Synthesis and structure determination of FR109615, a new antifungal antibiotic

The Journal of Antibiotics

Volumn 43, Issue 5, 1990, Pages 513-518

  Kawabata, Kohji ^a   Inamoto, Yoshiko ^a   Sakane, Kazuo ^a   Iwamoto, Toshiro ^a   Hashimoto, Seiji ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOCYCLOPENTANECARBOXYLIC ACID;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA TROPICALIS; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; X RAY ANALYSIS;

ANTIBIOTICS, ANTIFUNGAL; CANDIDA; CANDIDA ALBICANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOLEUCINE; ISOMERISM; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STREPTOMYCES; X-RAY DIFFRACTION;

EID: 0025338480     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.43.513     Document Type: Article

References (5)

1. Iwamoto, T.; E. Tsujii, M. Ezaki, A. Fujie, S. Hashimoto, M. Okuhara, M. Kohsaka, H. Imanaka, K. Kawabata, Y. Inamoto & K. Sakane: FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. J. Antibiotics 43: 1∼7, 1990.
2. Oki, T.; M. Nishio, K. Saitoh, M. Hirano, T. Miyaki, M. Konishi & H. Kawaguchi: Cispentacin, a new antifungal antibiotic. Chemistry and biological activity. Program and Abstracts of the 29th Intersci. Conf. on Antimicrob. Agents Chemother. No. 716, p. 221, Houston, Sept. 17∼20, 1989.
3. Nativ, E. & P. Rona: 2-Azabicyclo[3.2.0]heptane-3-one. Isr. J. Chem. 10: 55∼58, 1972.
4. Edman, P.: Method for determination of the amino acid sequence in peptides. Acta Chem. Scand. 4: 283∼293, 1950.
5. Plieninger, H. & K. Schneider: Die Analagerung von Ammoniak an Δ1-Tetrahydrobenzoesäure und Cyclopenten-(1)-carbon-säure-(1) und die eindeutige sterische Zuordung der entstehenden β-Aminosäuren. Chem. Ber. 92: 1594∼1599, 1959.