Protein kinase C is localized in focal contacts of normal but not transformed fibroblasts

Molecular Carcinogenesis

Volumn 3, Issue 2, 1990, Pages 45-53

  Hyatt, Susannah L ^a   Klauck, Theresa ^a   Jaken, Susan ^a  

^a Adirondack Biomedical Research Institute Inc   (United States)

Author keywords

cystoskeleton; Key words; phorbol esters; Protein kinase C; transformation

Indexed keywords

PHORBOL ESTER; PROTEIN KINASE C; RADIOISOTOPE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL TRANSFORMATION; CYTOCHEMISTRY; CYTOSKELETON; FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CYTOSKELETON; DOWN-REGULATION; ENZYME ACTIVATION; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; ISOENZYMES; PHORBOL 12,13-DIBUTYRATE; PHORBOL ESTERS; PROTEIN KINASE C; RATS; RECEPTORS, DRUG; SIMIAN VIRUS 40; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VASOPRESSINS;

ANIMALIA;

EID: 0025330085     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.2940030202     Document Type: Article

References (34)

1. Studies and perspectives on protein kinase C
2. Direct activation of calcium‐activated, phospholipid‐dependent protein kinase by tumor‐promoting phorbol esters
3. Phorbol diester receptor copurifies with protein kinase C
4. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
5. 2+‐ activated and phospholipid‐dependent protein kinase
6. Purification and characterization of three types of protein kinase C from rabbit brain cytosol
7. Mode of activation and kinetic properties of three distinct forms of protein kinase C from rat brain
8. Effect of SV40 transformation on the growth factor requirements of the rat embryo cell line REF52 in serum‐free medium
9. In vitro correlates of tumorigenicity of REF52 cells transformed by simian virus 40
10. Action of phorbol esters in cell culture: Mimicry of transformation, altered differentiation, and effects on cell membranes
11. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
12. Quantitative measurement of sn‐1,2‐diacylglycerols present in platelets, hepatocytes, and ras‐and sis‐ transformed normal rat kidney cells
13. Protein kinase C in fibroblasts
14. Vasopressin is the only component of serum‐free medium that stimulates phosphatidylcholine hydrolysis and accumulation of diacylglycerol in cultured REF52 cells
15. Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: Transformed derivatives do not respond
16. Monoclonal antibodies specific for Type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitrofunctional activity
17. Diacylglycerol: The role of stimulated production in the activation of protein kinase C
18. Immunofluorescence and immunocytochemical procedures
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Measurement of phorbol ester receptors in intact cells and subcellular fractions
21. 1 rat pituitary cells
22. r 110,000/115,000 polypeptides enriched in cytoskeletal and postsynaptic density preparations
23. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
24. 2+, phospholipid‐dependent protein kinase associated with plasma membrane
25. Homologous and heterologous desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps
26. Specific desensitization to tumor‐promoting phorbol esters in mouse pituitary cells
27. 1 rat pituitary cells
28. Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts
29. Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells
30. Adhesion plaques: Sites of transmembrane interaction between the extracellular matrix and the actin cytoskeleton
31. Molecular interactions in adherens‐type contacts
32. Amphitrophic proteins: A new class of membrane proteins
33. Phosphotyrosinecontaining proteins are concentrated in focal adhesions and intercellular junctions in normal cells