Antiviral Agents of Plant Origin: III: Scopadulin, a Novel Tetracyclic Diterpene from Scoparia dulcis L

Chemical and Pharmaceutical Bulletin

Volumn 38, Issue 4, 1990, Pages 945-947

  Hayashi, Toshimitsu ^a   Kawasaki, Masaru ^a   Taga, Tooru ^b   Morita, Naokata ^b   Miwa, Yoshihisa ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

antiviral activity; aphidicolane; diterpenoid; scopadulin; Scoparia dulcis; Scrophulariaceae; X ray analysis

Indexed keywords

SCOPADULIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLOGRAPHY; DRUG STRUCTURE; INFRARED SPECTROPHOTOMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTIVIRAL AGENTS; DITERPENES; MOLECULAR CONFORMATION; PLANTS, MEDICINAL; X-RAY DIFFRACTION;

EID: 0025326776     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.38.945     Document Type: Article

References (7)

1. For paper II, see: T. Hayashi, K. Hayashi, K. Uchida, S. Niwayama and N. Morita, Chem. Pharm. Bull., 38, 239 (1990).
2. T. Hayashi, M. Kishi, M. Kawasaki, M. Arisawa, M. Shimizu, S. Suzuki, M. Yoshizaki, N. Morita, Y. Tezuka, T. Kikuchi, L. H. Berganza, E. Ferro and I. Basualdo, Tetrahedron Lett., 28, 3693 (1987); b) T. Hayashi, M. Kishi, M. Kawasaki, M. Arisawa, N. Morita and L. H. Berganza, J. Nat. Prod., 51, 360 (1988); c) M. Kawasaki, T. Hayashi, M. Arisawa, M. Shimizu, S. Horie, H. Ueno, H. Shogawa, S. Suzuki, M. Yoshizaki, N. Morita, Y. Tezuka, T. Kikuchi, L. H. Berganza, E. Ferro and I. Basualdo, Chem. Pharm. Bull., 35, 3963 (1987); d) M. Kawasaki, T. Hayashi, M. Arisawa, N. Morita and L. H. Berganza, Phytochemistry, 27, 3709 (1988); e) T. Hayashi, K. Uchida, K. Hayashi, S. Niwayama and N. Morita, Chem. Pharm. Bull., 36, 4849 (1988).
3. K. Hayashi, S. Niwayama, T. Hayashi, R. Nago, H. Ochiai and N. Morita, Antiviral Res., 9, 345 (1988).
4. S. Asano, M. Mizutani, T. Hayashi, N. Morita and N. Takeguchi, J. Biol. Chem., submitted.
5. K. M. Brundret, W. Dalziel, B. Hesp, J. A. J. Jarvis and S. Neidle, J. Chem. Soc., Chem. Commun., 1972, 1027; b) W. Dalziel, B. Hesp and K. M. Stevenson, J. Chem. Soc., Perkin Trans. 1, 1973, 2841.
6. Stemodane-type diterpenoids possessing different stereochemistry from that of aphidicolin at C- 9, 13 and 14 were isolated from Scrophulariaceae plant, Stemodia maritima: P. S. Manch, J. D. White, H. Wright and J. Clardy, J. Am. Chem. Soc., 95, 2705 (1973); C. D. Hufford, R. O. Guerrero and N. J. Doorenbos, J. Pharm. Sci., 65. 778 (1976).
7. M. J. Ackland and J. R. Hanson, J. Chem. Soc., Perkin Trans. 1, 1984, 2751.