Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

FEBS Letters

Volumn 268, Issue 1, 1990, Pages 235-237

  Klibanov, Alexander L ^a,b   Maruyama, Kazuo ^a   Torchilin, Vladimir P ^b   Huang, Leaf ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

Author keywords

chol, cholesterol; Drug delivery system; DTPA, diethylenetriaminepentaacetic acid; DTPA SA, DTPA stearylamide; Liposome; PBS, phosphate buffered saline; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PEG, polyethyleneglycol; PEG OSu, monomethoxy polyethyleneglycol succinimidyl succinate; PEG PE, dioleoyl N (monomethoxy polyethyleneglycol succinyl) PE; Polyethyleneglycol; RES, reticuloendothelial system

Indexed keywords

LIPOSOME; MACROGOL;

ANIMAL EXPERIMENT; ARTICLE; DRUG DELIVERY SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; HUMAN; IN VITRO; LIPOSOMES; LIVER; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED BALB C; PERMEABILITY; POLYETHYLENE GLYCOLS; SPLEEN; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0025341615     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(90)81016-H     Document Type: Article

References (18)

1. Lipid composition is important for highly efficient target binding and retention of immunoliposomes.
2. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
3. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.