester-induced mitogenic block by mutation at Thr-654 of epidermal growth factor receptor
45. 2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells
46. All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxy-terminal tails: identification of a novel site in EGF receptor
47. EGF induces phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signalling
48. Tyrosine kinase activity is essential for the association of phospholipase C-γ with EGF-receptor
49. 3 formation but not calcium signaling and mitogenesis
50. A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis
51. Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
52. PDGF induction of tyrosine phosphorylation of GTPase activating protein
53. A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction
54. Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF β-receptor
55. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
56. Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains
57. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
58. Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization
59. Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library
60. Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization
61. A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor
62. Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts
63. Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors
64. Phosphorylation activates the insulin receptor tyrosine kinase
65. Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)
66. A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential
67. The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation
68. Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG)
69. Signal transduction by allosteric receptor oligomerization
70. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors
71. Primary structure of a putative receptor for a ligand of the insulin family
72. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
73. Immunological relationships between receptors for insulin and insulin-like growth factor I.
74. neu stimulates tyrosine phosphorylation in vivo
75. The unique insert of cellular and viral fms protein tyrosine-kinase domains is dispensable for enzymatic and transforming activities
76. Relationship of site-specific β subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity
77. The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase
78. Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene
79. Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation
80. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium
81. Hormone binding site of the insulin receptor: analysis using photoafffinity-mediated avidin complexing
82. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation
83. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity
84. Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system
85. Signal transduction by the platelet-derived growth factor receptor
86. Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tulocus in Xinophophorus
87. Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype
88. EGF receptor self-phosphorylation is mediated by an intermolecular allosteric process
89. Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation
90. Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor
91. Growth factor receptor tyrosine kinases