Mutations in paramecium calmodulin indicate functional differences between the C-terminal and N-terminal lobes in vivo

Cell

Volumn 62, Issue 1, 1990, Pages 165-174

  Kink, John A ^a   Maley, Margot E ^a   Preston, Robin R ^a   Ling, Kit Yin ^a   Wallen Friedman, Margaret A ^a   Saimi, Yoshiro ^a   Kung, Ching ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALMODULIN;

ARTICLE; MEMBRANE TRANSPORT; MUTANT; MUTATION; NONHUMAN; PARAMECIUM; PRIORITY JOURNAL; PROTOZOON;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CALMODULIN; COMPARATIVE STUDY; GENES, STRUCTURAL; MOLECULAR SEQUENCE DATA; MUTATION; PARAMECIUM; POTASSIUM CHANNELS; PROTEIN CONFORMATION; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

PARAMECIUM; PARAMECIUM TETRAURELIA; PROTOZOA;

EID: 0025338528     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(90)90250-I     Document Type: Article

References (61)

1. Three-dimensional structure of calmodulin
2. Structure of calmodulin refined at 2.2 Å resolution
3. Rain-, wind-, and touch-induced expression of calmodulin and calmodulin-related genes in Arabidopsis
4. Biochemical characterization of genetically altered calmodulin in Paramecium
5. Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression
6. Site-specific mutagenesis of the α helices of calmodulin
7. Isolation of the yeast calmodulin gene: calmodulin is an essential protein
8. Structure and expression of genes for surface proteins in Paramecium
9. Nucleotide sequence of a macronuclear DNA molecule coding for α-tubulin from the ciliate Stylonychia lemnae
10. Calcium binding to skeletal muscle troponin C and the regulation of muscle contraction
11. Genetic analysis of axonemal mutants in Paramecium tetraurelia defective in their response to calcium
12. 2+ channel properties in Paramecium tetraurelia: isolation, characterization and genetic analysis
13. A genetic and biochemical analysis of behavior in Paramecium
14. + current missing in á mutant of Paramecium
15. An unusual genetic code in nuclear genes of Tetrahymena
16. Calmodulin
17. Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes
18. Structure and evolution of calcium-modulated proteins
19. Genic mutations with altered system of excitation in Paramecium aurelia. I. Phenotypes of the behavioral mutants
20. Genic mutations with altered system of excitation in Paramecium aurelia. II. Mutagenesis, screening and genetic analysis of the mutations
21. Genetic modifications of electric properties in an excitable membrane
22. Identification of multiple species of calmodulin messenger-RNA using a full length complementary DNA
23. Genetic analysis of membrane differentiation in Paramecium
24. In vivo mutations of calmodulin: a mutant Paramecium with altered ion current regulation has an isoleucine-to-threonine change at residue 136 and an altered methylation state at lysine residue 115
25. Codon usage in Tetrahymena and other ciliates
26. Molecular mechanisms of action of calmodulin
27. Genetic applications of an inverse polymerase chain reaction
28. Separation of membrane currents using a Paramecium mutant
29. A galactose-dependent cmd 1 mutant of Saccharomyces cerevisiae involvement of calmodulin in nuclear division
30. How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices
31. The central helix of calmodulin functions as a flexible tether
32. Synchronous exocytosis in Paramecium cells. I. A novel approach
33. Deviation from the universal genetic code shown by the gene for the surface protein 51A in Paramecium
34. + currents in two pantophobiac mutants of Paramecium tetraurelia
35. 3′ non-coding region sequences in eukaryotic messenger RNA
36. Chicken calmodulin genes
37. Genetically engineered calmodulins differentially activate target enzymes
38. Functional significance of the central helix in calmodulin
39. A genetic dissection of ion-channel functions
40. Calmodulin is involved in regulation of cell proliferation
41. Calmodulin is a major component of extruded trichocysts from Paramecium
42. Calcium-dependent sodium currents in Paramecium: mutational manipulations and effects of hyper- and depolarization
43. + current in Paramecium
44. Behavioral genetics of Paramecium
45. + current shuts off one type of excitation in Paramecium
46. +-outward current in Paramecium tetraurelia
47. Amino acid sequence of a novel calmodulin from Paramecium tetraurelia that contains dimethyllysine in the first domain
48. A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation
49. Methods in Paramecium Research
50. Paramecium aurelia
51. Calmodulin and its role in intracellular calcium regulation
52. Crystal structure of the helix-loop-helix calcium-binding proteins
53. Analysis and in vivo disruption of the gene coding for calmodulin in Schizosaccharomyces pombe
54. Substitution at position 116 of Schizosaccharomyces pombe calmodulin decreases its stability under nitrogen starvation and results in a sporulation-deficient phenotype
55. 2+-ATPase in exocytosis performance in Paramecium tetraurelia cells
56. Conditions for reproducible detection of calmodulin and S100 β in immunoblots
57. Genetic analyses of “Paranoiac” mutants of Paramecium tetraurelia
58. An ion current mutant of a Paramecium tetraurelia with defects in the primary structure and post-translational N-methylation of calmodulin